{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:18:43Z","timestamp":1788355123582,"version":"build-2803163510"},"reference-count":47,"publisher":"American Chemical Society (ACS)","issue":"17","license":[{"start":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/na","name":"Oman Research Council","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We report five new transition-metal complexes that inhibit the urease enzyme. Barbituric acid (BTA), thiobarbituric acid (TBA), isoniazid (INZ), and nicotinamide (NCA) ligands were employed in complexation reactions. The resulting complexes were characterized using a variety of analytical techniques including infra-red and UV\u2013vis spectroscopy, 1H NMR spectroscopy, elemental analysis, and single-crystal X-ray diffraction analysis. We describe two mononuclear complexes with a general formula {[M(NCA)2(H2O)4](BTA)2(H2O)}, where M = Co (1) and Zn (2), a mononuclear complex {[Ni(NCA)2(H2O)4](TBA)2(H2O)} (3), and two polymeric chains of a general formula {[M(INZ) (H2O)3](BTA)2(H2O)3}, where M = Co (4) and Zn (5). These complexes displayed significant urease enzyme inhibition with IC50 values in the range of 3.9\u201319.9 \u03bcM.<\/jats:p>","DOI":"10.1021\/acsomega.0c01089","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T12:48:44Z","timestamp":1587386924000},"page":"10200-10206","source":"Crossref","is-referenced-by-count":17,"title":["Complexes of N- and O-Donor Ligands as Potential\nUrease Inhibitors"],"prefix":"10.1021","volume":"5","author":[{"given":"Syed Raza","family":"Shah","sequence":"first","affiliation":[{"name":"University of Nizwa , , Birkat Almouz, ,","place":["Nizwa, Oman, 616"]},{"name":"Bacha Khan University Charsadda , , ,","place":["Charsadda, Khyber Pakhtunkhwa, Pakistan, 24420"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4805-3091","authenticated-orcid":true,"given":"Zarbad","family":"Shah","sequence":"additional","affiliation":[{"name":"Bacha Khan University Charsadda , , ,","place":["Charsadda, Khyber Pakhtunkhwa, Pakistan, 24420"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Khiat","sequence":"additional","affiliation":[{"name":"University of Nizwa , , Birkat Almouz, ,","place":["Nizwa, Oman, 616"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajmal","family":"Khan","sequence":"additional","affiliation":[{"name":"University of Nizwa , , Birkat Almouz, ,","place":["Nizwa, Oman, 616"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5960-3664","authenticated-orcid":true,"given":"Leila R.","family":"Hill","sequence":"additional","affiliation":[{"name":"University of Oxford , , 12 Mansfield Road , ,","place":["Oxford, U.K., OX1 3TA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakeel","family":"Khan","sequence":"additional","affiliation":[{"name":"Bacha Khan University Charsadda , , ,","place":["Charsadda, Khyber Pakhtunkhwa, Pakistan, 24420"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javid","family":"Hussain","sequence":"additional","affiliation":[{"name":"University of Nizwa , , Birkat Almouz, ,","place":["Nizwa, Oman, 616"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene\u0301","family":"Csuk","sequence":"additional","affiliation":[{"name":"Martin-Luther-University Halle-Wittenberg , , Kurt-Mothes-Str. 2 , ,","place":["Halle (Saale), Germany, d-06120"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4740-5737","authenticated-orcid":true,"given":"Muhammad U.","family":"Anwar","sequence":"additional","affiliation":[{"name":"University of Nizwa , , Birkat Almouz, ,","place":["Nizwa, Oman, 616"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Al-Harrasi","sequence":"additional","affiliation":[{"name":"University of Nizwa , , Birkat Almouz, ,","place":["Nizwa, Oman, 616"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,4,20]]},"reference":[{"key":"2026090208354280200_cit1","doi-asserted-by":"publisher","first-page":"2334","DOI":"10.1039\/b807219c","article-title":"Polytopic\nLigand Directed Self-Assembly\u2500Polymetallic\n[N\u00d7N] Grids versus Non-Grid Oligomers","volume":"38","author":"Dawe","year":"2009","journal-title":"Chem. 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