{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:47:50Z","timestamp":1792640870880,"version":"4.5.0"},"reference-count":58,"publisher":"American Chemical Society (ACS)","issue":"49","license":[{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_ccbyncnd_termsofuse.html"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology , Ministry of Science and Technology","doi-asserted-by":"publisher","award":["BT\/363\/NE\/TBP\/2012"],"award-info":[{"award-number":["BT\/363\/NE\/TBP\/2012"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Antimicrobial agents (AMAs) are widely exploited nowadays to meet the high demand for animal-derived food. It has a significant impact on the food chain whose end consumers are human beings. The burden of AMAs on humans comes from either meat or crops cultivated on soil containing high residual antibiotics, which are responsible for the global crisis of antibiotic resistance. Thus, the objective of this study was to design a selective and sensitive liquid chromatography\u2013mass spectrometry (LC-MS)\/MS-based simultaneous bioanalytical method for estimation of twenty AMAs in human plasma, raw meat, and soil samples. The selective extraction of all analytes from the above matrices was performed by the solid-phase extraction clean-up method to overcome the interferences. Analytes were separated on a Waters Symmetry Shield C18 (150 \u00d7 4.6 mm2, 5 \u03bcm) column, using an isocratic solvent system of methanol\u20130.5% formic acid (80:20, v\/v) with 0.75 mL\/min flow rate. The average extraction recoveries for all analytes in plasma were ranged from 42.0 to 94.0% with relative standard deviations (RSDs) below \u00b115%. All of the validation parameters are in accordance with the United State Food and Drug Administration (USFDA) guidelines. Moreover, the method was also valid for a broad plasma concentration range and can be proposed as an excellent method for routine pharmacokinetic studies, therapeutic drug monitoring, clinical analysis, and detection and quantitation of AMA remnants in raw meat as a standard quality control test for human consumption.<\/jats:p>","DOI":"10.1021\/acsomega.0c03863","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T02:10:15Z","timestamp":1607047815000},"page":"31584-31597","source":"Crossref","is-referenced-by-count":17,"title":["Rapid and Simultaneous Analysis of Multiple Classes\nof Antimicrobial Drugs by Liquid Chromatography-Tandem Mass Spectrometry\nand Its Application to Routine Biomedical, Food, and Soil Analyses"],"prefix":"10.1021","volume":"5","author":[{"given":"Anjali","family":"Mishra","sequence":"first","affiliation":[{"name":"CSIR-Central Drug Research Institute , , ,","place":["Lucknow, India, 226031"]},{"name":"Academy of Scientific & Innovative Research (AcSIR) , Anusandhan Bhawan, Rafi Marg , ,","place":["New Delhi, India, 110 001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashpal Singh","family":"Chhonker","sequence":"additional","affiliation":[{"name":"CSIR-Central Drug Research Institute , , ,","place":["Lucknow, India, 226031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amol Chhatrapati","family":"Bisen","sequence":"additional","affiliation":[{"name":"CSIR-Central Drug Research Institute , , ,","place":["Lucknow, India, 226031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yarra Durga","family":"Prasad","sequence":"additional","affiliation":[{"name":"CSIR-Central Drug Research Institute , , ,","place":["Lucknow, India, 226031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin Laxman","family":"Tulsankar","sequence":"additional","affiliation":[{"name":"CSIR-Central Drug Research Institute , , ,","place":["Lucknow, India, 226031"]},{"name":"Academy of Scientific & Innovative Research (AcSIR) , Anusandhan Bhawan, Rafi Marg , ,","place":["New Delhi, India, 110 001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hardik","family":"Chandasana","sequence":"additional","affiliation":[{"name":"CSIR-Central Drug Research Institute , , ,","place":["Lucknow, India, 226031"]},{"name":"Academy of Scientific & Innovative Research (AcSIR) , Anusandhan Bhawan, Rafi Marg , ,","place":["New Delhi, India, 110 001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tushar","family":"Dey","sequence":"additional","affiliation":[{"name":"ICAR Research Complex for North Eastern Hill Region , , ,","place":["Meghalaya, India, 793103"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarvesh Kumar","family":"Verma","sequence":"additional","affiliation":[{"name":"CSIR-Central Drug Research Institute , , ,","place":["Lucknow, India, 226031"]},{"name":"Jawaharlal Nehru University , ,","place":["New Delhi, India, 110001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veenu","family":"Bala","sequence":"additional","affiliation":[{"name":"Academy of Scientific & Innovative Research (AcSIR) , Anusandhan Bhawan, Rafi Marg , ,","place":["New Delhi, India, 110 001"]},{"name":"CSIR-Central Drug Research Institute , , ,","place":["Lucknow, India, 226031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Kanojiya","sequence":"additional","affiliation":[{"name":"CSIR-Central Drug Research Institute , , ,","place":["Lucknow, India, 226031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Ghatak","sequence":"additional","affiliation":[{"name":"ICAR Research Complex for North Eastern Hill Region , , ,","place":["Meghalaya, India, 793103"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4844-2388","authenticated-orcid":true,"given":"Rabi Sankar","family":"Bhatta","sequence":"additional","affiliation":[{"name":"CSIR-Central Drug Research Institute , , ,","place":["Lucknow, India, 226031"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,12,4]]},"reference":[{"key":"2026092106111281700_cit1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00338","article-title":"Antibiotics\nin the Soil Environment\n- Degradation and their Impact on Microbial Activity and Diversity","volume":"10","author":"Cycon\u0301","year":"2019","journal-title":"Front. 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U.S.A."},{"key":"2026092106111281700_cit5","first-page":"935","article-title":"Occurrence\nand fate of antibiotic and heavy metal resistance genes in the total\nprocess of biological treatment and land application of animal manure:\nA review","volume":"35","author":"Zhang","year":"2015","journal-title":"Acta Sci. Circum."},{"key":"2026092106111281700_cit6","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1016\/j.scitotenv.2017.05.152","article-title":"Occurrence, abundance,\nand distribution of sulfonamide and tetracycline resistance genes\nin agricultural soils across China","volume":"599\u2013600","author":"Zhou","year":"2017","journal-title":"Sci. Total\nEnviron."},{"key":"2026092106111281700_cit7","first-page":"169","article-title":"Therapeutic\nDrug Monitoring\nof Antibiotics in Critically Ill Patients","volume-title":"Handbook of Analytical Separations","author":"Horn","year":"2020"},{"key":"2026092106111281700_cit8","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1515\/cclm-2019-0621","article-title":"Measurement\nuncertainty of \u03b2-lactam antibiotics results: estimation and\nclinical impact on therapeutic drug monitoring","volume":"58","author":"Rigo-Bonnin","year":"2020","journal-title":"Clin. Chem. Lab. Med."},{"key":"2026092106111281700_cit9","doi-asserted-by":"publisher","first-page":"2940","DOI":"10.1021\/ac048512+","article-title":"Simultaneous analysis\nof multiple classes of antibiotics\nby ion trap LC\/MS\/MS for assessing surface water and groundwater contamination","volume":"77","author":"Batt","year":"2005","journal-title":"Anal. 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Agric.\nFood Chem."},{"key":"2026092106111281700_cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2019.108334","article-title":"Reverse\nultrasound-assisted emulsification-microextraction\nof macrolides from chicken fat followed by electrophoretic determination","volume":"113","author":"Lorenzetti","year":"2019","journal-title":"LWT"},{"key":"2026092106111281700_cit22","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.foodchem.2016.03.070","article-title":"Molecularly\nimprinted solid-phase extraction for the\ndetermination of ten macrolide drugs residues in animal muscles by\nliquid chromatography\u2013tandem mass spectrometry","volume":"208","author":"Song","year":"2016","journal-title":"Food Chem."},{"key":"2026092106111281700_cit23","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.jchromb.2016.04.026","article-title":"Simultaneous determination\nof 22 cephalosporins drug residues in\npork muscle using liquid chromatography\u2013tandem mass spectrometry","volume":"1022","author":"Li","year":"2016","journal-title":"J. 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Technol."},{"key":"2026092106111281700_cit44","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.4155\/bio.14.117","article-title":"Simultaneous\ndetermination of ornidazole and its main metabolites in human plasma\nby LC\u2013MS\/MS: application to a pharmacokinetic study","volume":"6","author":"Du","year":"2014","journal-title":"Bioanalysis"},{"key":"2026092106111281700_cit45","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02177-16","article-title":"Assessment\nof clinical pharmacokinetic drug-drug interaction of antimalarial\ndrugs \u03b1\/\u03b2-arteether and sulfadoxine-pyrimethamine","volume":"61","author":"Chhonker","year":"2017","journal-title":"Antimicrob. 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