{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:13:04Z","timestamp":1788361984155,"version":"build-2803163510"},"reference-count":30,"publisher":"American Chemical Society (ACS)","issue":"37","license":[{"start":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T00:00:00Z","timestamp":1599782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20K05192"],"award-info":[{"award-number":["JP20K05192"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009023","name":"Precursory Research for Embryonic Science and Technology","doi-asserted-by":"publisher","award":["8005"],"award-info":[{"award-number":["8005"]}],"id":[{"id":"10.13039\/501100009023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009037","name":"Science and Technology Research Partnership for Sustainable Development","doi-asserted-by":"publisher","award":["JPMJSA1505"],"award-info":[{"award-number":["JPMJSA1505"]}],"id":[{"id":"10.13039\/501100009037","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Extraction of lutein from raw macroalgae Monostroma nitidum was conducted using a simple method employing dimethyl ether (DME) as a solvent. DME extraction enabled omission of conventional drying and cell wall disruption steps, yielding 0.30 mg\/g dry lutein from wet M. nitidum. The yield of extracted lutein was higher than that by chloroform\u2013methanol extraction from freeze-dried and cell-disrupted M. nitidum. DME extraction provides a safe, eco-friendly approach that combines high yields of lutein with unheated drying of wet macroalgae in a single step.<\/jats:p>","DOI":"10.1021\/acsomega.0c03358","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T08:41:20Z","timestamp":1599813680000},"page":"24005-24010","source":"Crossref","is-referenced-by-count":32,"title":["Direct Extraction of Lutein from Wet\nMacroalgae by Liquefied Dimethyl Ether without Any Pretreatment"],"prefix":"10.1021","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8393-4276","authenticated-orcid":true,"given":"Hideki","family":"Kanda","sequence":"first","affiliation":[{"name":"Nagoya University , , Furocho , Chikusa, ,","place":["Nagoya, Japan, 464-8603"]},{"name":"Japan Science and Technology Agency , , 4-1-8 Honcho , , ,","place":["Kawaguchi, Saitama, Japan, 332-0012"]},{"name":"Japan Science and Technology Agency , , 4-1-8 Honcho , , ,","place":["Kawaguchi, Saitama, Japan, 332-0012"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0339-1740","authenticated-orcid":true,"family":"Wahyudiono","sequence":"additional","affiliation":[{"name":"Nagoya University , , Furocho , Chikusa, ,","place":["Nagoya, Japan, 464-8603"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4927-0402","authenticated-orcid":true,"given":"Siti","family":"Machmudah","sequence":"additional","affiliation":[{"name":"Institut Teknologi Sepuluh Nopember , , ,","place":["Surabaya, Indonesia, 60111"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3219-5028","authenticated-orcid":true,"given":"Motonobu","family":"Goto","sequence":"additional","affiliation":[{"name":"Nagoya University , , Furocho , Chikusa, ,","place":["Nagoya, Japan, 464-8603"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,9,11]]},"reference":[{"key":"2026090210193407700_cit1","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.foodchem.2018.02.070","article-title":"Analysis of\nfunctional components and radical scavenging activity of 21 algae\nspecies collected from the Japanese coast","volume":"255","author":"Ito","year":"2018","journal-title":"Food\nChem."},{"key":"2026090210193407700_cit2","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1007\/BF00566975","article-title":"Carotenoid composition\nand metabolism in green and blue-green algal","volume":"94","author":"Adams","year":"1993","journal-title":"Oecologia"},{"key":"2026090210193407700_cit3","doi-asserted-by":"publisher","first-page":"51","DOI":"10.2174\/138161212798919101","article-title":"Neuroprotective Effects of Lutein\nin the Retina","volume":"18","author":"Ozawa","year":"2012","journal-title":"Curr. 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