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The crystal structure of complex C3 has been determined. The complexes show several absorption bands in the visible and ultraviolet regions, and they also show prominent emission in the visible region while excited near 400 nm. Studies on the interaction of ligands L1\u2013L3 and complexes C1\u2013C3 with calf thymus DNA reveal that the complexes are better DNA binders than the ligands, which is attributable to the imposed planarity of the ruthenium-bound guanidine-based ligand, enabling it to serve as a better intercalator. Molecular docking studies show that the complexes effectively bind with DNA through electrostatic and H-bonding interactions and partial intercalation of the guanidine-based ligands. Cytotoxicity studies carried out on two carcinoma cell lines (PC3 and A549) and on two non-cancer cell lines (BPH1 and WI-38) show a marked improvement in antitumor activity owing to complex formation, which is attributed to improvement in cellular uptake on complex formation. The C1 complex is found to exhibit the most prominent activity against the PC3 cell line. Inclusion of the guanidine-based ligands in the half-sandwich ruthenium\u2013arene complexes is found to be effective for displaying selective cytotoxicity to cancer cells and also for convenient tracing of the complexes in cells due to their prominent emissive nature.<\/jats:p>","DOI":"10.1021\/acsomega.0c06265","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T15:32:27Z","timestamp":1616167947000},"page":"8226-8238","source":"Crossref","is-referenced-by-count":19,"title":["Utilization of Guanidine-Based Ancillary Ligands in\nArene\u2013Ruthenium Complexes for Selective Cytotoxicity"],"prefix":"10.1021","volume":"6","author":[{"given":"Jit","family":"Karmakar","sequence":"first","affiliation":[{"name":"Jadavpur University , , ,","place":["Kolkata, India, 700 032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Promita","family":"Nandy","sequence":"additional","affiliation":[{"name":"Jadavpur University , , ,","place":["Kolkata, India, 700 032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0455-8760","authenticated-orcid":true,"given":"Saurabh","family":"Das","sequence":"additional","affiliation":[{"name":"Jadavpur University , , ,","place":["Kolkata, India, 700 032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debalina","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Maulana Azad College , , ,","place":["Kolkata, India, 700 013"]},{"name":"Jadavpur University , , ,","place":["Kolkata, India, 700 032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parimal","family":"Karmakar","sequence":"additional","affiliation":[{"name":"Jadavpur University , , ,","place":["Kolkata, India, 700 032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6245-9752","authenticated-orcid":true,"given":"Samaresh","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Jadavpur University , , ,","place":["Kolkata, India, 700 032"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,3,19]]},"reference":[{"key":"2026081414152062600_cit1a","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1021\/acs.chemrev.8b00493","article-title":"Intracellular\nCatalysis with Selected Metal Complexes and Metallic Nanoparticles:\nAdvances toward the Development of Catalytic Metallodrugs","volume":"119","author":"Soldevila-Barreda","year":"2019","journal-title":"Chem. 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