{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:08:59Z","timestamp":1791846539426,"version":"4.3.4"},"reference-count":102,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T00:00:00Z","timestamp":1609718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_ccbyncnd_termsofuse.html"}],"funder":[{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["1R15EB024921-01"],"award-info":[{"award-number":["1R15EB024921-01"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Nanostructured surfaces control microbial biofilm formation by killing mechanically via surface architecture. However, the interactions between nanostructured surfaces (NSS) and cellular fungi have not been thoroughly investigated and the application of NSS as a means of controlling fungal biofilms is uncertain. Cellular yeast such as Candida albicans are structurally and biologically distinct from prokaryotic microbes and therefore are predicted to react differently to nanostructured surfaces. The dimorphic opportunistic fungal pathogen, C. albicans, is responsible for most cases of invasive candidiasis and is a serious health concern due to the rapid increase of drug resistance strains. In this paper, we show that the nanostructured surfaces from a cicada wing alter C. albicans\u2019 viability, biofilm formation, adhesion, and morphogenesis through physical contact. However, the fungal cell response to the NSS suggests that nanoscale mechanical interactions impact C. albicans differently than prokaryotic microbes. This study informs on the use of nanoscale architecture for the control of eukaryotic biofilm formation and illustrates some potential caveats with the application of NSS as an antimicrobial means.<\/jats:p>","DOI":"10.1021\/acsomega.0c04980","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T14:45:35Z","timestamp":1609771535000},"page":"1361-1369","source":"Crossref","is-referenced-by-count":18,"title":["Cell Rupture and Morphogenesis\nControl of the Dimorphic\nYeast\n                    <i>Candida albicans<\/i>\n                    by Nanostructured\nSurfaces"],"prefix":"10.1021","volume":"6","author":[{"given":"Naga Venkatesh","family":"Kollu","sequence":"first","affiliation":[{"name":"University of North Carolina Greensboro , , , ,","place":["Greensboro, North Carolina, United States, 27401"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5049-8968","authenticated-orcid":true,"given":"Dennis R.","family":"LaJeunesse","sequence":"additional","affiliation":[{"name":"University of North Carolina Greensboro , , , ,","place":["Greensboro, North Carolina, United States, 27401"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,1,4]]},"reference":[{"key":"2026090208015524100_cit1","doi-asserted-by":"publisher","DOI":"10.1093\/femsyr\/fov081","article-title":"Candida albicans commensalism\nin the gastrointestinal tract","volume":"15","author":"Neville","year":"2015","journal-title":"FEMS Yeast Res."},{"key":"2026090208015524100_cit2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00081","article-title":"New Insights in Candida albicans Innate Immunity at the Mucosa: Toxins, Epithelium,\nMetabolism, and Beyond","volume":"10","author":"Pellon","year":"2020","journal-title":"Front. 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