{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:19:14Z","timestamp":1792790354254,"version":"4.5.0"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"Steven and Alexandra Cohen Foundation","id":[{"id":"https:\/\/ror.org\/04ns7ha44","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2020,1,28]]},"DOI":"10.1021\/acsnano.9b08151","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T08:04:12Z","timestamp":1576656252000},"page":"229-240","source":"Crossref","is-referenced-by-count":119,"title":["Point-of-Care Serodiagnostic Test for Early-Stage Lyme Disease Using a Multiplexed Paper-Based Immunoassay and Machine Learning"],"prefix":"10.1021","volume":"14","author":[{"given":"Hyou-Arm","family":"Joung","sequence":"first","affiliation":[{"name":"Department of Electrical & Computer Engineering, University of California, Los Angeles, California 90025, United States"},{"name":"California NanoSystems Institute (CNSI), University of California, Los Angeles, California 90025, United States"},{"name":"Department of Bioengineering, University of California, Los Angeles, California 90025, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2831-1930","authenticated-orcid":true,"given":"Zachary S.","family":"Ballard","sequence":"additional","affiliation":[{"name":"Department of Electrical & Computer Engineering, University of California, Los Angeles, California 90025, United States"},{"name":"California NanoSystems Institute (CNSI), University of California, Los Angeles, California 90025, United States"},{"name":"Department of Bioengineering, University of California, Los Angeles, California 90025, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Electrical & Computer Engineering, University of California, Los Angeles, California 90025, United States"},{"name":"Department of Chemistry, Lanzhou University, Lanzhou, Gansu 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek K.","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Electrical & Computer Engineering, University of California, Los Angeles, California 90025, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailemariam","family":"Teshome","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of California, Los Angeles, California 90025, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linghao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, University of California, Los Angeles, California 90025, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Horn","sequence":"additional","affiliation":[{"name":"Lyme Disease Biobank, Portland, Oregon 97221, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Arnaboldi","sequence":"additional","affiliation":[{"name":"Department of Microbiology\/Immunology, New York Medical College, Valhalla, New York 10595, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond J.","family":"Dattwyler","sequence":"additional","affiliation":[{"name":"Department of Microbiology\/Immunology, New York Medical College, Valhalla, New York 10595, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omai B.","family":"Garner","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of California, Los Angeles, California 90025, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3942-4284","authenticated-orcid":true,"given":"Dino","family":"Di Carlo","sequence":"additional","affiliation":[{"name":"California NanoSystems Institute (CNSI), University of California, Los Angeles, California 90025, United States"},{"name":"Department of Bioengineering, University of California, Los Angeles, California 90025, United States"},{"name":"Department of Mechanical Engineering, University of California, Los Angeles, California 90025, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0717-683X","authenticated-orcid":true,"given":"Aydogan","family":"Ozcan","sequence":"additional","affiliation":[{"name":"Department of Electrical & Computer Engineering, University of California, Los Angeles, California 90025, United States"},{"name":"California NanoSystems Institute (CNSI), University of California, Los Angeles, California 90025, United States"},{"name":"Department of Bioengineering, University of California, Los Angeles, California 90025, United States"},{"name":"Department of Surgery, University of California, Los Angeles, California 90025, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2019,12,18]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2109.150417"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60103-7"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1086\/508667"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200306123482423"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp061181"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1314325"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.medici.2015.12.001"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3201\/2207.151694"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy614"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2018.01.030"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/167.2.392"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01853-13"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.03394-15"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1086\/313688"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6832a4"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00749-18"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2015.02.005"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-1468-4"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00189-06"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1128\/JCM.38.5.1735-1739.2000","volume":"38","author":"Magnarelli L. A.","year":"2000","journal-title":"J. Clin. Microbiol."},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.05095-0"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1128\/jcm.33.2.419-427.1995","volume":"33","author":"Engstrom S. M.","year":"1995","journal-title":"J. Clin. Microbiol."},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu397"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.16.2015"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1039\/C6LC00737F"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1039\/C8RA06132G"},{"key":"ref27\/cit27","unstructured":"Quidel Receives FDA Clearance, CLIA Waiver for Its Point-of-Care\nSofia\u00ae 2 Lyme Fluorescent Immunoassay for Use with Sofia\u00ae\n2 Instrument from Finger-Stick Whole Blood Specimens http:\/\/ir.quidel.com\/news-releases\/news-release-details\/quidel-receives-fda-clearance-clia-waiver-its-point-care-sofiar (accessed Sep 3, 2019)."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"3990","DOI":"10.1128\/JCM.37.12.3990-3996.1999","volume":"37","author":"Liang F. T.","year":"1999","journal-title":"J. Clin. Microbiol."},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00217-15"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piy133"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02111-15"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00048-08"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00409-10"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.14585"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0316-z"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0000000000000687"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix943"},{"key":"ref38\/cit38","first-page":"693","volume":"56","author":"Bouchard C.","year":"2015","journal-title":"Can. Vet J."},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ttbdis.2014.09.006"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.3201\/eid2108.141878"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1038\/srep35069"},{"key":"ref42\/cit42","unstructured":"Sofia Lyme FIA | Quidel https:\/\/www.quidel.com\/immunoassays\/rapid-lyme-tests\/sofia-lyme-fia (accessed Sep 13, 2019)."},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01142-19"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1039\/C9LC00011A"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu703"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03749.x"},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1128\/JCM.38.7.2530-2535.2000","volume":"38","author":"Gomes-Solecki M. J. C.","year":"2000","journal-title":"J. Clin. Microbiol."},{"key":"ref48\/cit48","first-page":"297","volume":"72","author":"DePietropaolo D. L.","year":"2005","journal-title":"Am. Fam. Physician."},{"key":"ref49\/cit49","first-page":"667436","author":"Ballard Z.","year":"2019","journal-title":"bioRxiv"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.9b08151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T14:44:15Z","timestamp":1681483455000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.9b08151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,18]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1,28]]}},"alternative-id":["10.1021\/acsnano.9b08151"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.9b08151","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/19009423","asserted-by":"object"}]},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,18]]}}}