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A new solvatomorph (crystal form C) of DE with dimethyl sulfoxide was identified and characterized for the first time through a thermogravimetry\u2013mass spectrometry (TG\u2013MS) coupling system. The thermodynamic property of the new solvatomorph of DE was different from those of most pharmaceutical solvatomorphs, and it was revealed via the skimmer-type interfaced TG\u2013MS system and differential scanning calorimetry. This new solvatomorph and a polymorph of DE obtained without solvent (crystal form A) were well characterized by X-ray crystallography and vibrational spectroscopic analysis. Computational studies based on their single-crystal structures, such as Hirshfeld surface analyses, were used to determine the intermolecular interactions in the crystal network. The single-crystal structure of crystal form C of DE was determined and reported for the first time.<\/jats:p>","DOI":"10.1021\/acsomega.0c03531","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T10:28:17Z","timestamp":1600943297000},"page":"25289-25296","source":"Crossref","is-referenced-by-count":8,"title":["Characterization of a New Solvatomorph of Drospirenone\nby Thermogravimetry\u2013Mass Spectrometry Combined with Other Solid-State\nAnalysis Methods"],"prefix":"10.1021","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8833-7374","authenticated-orcid":true,"given":"Penghui","family":"Yuan","sequence":"first","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College , , ,","place":["Beijing, China, 100050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3159-4126","authenticated-orcid":true,"given":"Dezhi","family":"Yang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College , , ,","place":["Beijing, China, 100050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3885-221X","authenticated-orcid":true,"given":"Ruonan","family":"Wang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College , , ,","place":["Beijing, China, 100050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningbo","family":"Gong","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College , , ,","place":["Beijing, China, 100050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3115-8196","authenticated-orcid":true,"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College , , ,","place":["Beijing, China, 100050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2274-5703","authenticated-orcid":true,"given":"Yang","family":"Lu","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College , , ,","place":["Beijing, China, 100050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanhua","family":"Du","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College , , ,","place":["Beijing, China, 100050"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,9,24]]},"reference":[{"key":"2026090207565371400_cit1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/s0010-7824(00)00133-5","article-title":"Drospirenone:\npharmacology and pharmacokinetics of a unique progestogen","volume":"62","author":"Krattenmacher","year":"2000","journal-title":"Contraception"},{"key":"2026090207565371400_cit2","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1517\/14656566.8.7.989","article-title":"Drospirenone: a\nnovel progestin","volume":"8","author":"Rapkin","year":"2007","journal-title":"Expet Opin. 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