{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:04:22Z","timestamp":1789427062528,"version":"build-2803163510"},"reference-count":43,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_ccbyncnd_termsofuse.html"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>New derivatives of [1,3,4]oxadiazole-2-thione and triazole-3-thione were synthesized through the cyclocondensation of dicarbonyl ester 2 with phenyl hydrazine followed by hydrazinolysis to give the corresponding hydrazide, which reacted with carbon disulfide or ammonium thiocyanate to afford [1,3,4]oxadiazole 5 or triazole-3-thione 7, respectively. Hydrazinolysis of compound 5 gave [1,2,4]triazole-3-thiol 9 which was treated with different aromatic aldehydes to obtain 10a\u2013c. Mannich bases 11a\u2013c were obtained from the reaction of Schiff bases 10a\u2013c with morpholine and formaldehyde. Moreover, treatment of triazole-3-thione 7 with hydrazine was followed by cyclocondensation with diethyl oxalate, chloroacetic acid, or formic acid to give the corresponding [1,2,4]triazine-3,4-dione 14, [1,2,4]triazin-4-one 15, or [1,2,4]triazolo[4,3-b][1,2,4] triazole 16, respectively. Screening of some chosen synthesized compounds against the human colon carcinoma cancer cell lines showed that the compound [1,2,4]triazole-3-thiol 9 exhibiting cytotoxic activity was roughly equivalent to standard Vinblastine, while compounds 4, 7, 10, 11a, 14, and 16 exhibited moderate cytotoxic activity.<\/jats:p>","DOI":"10.1021\/acsomega.0c05718","type":"journal-article","created":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T02:07:36Z","timestamp":1610244456000},"page":"1687-1696","source":"Crossref","is-referenced-by-count":37,"title":["Synthesis and Screening of New [1,3,4]Oxadiazole,\n[1,2,4]Triazole, and [1,2,4]Triazolo[4,3-\n                    <i>b<\/i>\n                    ][1,2,4]triazole Derivatives as Potential Antitumor Agents on the\nColon Carcinoma Cell Line (HCT-116)"],"prefix":"10.1021","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3082-2545","authenticated-orcid":true,"given":"El-sayed M.","family":"Abdelrehim","sequence":"first","affiliation":[{"name":"Damanhour University , , ,","place":["Damanhour, Egypt, 22511"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,1,7]]},"reference":[{"key":"2026090211000892500_cit1","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1002\/jhet.3058","article-title":"Synthesis of Some\nNovel Pyrido[2,3-d]pyrimidine and\nPyrido[3,2-e][1,3,4]triazolo and Tetrazolo[1,5-c]pyrimidine Derivatives\nas Potential Antimicrobial and Anticancer Agents","volume":"55","author":"Abdelrehim","year":"2018","journal-title":"J. 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