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The chemical composition of the products was established on the basis of spectral and elemental analyses. Aurora B kinase is a protein with diverse biological actions in controlling tumorigenesis by inhibiting apoptosis and promoting proliferation and metastasis, making it an emerging target for diseases such as hepatocellular carcinoma (HCC). Alteration in the target protein expression causes unequal distribution of genetic information, causing HCC. The new compounds were tested for their antihepatic cancer activity, and some of them had strong efficacy against human hepatoblastoma (HepG2) cell lines.<\/jats:p>","DOI":"10.1021\/acsomega.0c05116","type":"journal-article","created":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T22:39:09Z","timestamp":1609886349000},"page":"1445-1455","source":"Crossref","is-referenced-by-count":37,"title":["Synthesis, Anticancer Evaluation, Computer-Aided Docking\nStudies, and ADMET Prediction of 1,2,3-Triazolyl-Pyridine Hybrids\nas Human Aurora B Kinase Inhibitors"],"prefix":"10.1021","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7474-1678","authenticated-orcid":true,"given":"Huda R.M.","family":"Rashdan","sequence":"first","affiliation":[{"name":"National Research Centre , , Dokki, ,","place":["Cairo, Egypt, 12622"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihsan A.","family":"Shehadi","sequence":"additional","affiliation":[{"name":"University of Sharjah , , ,","place":["Sharjah, UAE, 27272"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abobakr H.","family":"Abdelmonsef","sequence":"additional","affiliation":[{"name":"South Valley University , , ,","place":["Qena, Egypt, 83523"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,1,5]]},"reference":[{"key":"2026090209122551200_cit1","first-page":"729","article-title":"Synthesis of some new\nazolotriazine, 4-arylazopyrazole and pyridine derivatives containing\n1, 2, 3-triazole moiety","volume":"1","author":"Abdelhamid","year":"2013","journal-title":"Int. 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