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New products must be safe and ecofriendly in accordance with the actual legislation. In this context, we present a quantitative structure\u2013activity relationship strategy based on molecular topology as a tool for generating natural products as potential fungicides following a mechanism of action based on the synthesis of chitin inhibition (chitinase inhibition). Two discriminant equations using statistical linear discriminant analysis were used to identify three potential candidates (1-methylxanthine, hematommic acid, and antheraxanthin). The equations showed accuracy and specificity levels above 80%, minimizing the risk of selecting false active compounds.<\/jats:p>","DOI":"10.1021\/acsomega.0c00177","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T03:48:48Z","timestamp":1593229728000},"page":"16358-16365","source":"Crossref","is-referenced-by-count":10,"title":["Molecular Topology QSAR Strategy for Crop Protection:\nNew Natural Fungicides with Chitin Inhibitory Activity"],"prefix":"10.1021","volume":"5","author":[{"given":"Maria","family":"Galvez-Llompart","sequence":"first","affiliation":[{"name":"Universidad Politecnica de Valencia , , Avenida de los Naranjos s\/n , ,","place":["Valencia, Spain, E-46022"]},{"name":"University of Valencia , , ,","place":["Valencia, Spain, 46010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Zanni","sequence":"additional","affiliation":[{"name":"Universidad de Malaga , , Bulevar Louis Pasteur 31 , ,","place":["Malaga, Spain, 29071"]},{"name":"University of Valencia , , ,","place":["Valencia, Spain, 46010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Galvez","sequence":"additional","affiliation":[{"name":"University of Valencia , , ,","place":["Valencia, Spain, 46010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1137-0587","authenticated-orcid":true,"given":"Ramon","family":"Garcia-Domenech","sequence":"additional","affiliation":[{"name":"University of Valencia , , ,","place":["Valencia, Spain, 46010"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,6,26]]},"reference":[{"key":"2026090212445915300_cit1","doi-asserted-by":"publisher","first-page":"214","DOI":"10.3389\/fmicb.2019.00214","article-title":"The Still Underestimated Problem\nof Fungal Diseases Worldwide","volume":"10","author":"Almeida","year":"2019","journal-title":"Front. 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