{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:02:31Z","timestamp":1789988551796,"version":"4.0.1"},"reference-count":54,"publisher":"American Chemical Society (ACS)","issue":"50","license":[{"start":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T00:00:00Z","timestamp":1607558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_ccbyncnd_termsofuse.html"}],"funder":[{"name":"Santalis Pharmaceuticals Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\u03b1- and \u03b2-Santalol (santalol isomers) are the most abundant sesquiterpenoids found in sandalwood, contributing to its pleasant fragrance and wide-spectrum bioactivity. This study aimed at identifying the antiaging and antiaggregation mechanism of \u03b1- and \u03b2-santalol using the genetic tractability of an in vivo model Caenorhabditis elegans. The results showed that santalol isomers retard aging, improved health span, and inhibited the aggregation of toxic amyloid-\u03b2 (A\u03b21\u201342) and polyglutamine repeats (Q35, Q40, and HtnQ150) in C. elegans models for Alzheimer\u2019s and Huntington\u2019s disease, respectively. The genetic study, reporter gene expression, RNA-based reverse genetic approach (RNA interferences\/RNAi), and gene expression analysis revealed that santalol isomers selectively regulate SKN-1\/Nrf2 and EOR-1\/PLZF transcription factors through the RTK\/Ras\/MAPK-dependent signaling axis that could trigger the expression of several antioxidants and protein aggregation inhibitory genes, viz., gst-4, gcs-1, gst-10, gsr-1, hsp-4, and skr-5, which extend longevity and help minimize age-induced protein oxidation and aggregation. We believe that these findings will further promote \u03b1- and \u03b2-santalol to become next-generation prolongevity and antiaggregation molecules for longer and healthier life.<\/jats:p>","DOI":"10.1021\/acsomega.0c05006","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T23:52:08Z","timestamp":1607644328000},"page":"32641-32654","source":"Crossref","is-referenced-by-count":28,"title":["\u03b1- and \u03b2-Santalols Delay Aging\nin\n                    <i>Caenorhabditis elegans<\/i>\n                    via Preventing\nOxidative Stress and Protein Aggregation"],"prefix":"10.1021","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7840-4716","authenticated-orcid":true,"given":"Amirthalingam","family":"Mohankumar","sequence":"first","affiliation":[{"name":"Bharathiar University , , , ,","place":["Coimbatore, Tamilnadu, India, 641046"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duraisamy","family":"Kalaiselvi","sequence":"additional","affiliation":[{"name":"Bharathiar University , , , ,","place":["Coimbatore, Tamilnadu, India, 641046"]},{"name":"Chonnam National University , , ,","place":["Gwangju, Republic of Korea, 61186"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govindhan","family":"Thiruppathi","sequence":"additional","affiliation":[{"name":"Bharathiar University , , , ,","place":["Coimbatore, Tamilnadu, India, 641046"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivaramakrishnan","family":"Muthusaravanan","sequence":"additional","affiliation":[{"name":"Kumaraguru College of Technology , , , ,","place":["Coimbatore, Tamilnadu, India, 641049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sundararaj","family":"Nivitha","sequence":"additional","affiliation":[{"name":"Northeastern University , , , ,","place":["Boston, Massachusetts, United States, 02115"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey","family":"Levenson","sequence":"additional","affiliation":[{"name":"Santalis Pharmaceuticals, Inc. , 18618 Tuscany Stone, Suite 100 , , ,","place":["San Antonio, Texas, United States, 78258"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinkichi","family":"Tawata","sequence":"additional","affiliation":[{"name":"University of the Ryukyus , , Senbaru 1 , Nishihara-cho, ,","place":["Okinawa, Japan, 903-0213"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palanisamy","family":"Sundararaj","sequence":"additional","affiliation":[{"name":"Bharathiar University , , , ,","place":["Coimbatore, Tamilnadu, India, 641046"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,12,10]]},"reference":[{"key":"2026092106135019600_cit1","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1126\/science.1172539","article-title":"Extending healthy life span-from\nyeast to humans","volume":"328","author":"Fontana","year":"2010","journal-title":"Science"},{"key":"2026092106135019600_cit2","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks\nof aging","volume":"153","author":"Lo\u0301pez-Oti\u0301n","year":"2013","journal-title":"Cell"},{"key":"2026092106135019600_cit3","doi-asserted-by":"publisher","first-page":"6029","DOI":"10.1074\/jbc.R116.751164","article-title":"Non-enzymatic\nmolecular damage as\na prototypic driver of aging","volume":"292","author":"Golubev","year":"2017","journal-title":"J. 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