{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:43:10Z","timestamp":1793299390374,"version":"4.5.0"},"reference-count":14,"publisher":"American Chemical Society (ACS)","issue":"45","license":[{"start":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T00:00:00Z","timestamp":1604361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","award":["15172-402"],"award-info":[{"award-number":["15172-402"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","award":["S2634352"],"award-info":[{"award-number":["S2634352"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hydrogen-peroxide-based low-temperature sterilization is a new sterilization technology for temperature-dependent medical devices. The effect of the process parameters of hydrogen-peroxide-based sterilizer on the sterilization performance of process challenge devices (PCDs) needs to be investigated. Sterilant amount, operating temperature, vacuum pressure, diffusion time, and chamber loading of the sterilizer on the sterilization performance of PCDs were adjusted. Seven PCDs with various morphologies and material containing biological indicators (BI) (EZTest, Geobacillus stearothermophilus) were used to evaluate the sterilization performance. The sterilization success rates of PCDs were 86, 71, and 57% with controlled temperature and pressure, diffusion time, and sterilant volume injection, respectively. The PCD material and structure also obviously affected sterilization performance. The sterilization of PCD A is the least successful for all parameters. Meanwhile, the sterilization of PCD B was influenced by the diffusion time and the sterilant injection volume. PCD B and PCD C were successfully sterilized by controlling the temperature and pressure. The weights and volume of the sterilization loading chamber resulted in a different sterilization performance. Sterilization performances of PCD 1, PCD 2, and PCD 3 were &amp;lt;70, &amp;lt;90, and 100%, respectively. Sterilant volume, sterilant diffusion time, pressure, temperature, PCD types, and chamber loading were proven to be important process parameters of sterilizer that affect the sterilization performance of vaporized-hydrogen-peroxide-based sterilizers.<\/jats:p>","DOI":"10.1021\/acsomega.0c04208","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T02:07:47Z","timestamp":1604369267000},"page":"29382-29387","source":"Crossref","is-referenced-by-count":10,"title":["Evaluation of Sterilization Performance for Vaporized-Hydrogen-Peroxide-Based\nSterilizer with Diverse Controlled Parameters"],"prefix":"10.1021","volume":"5","author":[{"given":"Mi Suk","family":"Noh","sequence":"first","affiliation":[{"name":"Bio-medical & Environ-chemical Division, Korea Testing Certification , , , ,","place":["Gunpo, Gyeonggi-do, Republic of Korea, 15809"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk Hee","family":"Jung","sequence":"additional","affiliation":[{"name":"Bio-medical & Environ-chemical Division, Korea Testing Certification , , , ,","place":["Gunpo, Gyeonggi-do, Republic of Korea, 15809"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ohryun","family":"Kwon","sequence":"additional","affiliation":[{"name":", Bio-medical & Environ-chemical Division, Korea Testing Certification , , , ,","place":["Ochang-eup, Chungcheongbuk-do, Republic of Korea, 28115"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Il","family":"Lee","sequence":"additional","affiliation":[{"name":"LOWTEM Co., Ltd. , , ,","place":["Gunpo, Gyeonggi-do, Republic of Korea, 15850"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Jin","family":"Yang","sequence":"additional","affiliation":[{"name":"Research Institute, CMTECH Co., Ltd. , Dong-Gu, ,","place":["Daegu-City, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunil","family":"Hahm","sequence":"additional","affiliation":[{"name":"Konkuk University , , ,","place":["Seoul, Republic of Korea, 05029"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6556-7946","authenticated-orcid":true,"given":"Bong-Hyun","family":"Jun","sequence":"additional","affiliation":[{"name":"Konkuk University , , ,","place":["Seoul, Republic of Korea, 05029"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,11,3]]},"reference":[{"key":"2026090210014419000_cit1","doi-asserted-by":"publisher","first-page":"e23","DOI":"10.1016\/j.ajic.2016.02.022","article-title":"New developments\nin disinfection and sterilization","volume":"44","author":"Wallace","year":"2016","journal-title":"Am. 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Control"},{"key":"2026090210014419000_cit5","unstructured":"Rutala, W. A.; Weber, D. J.\n          Healthcare; (HICPAC), I. C. P. A. C.\n          Guideline for Disinfection\nand Sterilization in Healthcare Facilities. CDC, 2008."},{"key":"2026090210014419000_cit6","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/0093-691X(95)92391-L","article-title":"Toxic effects\nof ethylene oxide residues\non in vitro production of bovine embryos","volume":"43","author":"Holyoak","year":"1995","journal-title":"Theriogenology"},{"key":"2026090210014419000_cit7","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1002\/jbm.b.10036","article-title":"Residual ethylene\noxide in medical\ndevices and device material","volume":"66B","author":"Lucas","year":"2003","journal-title":"J. Biomed. 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