{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:12:41Z","timestamp":1788318761272,"version":"build-2803163510"},"reference-count":47,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T00:00:00Z","timestamp":1583280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_ccby_termsofuse.html"}],"funder":[{"DOI":"10.13039\/501100005881","name":"Emberi Eroforr\u00c3\u00a1sok Miniszt\u00c3\u00a9riuma","doi-asserted-by":"publisher","award":["T\u00c3&#x81;MOP-4.2.2.B-10\/1-2010-0009"],"award-info":[{"award-number":["T\u00c3&#x81;MOP-4.2.2.B-10\/1-2010-0009"]}],"id":[{"id":"10.13039\/501100005881","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A previously developed and industrially feasible process for selective, Pd-mediated, liquid-phase heterogeneous catalytic hydrogenation of nitriles to primary amines was extended to the reduction of 3-phenylpropionitrile (PPN) to 3-phenylpropylamine (PPA). PPN, which belongs to the homologous series of benzonitrile (BN) and benzyl cyanide (BC), was hydrogenated under mild reaction conditions (30\u201380 \u00b0C, 6 bar), over Pd\/C, in two immiscible solvents (dichloromethane\/water) and using acidic additives (NaH2PO4 and H2SO4). Although relatively high conversion (76%) was achieved, the selectivity to PPA (26%) and its isolated yield (20%) were lesser than those in the case of the hydrogenation of BN or BC reported earlier. However, the purity of PPA was &amp;gt;99% without using any purification method. Quantum chemical calculations using a density functional theory (DFT) method were performed to compare the adsorption interactions of the different imine intermediates on palladium, as well as to clarify the differences observed in the primary amine selectivity. PPA is a valuable intermediate for the synthesis of carboxypeptidase B enzyme inhibitors, antimuscarinic drugs, or potential anticancer agents in the pharmaceutical industry.<\/jats:p>","DOI":"10.1021\/acsomega.0c00125","type":"journal-article","created":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T09:53:50Z","timestamp":1583315630000},"page":"5487-5497","source":"Crossref","is-referenced-by-count":12,"title":["Heterogeneous Catalytic Hydrogenation of 3-Phenylpropionitrile\nover Palladium on Carbon"],"prefix":"10.1021","volume":"5","author":[{"given":"Krisztina","family":"Le\u0301vay","sequence":"first","affiliation":[{"name":"Budapest University of Technology and Economics , , Budafoki u\u0301t 8 , ,","place":["Budapest, Hungary, H-1111"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamilla Do\u0301ra","family":"To\u0301th","sequence":"additional","affiliation":[{"name":"Budapest University of Technology and Economics , , Budafoki u\u0301t 8 , ,","place":["Budapest, Hungary, H-1111"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tama\u0301s","family":"Ka\u0301rpa\u0301ti","sequence":"additional","affiliation":[{"name":"Budapest University of Technology and Economics , , Budafoki u\u0301t 8 , ,","place":["Budapest, Hungary, H-1111"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7980-0443","authenticated-orcid":true,"given":"La\u0301szlo\u0301","family":"Hegedu\u030bs","sequence":"additional","affiliation":[{"name":"Budapest University of Technology and Economics , , Budafoki u\u0301t 8 , ,","place":["Budapest, Hungary, H-1111"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,3,4]]},"reference":[{"key":"2026090122183452300_cit1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.apcata.2005.08.024","article-title":"Selective\nheterogeneous catalytic hydrogenation of\nnitriles to primary amines in liquid phase Part I. Hydrogenation of\nbenzonitrile over palladium","volume":"296","author":"Hegedu\u030bs","year":"2005","journal-title":"Appl. Catal., A"},{"key":"2026090122183452300_cit2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.apcata.2008.07.012","article-title":"Selective heterogeneous\ncatalytic hydrogenation of nitriles to primary amines in liquid phase\nPart II. Hydrogenation of benzyl cyanide over palladium","volume":"349","author":"Hegedu\u030bs","year":"2008","journal-title":"Appl. Catal., A"},{"key":"2026090122183452300_cit3","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1016\/j.matlet.2006.07.109","article-title":"A one-step hydrothermal way for the\nsynthesis of vanadium oxide nanotubes containing the phenylpropylamine\nas template obtained via non-alkoxide route","volume":"61","author":"Sediri","year":"2007","journal-title":"Mater. 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Matter"},{"key":"2026090122183452300_cit47","doi-asserted-by":"publisher","first-page":"3865","DOI":"10.1103\/physrevlett.77.3865","article-title":"Generalized\nGradient Approximation\nMade Simple","volume":"77","author":"Perdew","year":"1996","journal-title":"Phys. Rev. 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