{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T18:32:30Z","timestamp":1785263550973,"version":"3.55.0"},"reference-count":73,"publisher":"American Chemical Society (ACS)","issue":"4","license":[{"start":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T00:00:00Z","timestamp":1553558400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T00:00:00Z","timestamp":1553558400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T00:00:00Z","timestamp":1553558400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773649"],"award-info":[{"award-number":["81773649"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004147","name":"Tsinghua University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004147","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA211930"],"award-info":[{"award-number":["R01CA211930"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA192221"],"award-info":[{"award-number":["R01CA192221"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Novagenesis Theraputix Limited"},{"name":"Beijing Advanced Innovation Center for Structural Biologys, Tsinghua University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2019,4,23]]},"DOI":"10.1021\/acsnano.8b08246","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T23:13:08Z","timestamp":1553641988000},"page":"4049-4063","source":"Crossref","is-referenced-by-count":127,"title":["Targeting the Oncogene KRAS Mutant Pancreatic Cancer by Synergistic Blocking of Lysosomal Acidification and Rapid Drug Release"],"prefix":"10.1021","volume":"13","author":[{"given":"Chao","family":"Kong","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, Beijing Advanced Innovation Center for Structural Biology, and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengsheng","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Beijing Advanced Innovation Center for Structural Biology, and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxiao","family":"Ye","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Beijing Advanced Innovation Center for Structural Biology, and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Beijing Advanced Innovation Center for Structural Biology, and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijian","family":"Kong","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Beijing Advanced Innovation Center for Structural Biology, and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqin","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Beijing Advanced Innovation Center for Structural Biology, and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Beijing Advanced Innovation Center for Structural Biology, and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Pang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeping","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0726-5098","authenticated-orcid":true,"given":"Jinming","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7415-6997","authenticated-orcid":true,"given":"Feng","family":"Qian","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Beijing Advanced Innovation Center for Structural Biology, and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2019,3,26]]},"reference":[{"key":"ref1\/cit1","unstructured":"Steward, B.; Wild, C.; Stewart, B.; Wild, C. World Cancer Report 2014 International Agency for Research on Cancer World Health Organization; International Agency for Research on Cancer, World Health Organization 2014."},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.275776.115"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1404198"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/nature11547"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam7622"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2013.12.004"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-016-1382-7"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2013.04.004"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0005-x"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-2318"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.2174\/09298673113209990238"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.182"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-2211"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.06.017"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/nature12138"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/nature14587"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00261"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-2425"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.12.006"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.12.039"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-111315-125125"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3565"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","DOI":"10.1002\/9781118978320","volume-title":"Lysosomes: Biology, Diseases, and Therapeutics","author":"Maxfield F. R.","year":"2016"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201603794"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1126\/science.1193497"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1738"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan6298"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-15-0671"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.71"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjt022"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9524"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040531"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.522"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13214"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201606121"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.09.013"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.09.026"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.5b00448"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/ar300031y"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201201390"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.01.065"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201100884"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1039\/C6PY01104G"},{"key":"ref44\/cit44","doi-asserted-by":"crossref","DOI":"10.1002\/9781118573983.ch4","volume-title":"Molecular Modeling of Block Copolymer Self-Assembly and Micellar Drug Delivery","author":"Kang M.","year":"2015"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2820"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-012110-142317"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2014.00306"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2014.004"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-9335(98)80061-7"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1038\/nri3607"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1972.33"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/nature12040"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms16031"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29501"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1021\/nn203503h"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e31824abdc0"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2012.01.006"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15130"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3972"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004334"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4389"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2007.12.017"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2013.11.009"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.01.061"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.04.023"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.021055"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2015.04.003"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1007\/BF03218464"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9797(02)00082-6"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(01)00030-8"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-16-0125"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15983"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.8b08246","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T12:34:33Z","timestamp":1682426073000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.8b08246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,26]]},"references-count":73,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4,23]]}},"alternative-id":["10.1021\/acsnano.8b08246"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.8b08246","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,26]]}}}