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In vitro studies comprised egg albumin and bovine serum albumin protein denaturation assays along with membrane stabilization assays, while in vivo studies comprised formaldehyde and complete Freund\u2019s adjuvant (CFA)-provoked arthritis. The antioxidant potential was estimated via DPPH free radical scavenging and ferric reducing assays. Rosuvastatin significantly inhibited heat-provoked protein denaturation of egg albumin and bovine serum in a concentration-dependent way with the highest inhibition of 1225 \u00b1 9.83 and 82.80 \u00b1 4.03 at 6400 \u03bcg\/mL. The percentage protection of the RBC membrane from hypotonicity-prompted lysis was found to be 80.67 \u00b1 2.7. Rosuvastatin promisingly subdued formaldehyde-provoked arthritis, with maximum reduction (65.47%) of the paw volume being observed at a dose of 40 mg\/kg. Rosuvastatin also significantly (p &amp;lt; 0.001) attenuated arthritis induced by CFA injection by reducing the paw volume and arthritic index. The reduction in the body weight due to CFA injection was also preserved by rosuvastatin treatment. Hematological and biochemical changes due to arthritis induction by CFA injection were also maintained near normal values by rosuvastatin. The histopathological and radiographic investigation also revealed the protective effect of rosuvastatin on preventing structural changes. Gene expression of IL-1\u03b2, TNF-\u03b1, and IL-6 was reduced, while IL-4 and IL-10 levels were elevated by rosuvastatin in comparison to those for the disease control group. Concentration-dependent antioxidant potential was shown by rosuvastatin. Thus, rosuvastatin possesses a notable antiarthritic potential as evidenced via in vitro and in vivo studies.<\/jats:p>","DOI":"10.1021\/acsomega.0c05054","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T23:47:44Z","timestamp":1610668064000},"page":"2074-2084","source":"Crossref","is-referenced-by-count":34,"title":["RETRACTED: Rosuvastatin Attenuates Rheumatoid Arthritis-Associated\nManifestations via Modulation of the Pro- and Anti-inflammatory Cytokine\nNetwork: A Combination of\n                    <i>In Vitro<\/i>\n                    and\n                    <i>In Vivo<\/i>\n                    Studies"],"prefix":"10.1021","volume":"6","author":[{"given":"Sumera","family":"Qasim","sequence":"first","affiliation":[{"name":"Jouf University , , , ,","place":["Sakaka, Aljouf, Saudi Arabia, 2014"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4775-7337","authenticated-orcid":true,"family":"Alamgeer","sequence":"additional","affiliation":[{"name":"University of the Punjab , , ,","place":["Lahore, Pakistan, 54590"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima","family":"Kalsoom","sequence":"additional","affiliation":[{"name":"SA-CIRBS International Islamic University , ,","place":["Islamabad, Pakistan, 44000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Shahzad","sequence":"additional","affiliation":[{"name":"University of Health Sciences , , ,","place":["Lahore, Pakistan, 54590"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishfaq Ali","family":"Bukhari","sequence":"additional","affiliation":[{"name":"King Saud University Riyadh , , ,","place":["Riyadh, Saudi Arabia, 11451"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahim","family":"Vohra","sequence":"additional","affiliation":[{"name":"King Saud University , , ,","place":["Riyadh, Saudi Arabia, 11451"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibtain","family":"Afzal","sequence":"additional","affiliation":[{"name":"King Saud University Riyadh , , ,","place":["Riyadh, Saudi Arabia, 11451"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,1,14]]},"reference":[{"key":"2026102809063942000_cit1","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/S0140-6736(09)60008-8","article-title":"Rheumatoid arthritis","volume":"373","author":"Klareskog","year":"2009","journal-title":"Lancet"},{"key":"2026102809063942000_cit2","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.intimp.2011.11.012","article-title":"Anti-inflammatory\nand antioxidative effects of mucilage of Trigonella foenum graecum\n(Fenugreek) on adjuvant induced arthritic rats","volume":"12","author":"Sindhu","year":"2012","journal-title":"Int. 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Pharmacol."},{"key":"2026102809063942000_cit42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/959687","article-title":"Therapeutic effects of acetone extract\nof saraca asoca seeds on rats with adjuvant-induced arthritis via\nattenuating inflammatory responses","volume":"2014","author":"Gupta","year":"2014","journal-title":"ISRN Rheumatol."},{"key":"2026102809063942000_cit43","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.ejphar.2014.05.045","article-title":"Anti-arthritic\nactivity of N0-[(2,4-dihydroxyphenyl)methylidene]-2-(3,4-dimethyl-5,5-dioxidopyrazolo[4,3-c][1,2]benzothiazin-1\n(4H)-yl)acetohydrazide","volume":"738","author":"Shabbir","year":"2014","journal-title":"Eur. J. 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