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Our study yielded five drugs that successfully inhibited B. cereus growth: dichlorophen, oxiconazole, suloctidil, bithionol, and hexestrol. These drugs exhibited varying levels of efficacy in broad-spectrum experiments against several Gram-positive and Gram-negative bacterial strains, with hexestrol showing the greatest inhibition across all tested strains. Through tests for the efficacy of each drug on B. cereus, bithionol was the single most potent compound on both solid and liquid media and exhibited even greater eradication of B. cereus in combination with suloctidil on solid agar. This multifaceted in vitro study of approved drugs demonstrates the potential to repurpose these drugs as treatments for anthrax disease in a time-efficient manner to address a global health need.<\/jats:p>","DOI":"10.1021\/acsomega.0c03207","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T07:23:36Z","timestamp":1597735416000},"page":"21929-21939","source":"Crossref","is-referenced-by-count":10,"title":["Repurposing Clinically Approved Drugs\nfor the Treatment of\n                    <i>Bacillus cereus<\/i>\n                    , a Surrogate for\n                    <i>Bacillus anthracis<\/i>"],"prefix":"10.1021","volume":"5","author":[{"given":"Masami","family":"Amakawa","sequence":"first","affiliation":[{"name":"Keck Graduate Institute , , , ,","place":["Claremont, California, United States, 91711"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soneli","family":"Gunawardana","sequence":"additional","affiliation":[{"name":"Keck Graduate Institute , , , ,","place":["Claremont, California, United States, 91711"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexy","family":"Jabbour","sequence":"additional","affiliation":[{"name":"Keck Graduate Institute , , , ,","place":["Claremont, California, United States, 91711"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Keck Graduate Institute , , , ,","place":["Claremont, California, United States, 91711"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chase","family":"Pasos","sequence":"additional","affiliation":[{"name":"Keck Graduate Institute , , , ,","place":["Claremont, California, United States, 91711"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleem","family":"Alameh","sequence":"additional","affiliation":[{"name":"Keck Graduate Institute , , , ,","place":["Claremont, California, United States, 91711"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2577-2915","authenticated-orcid":true,"given":"Mikhail","family":"Martchenko Shilman","sequence":"additional","affiliation":[{"name":"Keck Graduate Institute , , , ,","place":["Claremont, California, United States, 91711"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2485-4097","authenticated-orcid":true,"given":"Anastasia","family":"Levitin","sequence":"additional","affiliation":[{"name":"Keck Graduate Institute , , , ,","place":["Claremont, California, United States, 91711"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,8,18]]},"reference":[{"key":"2026092106174172800_cit1","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1128\/CMR.00073-09","article-title":"Bacillus cereus, a Volatile Human Pathogen","volume":"23","author":"Bottone","year":"2010","journal-title":"Clin. 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