{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:49:21Z","timestamp":1792500561871,"version":"4.5.0"},"reference-count":48,"publisher":"American Chemical Society (ACS)","issue":"41","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M743167"],"award-info":[{"award-number":["2023M743167"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023TQ0297"],"award-info":[{"award-number":["2023TQ0297"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22301284"],"award-info":[{"award-number":["22301284"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92356304"],"award-info":[{"award-number":["92356304"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92461304"],"award-info":[{"award-number":["92461304"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Henan Province Science and Technology Research and Development Joint Fund","award":["242301420004"],"award-info":[{"award-number":["242301420004"]}]},{"name":"Tianjian Laboratory of Advanced Biomedical Sciences"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Atomically precise metal clusters hold great promise for cancer theranostics, yet current strategies for introducing tumor-targeting functionality often compromise their structural precision. Herein, an erlotinib (Er)-functionalized gold cluster, Au8-Er, is constructed through ligand engineering for targeted non-small-cell lung cancer (NSCLC) theranostics. The Er ligands endow Au8-Er with high affinity toward the epidermal growth factor receptor (EGFR), enabling selective tumor targeting and preferential accumulation at lung tumor sites. Under the glutathione-rich tumor microenvironment, Au8-Er releases Er to achieve chemotherapy. Simultaneously, the cluster exhibits strong X-ray attenuation and oxygen-sensitive phosphorescence, allowing it to function as both an X-ray scintillator and a photosensitizer for efficient X-ray-induced photodynamic therapy (X-PDT) under low-dose irradiation. Moreover, its X-ray-excited luminescence enables high-contrast imaging. The synergistic integration of targeted chemotherapy, X-PDT, and imaging within a structurally precise nanoplatform results in enhanced therapeutic efficacy against NSCLC. This work highlights ligand engineering as an effective strategy for imparting biological functionality to atomically precise metal clusters and advances their application in precision cancer theranostics.<\/jats:p>","DOI":"10.1021\/acsnano.6c15906","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:01:36Z","timestamp":1791259296000},"page":"28008-28018","source":"Crossref","is-referenced-by-count":0,"title":["Erlotinib Engineering\nPrograms Tumor Targeting in\nan Atomically Precise Au8 Cluster"],"prefix":"10.1021","volume":"20","author":[{"given":"Shuai-Bo","family":"Wang","sequence":"first","affiliation":[{"name":"Zhengzhou University , , ,","place":["Zhengzhou, China, 450001"]},{"name":"Zhengzhou University , , ,","place":["Zhengzhou, China, 450001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Yu","family":"Ge","sequence":"additional","affiliation":[{"name":"Zhengzhou University , , ,","place":["Zhengzhou, China, 450001"]},{"name":"Zhengzhou University , , ,","place":["Zhengzhou, China, 450001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Hao","family":"Xu","sequence":"additional","affiliation":[{"name":"Zhengzhou University , , ,","place":["Zhengzhou, China, 450001"]},{"name":"Zhengzhou University , , ,","place":["Zhengzhou, China, 450001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3353-5135","authenticated-orcid":true,"given":"Xueli","family":"Zhao","sequence":"additional","affiliation":[{"name":"Zhengzhou University , , ,","place":["Zhengzhou, China, 450001"]},{"name":"Zhengzhou University , , ,","place":["Zhengzhou, China, 450001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjuan","family":"Sang","sequence":"additional","affiliation":[{"name":"Zhengzhou University , , ,","place":["Zhengzhou, China, 450001"]},{"name":"Zhengzhou University , , ,","place":["Zhengzhou, China, 450001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4423-9844","authenticated-orcid":true,"given":"Zhao-Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhengzhou University , , ,","place":["Zhengzhou, China, 450001"]},{"name":"Zhengzhou University , , ,","place":["Zhengzhou, China, 450001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6728-0559","authenticated-orcid":true,"given":"Shuang-Quan","family":"Zang","sequence":"additional","affiliation":[{"name":"Zhengzhou University , , ,","place":["Zhengzhou, China, 450001"]},{"name":"Zhengzhou University , , ,","place":["Zhengzhou, China, 450001"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"2026102008162612300_cit1","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1021\/acs.accounts.5c00838","article-title":"Toward Multifunctional Metal Nanoclusters with NIR-II\nPhotoluminescence","volume":"59","author":"Gu","year":"2026","journal-title":"Acc. Chem. Res."},{"key":"2026102008162612300_cit2","doi-asserted-by":"publisher","first-page":"9092","DOI":"10.1039\/D5CS00383K","article-title":"Atom-Precise Coinage\nMetal Nanoclusters for Near-Infrared Emission: Excited-State Dynamics\nand Mechanisms","volume":"54","author":"Liu","year":"2025","journal-title":"Chem. Soc. Rev."},{"key":"2026102008162612300_cit3","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202521627","article-title":"Maximized\nFull-Color Circularly Polarized Luminescence from Metal Clusters","volume":"38","author":"Zhang","year":"2026","journal-title":"Adv. Mater."},{"key":"2026102008162612300_cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2025.111155","article-title":"Assessing the Photoluminescence of Metal Nanoclusters: The individual\nVersus the Collective","volume":"37","author":"Du","year":"2026","journal-title":"Chin. Chem. Lett."},{"key":"2026102008162612300_cit5","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1021\/acs.accounts.6c00147","article-title":"Distinct Contributions\nof the Surface\/Interface\/Core\nof Metal Clusters to Catalytic Properties","volume":"59","author":"Liu","year":"2026","journal-title":"Acc.\nChem. Res."},{"key":"2026102008162612300_cit6","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1021\/acs.accounts.5c00897","article-title":"Organometallic Clusters in Catalysis: From Designed\nSynthesis and Structural Evolution to Functional Applications","volume":"59","author":"Zhou","year":"2026","journal-title":"Acc. Chem. Res."},{"key":"2026102008162612300_cit7","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.679","article-title":"Atomically Precise\nCu32 Nanoclusters with Selenide Doping: Synthesis, Bonding,\nand Catalysis","volume":"6","author":"Huo","year":"2025","journal-title":"Aggregate"},{"key":"2026102008162612300_cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2025.111256","article-title":"Dye-Stabilized Atomically\nPrecise Copper Clusters for Enhanced Photocatalytic Hydrogen Evolution","volume":"36","author":"Li","year":"2025","journal-title":"Chin. Chem. Lett."},{"key":"2026102008162612300_cit9","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1021\/acs.accounts.5c00837","article-title":"Atomically\nPrecise\nMetal Clusters for NIR-II Imaging","volume":"59","author":"Ma","year":"2026","journal-title":"Acc. Chem.\nRes."},{"key":"2026102008162612300_cit10","doi-asserted-by":"publisher","first-page":"5195","DOI":"10.1021\/acs.chemrev.4c00835","article-title":"Molecular Gold Nanoclusters for Advanced NIR-II Bioimaging and Therapy","volume":"125","author":"Baghdasaryan","year":"2025","journal-title":"Chem. Rev."},{"key":"2026102008162612300_cit11","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/s41578-024-00741-7","article-title":"Molecule-Like Synthesis\nof Ligand-Protected Metal Nanoclusters","volume":"10","author":"Yao","year":"2025","journal-title":"Nat.\nRev. Mater."},{"key":"2026102008162612300_cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2024.216341","article-title":"Helical\nSelf-Assemblies of Molecule-Like Coinage Metal Nanoclusters and Their\nEmerging Applications","volume":"525","author":"Barik","year":"2025","journal-title":"Coord. Chem. Rev."},{"key":"2026102008162612300_cit13","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202401002","article-title":"Photoluminescent Characterization\nof Metal Nanoclusters: Basic Parameters,\nMethods, and Applications","volume":"36","author":"Lin","year":"2024","journal-title":"Adv. Mater."},{"key":"2026102008162612300_cit14","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.scib.2024.11.002","article-title":"Single-Atom \u201cSurgery\u201d\non Chiral All-Dialkynyl-Protected Superatomic Silver Nanoclusters","volume":"70","author":"Zhang","year":"2025","journal-title":"Sci. Bull."},{"key":"2026102008162612300_cit15","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202517021","article-title":"Highly\nActive Cu14 Cluster Precisely Activates Autophagy Inhibitor\nto Amplify Cuproptosis Immunotherapy","volume":"13","author":"Zang","year":"2026","journal-title":"Adv. Sci."},{"key":"2026102008162612300_cit16","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202519438","article-title":"Atomically\nPrecise Clusterzymes: A Programmable Optoelectronic\nPlatform for Neuroscience","volume":"13","author":"Sun","year":"2026","journal-title":"Adv. Sci."},{"key":"2026102008162612300_cit17","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202507924","article-title":"Metal Nanoclusters\nfor Cancer Imaging and Treatment","volume":"36","author":"Zhu","year":"2026","journal-title":"Adv. Funct.\nMater."},{"key":"2026102008162612300_cit18","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202528658","article-title":"Gold Nanoclusters\nas Dual Agents for Engineering Tumor Vascular Leakiness and Performing\nPhotothermal Therapy","volume":"36","author":"Ni","year":"2026","journal-title":"Adv. Funct. Mater."},{"key":"2026102008162612300_cit19","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202504524","article-title":"Au6Cu2 Clusters with High Electron Affinity and Oxygen-Mimetic\nProperties for Hypoxic Tumor Radiosensitization","volume":"64","author":"Zhao","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026102008162612300_cit20","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.70317","article-title":"Cell Membrane-Camouflaged\nGold Nanoclusters\/Nanoflowers for Synergistic Ferroptosis-Like and\nPhotothermal Therapy of Breast Cancer","volume":"7","author":"Wang","year":"2026","journal-title":"Aggregate"},{"key":"2026102008162612300_cit21","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1038\/nnano.2017.170","article-title":"Glomerular\nBarrier Behaves As an Atomically Precise\nBandpass Filter in a Sub-Nanometre Regime","volume":"12","author":"Du","year":"2017","journal-title":"Nat.\nNanotechnol."},{"key":"2026102008162612300_cit22","doi-asserted-by":"publisher","first-page":"6214","DOI":"10.1002\/anie.201813576","article-title":"A Simple Approach to Design Proteins\nfor the Sustainable Synthesis of Metal Nanoclusters","volume":"58","author":"Aires","year":"2019","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026102008162612300_cit23","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1002\/anie.202010870","article-title":"A New Class\nof NIR-II Gold Nanocluster-Based Protein Biolabels for in Vivo Tumor-Targeted\nImaging","volume":"60","author":"Song","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026102008162612300_cit24","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.70046","article-title":"Construction of\nActive Sites-Accessible Au8 Clusters for Intensive Tumor\nPyroptosis","volume":"6","author":"Zang","year":"2025","journal-title":"Aggregate"},{"key":"2026102008162612300_cit25","doi-asserted-by":"publisher","first-page":"6542","DOI":"10.1039\/D4SC08599J","article-title":"Glutathione: a Naturally\nOccurring Tripeptide for Functional Metal Nanomaterials","volume":"16","author":"Yang","year":"2025","journal-title":"Chem. Sci."},{"key":"2026102008162612300_cit26","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202203734","article-title":"Composition-Dependent\nEnzyme Mimicking Activity and Radiosensitizing Effect of Bimetallic\nClusters to Modulate Tumor Hypoxia for Enhanced Cancer Therapy","volume":"34","author":"Hua","year":"2022","journal-title":"Adv. Mater."},{"key":"2026102008162612300_cit27","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1021\/acsnano.5c12046","article-title":"Precision-Architected Drug-Stabilized\nCu5 Clusters Mediate Multimodal Therapeutic Intervention\nin Colitis","volume":"20","author":"Sang","year":"2026","journal-title":"ACS Nano"},{"key":"2026102008162612300_cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2023.215360","article-title":"New Insights on Transition Metal Coordination Compounds\nwith Biological Active Azole and Nitroimidazole Derivatives","volume":"494","author":"Navarro-Pen\u0303aloza","year":"2023","journal-title":"Coord. Chem. Rev."},{"key":"2026102008162612300_cit29","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.70269","article-title":"Peptide and\nDrug-Protected\nGold Nanoclusters As Promising Biomaterials: Synthesis, Properties,\nand Applications","volume":"7","author":"Moura","year":"2026","journal-title":"Aggregate"},{"key":"2026102008162612300_cit30","doi-asserted-by":"publisher","first-page":"595","DOI":"10.2174\/0929867330666230309143711","article-title":"A. Structure-based\nVirtual Screening, Molecular Docking,\nMolecular Dynamics Simulation, and Metabolic Reactivity Studies of\nQuinazoline Derivatives for their Anti-EGFR Activity Against Tumor\nAngiogenesis","volume":"31","author":"Shah","year":"2024","journal-title":"Curr. Med. Chem."},{"key":"2026102008162612300_cit31","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1186\/s12951-025-03256-7","article-title":"Atomically-Precise\nAu22(Lys-Cys-Lys)16 Nanoclusters\nfor Radiation Sensitization","volume":"23","author":"Zeinizade","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"2026102008162612300_cit32","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202507412","article-title":"Hydrogen-Bonding-Assisted\nAssembly\nof Stable High-Nuclearity Copper(I)-Alkyne Nanoclusters for X-Ray\nScintillation","volume":"64","author":"Han","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026102008162612300_cit33","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202417001","article-title":"Hydrogen-Bonded Organic\nFramework Nanoscintillators for X-Ray-Induced Photodynamic Therapy\nin Hepatocellular Carcinoma","volume":"37","author":"Gu","year":"2025","journal-title":"Adv. Mater."},{"key":"2026102008162612300_cit34","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adq5331","article-title":"Targeted Suppression\nof Glioma by Ultralow-Dose X-Ray-Induced Photodynamic Therapy and\nGold-Based Nanoclusters in Preclinical Models","volume":"17","author":"Li","year":"2025","journal-title":"Sci. Transl. Med."},{"key":"2026102008162612300_cit35","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1038\/s41565-024-01809-9","article-title":"A Cascade\nX-Ray Energy\nConverting Approach Toward Radio-Afterglow Cancer Theranostics","volume":"20","author":"Xu","year":"2025","journal-title":"Nat. Nanotechnol."},{"key":"2026102008162612300_cit36","doi-asserted-by":"publisher","first-page":"5091","DOI":"10.1038\/s41467-022-32054-0","article-title":"Organic Phosphorescent Nanoscintillator\nfor Low-Dose X-Ray-Induced Photodynamic Therapy","volume":"13","author":"Wang","year":"2022","journal-title":"Nat. Commun."},{"key":"2026102008162612300_cit37","doi-asserted-by":"publisher","first-page":"9914","DOI":"10.1002\/anie.201908712","article-title":"Aggregation-Induced\nEmission Gold\nClustoluminogens for Enhanced Low-Dose X-ray-Induced Photodynamic\nTherapy","volume":"59","author":"Sun","year":"2020","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026102008162612300_cit38","doi-asserted-by":"publisher","first-page":"7442","DOI":"10.1002\/anie.201102901","article-title":"Generation\nof Small Gold Clusters\nwith Unique Geometries Through Cluster-to-Cluster Transformations:\nOctanuclear Clusters with Edge-Sharing Gold Tetrahedron Motifs","volume":"50","author":"Kamei","year":"2011","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026102008162612300_cit39","doi-asserted-by":"publisher","first-page":"2443","DOI":"10.1002\/anie.201814359","article-title":"Unusual Attractive Au\u2212\u03c0\nInteractions in Small Diacetylene-Modified Gold Clusters","volume":"58","author":"Iwasaki","year":"2019","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026102008162612300_cit40","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adj9013","article-title":"Halogen\nbonding-driven chiral amplification of a bimetallic gold-copper cluster\nthrough hierarchical assembly","volume":"9","author":"Wang","year":"2023","journal-title":"Sci. Adv."},{"key":"2026102008162612300_cit41","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/j.jconrel.2023.07.006","article-title":"Strategies to Prolong\nDrug Retention in Solid Tumors by Aggregating\nEndo-CMC Nanoparticles","volume":"360","author":"Xia","year":"2023","journal-title":"J. Controlled Release"},{"key":"2026102008162612300_cit42","doi-asserted-by":"publisher","first-page":"18748","DOI":"10.1039\/D5SC04701C","article-title":"Revealing the exchange\nkinetics of thiol-capped Au25 nanoclusters with alkynyl ligands","volume":"16","author":"Chen","year":"2025","journal-title":"Chem. Sci."},{"key":"2026102008162612300_cit43","doi-asserted-by":"publisher","first-page":"6239","DOI":"10.1039\/D0NR00869A","article-title":"Acetylide-for-thiolate and thiolate-for-acetylide\nexchange on gold nanoclusters","volume":"12","author":"Hosier","year":"2020","journal-title":"Nanoscale"},{"key":"2026102008162612300_cit44","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1002\/cjoc.201600481","article-title":"Erlotinib\nAnalogue-Substituted Zinc(II) Phthalocyanines for Small Molecular\nTarget-based Photodynamic Cancer Therapy","volume":"34","author":"Chen","year":"2016","journal-title":"Chin.\nJ. Chem."},{"key":"2026102008162612300_cit45","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1016\/j.ijbiomac.2020.07.048","article-title":"Kinetic and Thermodynamic\nInsights into Interaction of Erlotinib with Epidermal Growth Factor\nReceptor: Surface Plasmon Resonance and Molecular Docking Approaches","volume":"163","author":"Mohammadzadeh-Asl","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"2026102008162612300_cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2026.217883","article-title":"Dual-Activated Photosensitizers for\nPrecision Photodynamic Therapy: Mechanisms and Applications","volume":"560","author":"Xu","year":"2026","journal-title":"Coord. Chem. Rev."},{"key":"2026102008162612300_cit47","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202303091","article-title":"BPTF Drives Gastric Cancer Resistance\nto EGFR Inhibitor\nby Epigenetically Regulating the C-MYC\/PLCG1\/Perk Axis","volume":"10","author":"Li","year":"2023","journal-title":"Adv. Sci."},{"key":"2026102008162612300_cit48","doi-asserted-by":"publisher","first-page":"4019","DOI":"10.1039\/D3SC06222H","article-title":"Molecular Engineering of AIE-Active Boron Clustoluminogens\nfor Enhanced Boron Neutron Capture Therapy","volume":"15","author":"Ma","year":"2024","journal-title":"Chem. Sci."}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.6c15906","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/20\/41\/28008\/68751911\/acsnano.6c15906.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/20\/41\/28008\/68751911\/acsnano.6c15906.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:31:01Z","timestamp":1792499461000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancac3\/article\/20\/41\/28008\/5444920\/Erlotinib-Engineering-Programs-Tumor-Targeting-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,5]]},"references-count":48,"journal-issue":{"issue":"41","published-online":{"date-parts":[[2026,10,5]]},"published-print":{"date-parts":[[2026,10,20]]}},"URL":"https:\/\/doi.org\/10.1021\/acsnano.6c15906","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,5]]}}}