{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:19:58Z","timestamp":1788351598801,"version":"build-2803163510"},"reference-count":36,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_ccbyncnd_termsofuse.html"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G0A5516"],"award-info":[{"award-number":["G0A5516"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The Strecker reaction is a three-component condensation of an aldehyde, an amine, and hydrogen cyanide, delivering an \u03b1-amino carbonitrile. Despite extensive investigations, the possibility to use amides instead of amines as one of the three condensation partners has been largely neglected. Nonetheless, the N-acylated \u03b1-aminocarbonitriles that are obtained in this way are of direct interest for drug discovery, because they make up a well-known class of mechanism-based inhibitors of serine- and cysteine-type hydrolases. In response, we have thoroughly explored the corresponding variant of the Strecker reaction, focusing on catalyst use, solvent, reaction time, and cyanide source. Optimized parameters were combined in a sequential one-pot protocol for which the scope was found to be compatible with library synthesis applications. Product yields ranged from 7 to 90%, and conditions were found to be mild and tolerant to a wide range of functional groups, including moieties that are typically present in druglike molecules.<\/jats:p>","DOI":"10.1021\/acsomega.0c04908","type":"journal-article","created":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T13:21:38Z","timestamp":1610284898000},"page":"1328-1338","source":"Crossref","is-referenced-by-count":6,"title":["Strecker-Derived Methodology for Library Synthesis\nof\n                    <i>N<\/i>\n                    -Acylated \u03b1-Aminonitriles"],"prefix":"10.1021","volume":"6","author":[{"given":"Pedro","family":"Gonc\u0327alves","sequence":"first","affiliation":[{"name":"University of Antwerp , , Universiteitsplein 1 , ,","place":["Wilrijk, Belgium, 2610"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Peeraer","sequence":"additional","affiliation":[{"name":"University of Antwerp , , Universiteitsplein 1 , ,","place":["Wilrijk, Belgium, 2610"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Adriaenssens","sequence":"additional","affiliation":[{"name":"University of Antwerp , , Universiteitsplein 1 , ,","place":["Wilrijk, Belgium, 2610"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Zonnekein","sequence":"additional","affiliation":[{"name":"University of Antwerp , , Universiteitsplein 1 , ,","place":["Wilrijk, Belgium, 2610"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Franck","sequence":"additional","affiliation":[{"name":"University of Antwerp , , Groenenborgerlaan 171 , ,","place":["Antwerp, Belgium, 2020"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0431-7606","authenticated-orcid":true,"given":"Bert U. W.","family":"Maes","sequence":"additional","affiliation":[{"name":"University of Antwerp , , Groenenborgerlaan 171 , ,","place":["Antwerp, Belgium, 2020"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5203-4339","authenticated-orcid":true,"given":"Koen","family":"Augustyns","sequence":"additional","affiliation":[{"name":"University of Antwerp , , Universiteitsplein 1 , ,","place":["Wilrijk, Belgium, 2610"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1208-3571","authenticated-orcid":true,"given":"Pieter","family":"Van Der Veken","sequence":"additional","affiliation":[{"name":"University of Antwerp , , Universiteitsplein 1 , ,","place":["Wilrijk, Belgium, 2610"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,1,7]]},"reference":[{"key":"2026090207504465500_cit1","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1002\/jlac.18500750103","article-title":"Ueber Die\nKu\u0308nstliche Bildung Der Milchsa\u0308ure Und Einen Neuen, Dem\nGlycocoll Homologen Ko\u0308rper","volume":"75","author":"Strecker","year":"1850","journal-title":"Ann. 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Compounds\nwith Two Carbon Heteroatom Bonds","volume-title":"Science\nof Synthesis","author":"Tehrani","year":"2005"},{"key":"2026090207504465500_cit29","doi-asserted-by":"publisher","first-page":"5759","DOI":"10.1016\/j.tetlet.2006.06.008","article-title":"Cu(OTf)2 or Et3N-Catalyzed Three-Component Condensation\nof Aldehydes, Amines and Cyanides: A High Yielding Synthesis of \u03b1-Aminonitriles","volume":"47","author":"Paraskar","year":"2006","journal-title":"Tetrahedron Lett."},{"key":"2026090207504465500_cit30","doi-asserted-by":"publisher","first-page":"3133","DOI":"10.1055\/s-0028-1087277","article-title":"A Mild and\nEfficient Catalytic Strecker Reaction of N -Alkoxycarbonylamino Sulfones\nwith Trimethylsilyl Cyanide Using Indium(III) Chloride: A Facile Synthesis\nof \u03b1-Aminonitriles","volume":"2008","author":"Das","year":"2008","journal-title":"Synlett"},{"key":"2026090207504465500_cit31","doi-asserted-by":"publisher","first-page":"2548","DOI":"10.1021\/ja058066n","article-title":"Asymmetric Strecker Reaction of Aldimines\nUsing Aqueous Potassium Cyanide by Phase-Transfer Catalysis of Chiral\nQuaternary Ammonium Salts with a Tetranaphthyl Backbone","volume":"128","author":"Ooi","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"2026090207504465500_cit32","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1002\/recl.19650840714","article-title":"The Mannich\nCondensation of Sulfinic Acids, Aldehyde,\nand Ethyl Carbamate II.: The Use of Higher Aldehydes","volume":"84","author":"Engberts","year":"1965","journal-title":"Recl. Trav. Chim. Pays-Bas"},{"key":"2026090207504465500_cit33","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1002\/recl.19660851207","article-title":"The Mannich Condensation\nof Sulfinic\nAcids, Aldehyde, and Ethyl Carbamate: III. The Use of Ethyl N-Monosubstituted\nCarbamates, Ethyl Monothiocarbamates and Ethyl Dithiocarbamates","volume":"85","author":"Engberts","year":"1966","journal-title":"Recl. Trav. Chim. Pays-Bas"},{"key":"2026090207504465500_cit34","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1002\/aoc.3443","article-title":"Design, Synthesis,\nCharacterization\nand Catalytic Performance of a New Cellulose-Based Magnetic Nanocomposite\nin the One-Pot Three-Component Synthesis of \u03b1-Aminonitriles","volume":"30","author":"Maleki","year":"2016","journal-title":"Appl. Organomet. Chem."},{"key":"2026090207504465500_cit35","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.jorganchem.2018.12.002","article-title":"Synthesis and Characterization\nof an Acidic Nanostructure Based on Magnetic Polyvinyl Alcohol as\nan Efficient Heterogeneous Nanocatalyst for the Synthesis of \u03b1-Aminonitriles","volume":"881","author":"Maleki","year":"2019","journal-title":"J. Organomet. 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