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The engineered nanomaterial, composed of short, single-stranded DNA and a single nanotube chirality, localizes exclusively to the lumen of endolysosomal organelles without adversely affecting cell viability or proliferation or organelle morphology, integrity, or function. The emission wavelength of the reporter can be spatially resolved from within the endolysosomal lumen to generate quantitative maps of lipid content in live cells. Endolysosomal lipid accumulation in cell lines, an example of drug-induced phospholipidosis, was observed for multiple drugs in macrophages, and measurements of patient-derived Niemann\u2013Pick type C fibroblasts identified lipid accumulation and phenotypic reversal of this lysosomal storage disease. Single-cell measurements using the reporter discerned subcellular differences in equilibrium lipid content, illuminating significant intracellular heterogeneity among endolysosomal organelles of differentiating bone-marrow-derived monocytes. Single-cell kinetics of lipoprotein-derived cholesterol accumulation within macrophages revealed rates that differed among cells by an order of magnitude. This carbon nanotube optical reporter of endolysosomal lipid content in live cells confers additional capabilities for drug development processes and the investigation of lipid-linked diseases.<\/jats:p>","DOI":"10.1021\/acsnano.7b04743","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T16:05:45Z","timestamp":1505232345000},"page":"10689-10703","source":"Crossref","is-referenced-by-count":125,"title":["A\nCarbon Nanotube Optical Reporter Maps Endolysosomal\nLipid Flux"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5493-3058","authenticated-orcid":true,"given":"Prakrit V.","family":"Jena","sequence":"first","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center , , ,","place":["New York, New York, United States, 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10065"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeetain","family":"Mittal","sequence":"additional","affiliation":[{"name":"Lehigh University , , , ,","place":["Bethlehem, Pennsylvania, United States, 18015"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick R.","family":"Maxfield","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine , , ,","place":["New York, New York, United States, 10065"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna A.","family":"Joyce","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center , , ,","place":["New York, New York, United States, 10065"]},{"name":"Weill Cornell Medicine , , ,","place":["New York, New York, United States, 10065"]},{"name":"University of Lausanne , , ,","place":["Lausanne, Switzerland, CH 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