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Calculations have been carried out at the M05(SMD)\/6-311+G(d,p) level of theory using water as the solvent. The results obtained indicate that AG is capable of forming a wide array of stable coordination compounds with Cu(II) under physiological pH conditions, and it possesses some degree of secondary antioxidant activity when coordinating to copper. The most thermodynamically stable complex can slow down 2.8 times the first step of the Haber\u2013Weiss cycle (from 7.71 \u00d7 109 to 2.80 \u00d7 109 M\u20131 s\u20131) and slightly reduce the potential damage that the formation of \u2022OH radicals can cause. The results of this research add to previous knowledge on this molecule, which could be used as a potential glycation inhibitor.<\/jats:p>","DOI":"10.1021\/acsomega.0c01175","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T06:31:20Z","timestamp":1591857080000},"page":"14502-14512","source":"Crossref","is-referenced-by-count":18,"title":["Theoretical Study of the Copper Complexes with Aminoguanidine:\nInvestigating Secondary Antioxidant Activity"],"prefix":"10.1021","volume":"5","author":[{"given":"Guillermo","family":"Garci\u0301a-Di\u0301ez","sequence":"first","affiliation":[{"name":"Thompson Rivers University , , , ,","place":["Kamloops, British Columbia, Canada, V2C 0C8"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Ramis","sequence":"additional","affiliation":[{"name":"Universitat de les Illes Balears , , ,","place":["Palma de Mallorca, Spain, 07122"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1648-2222","authenticated-orcid":true,"given":"Nelaine","family":"Mora-Diez","sequence":"additional","affiliation":[{"name":"Thompson Rivers University , , , ,","place":["Kamloops, British Columbia, Canada, V2C 0C8"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,6,11]]},"reference":[{"key":"2026090207314459200_cit1","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s00726-003-0017-9","article-title":"Maillard reaction\nproducts in tissue proteins: new\nproducts and new perspectives","volume":"25","author":"Thorpe","year":"2003","journal-title":"Amino Acids"},{"key":"2026090207314459200_cit2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1210\/rp.56.1.1","article-title":"Protein glycation,\ndiabetes, and aging","volume":"56","author":"Ulrich","year":"2001","journal-title":"Recent Prog. 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