{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:25:45Z","timestamp":1786980345833,"version":"build-2736575974"},"reference-count":32,"publisher":"American Chemical Society (ACS)","issue":"50","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015507","name":"Shandong First Medical University","doi-asserted-by":"publisher","award":["2019LJ003"],"award-info":[{"award-number":["2019LJ003"]}],"id":[{"id":"10.13039\/501100015507","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sulfonamides and lipids are widely found in natural products, bioactive substances, and pharmaceuticals. Here, we report N-sulfonylation and esterification of carboxylic acids in an environment-friendly one-pot tandem protocol involving 1,2-dichloroethane (DCE). Moreover, 1,8-diazabicyclo (5.4.0) undec-7-ene was necessary for this reaction as a strong base, which drives the reaction to completion. Although DCE is a very low activity reagent, it acts not only as a solvent but also as a reactant in the reaction. The \u03b2-chloroester contained in the reaction product can be easily dissociated to react with N, S, and O atoms, increasing the possibility for subsequent synthesis.<\/jats:p>","DOI":"10.1021\/acsomega.1c05331","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T14:31:31Z","timestamp":1638887491000},"page":"34796-34804","source":"Crossref","is-referenced-by-count":6,"title":["Base-Mediated Coupling Reactions of Benzenesulfonyl\nAzides with Proline: Synthesis of Proline-Derived Benzenesulfonamides"],"prefix":"10.1021","volume":"6","author":[{"given":"Hongyan","family":"Liu","sequence":"first","affiliation":[{"name":"Shandong First Medical University & Shandong Academy of Medical Sci-ences , , ,","place":["Taian, China, 271016"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong Agricultural University , , ,","place":["Taian, China, 271018"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shandong First Medical University & Shandong Academy of Medical Sci-ences , , ,","place":["Taian, China, 271016"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Yu","sequence":"additional","affiliation":[{"name":"Shandong First Medical University & Shandong Academy of Medical Sci-ences , , ,","place":["Taian, China, 271016"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Shandong First Medical University & Shandong Academy of Medical Sci-ences , , ,","place":["Taian, China, 271016"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1943-5720","authenticated-orcid":true,"given":"Chengcai","family":"Xia","sequence":"additional","affiliation":[{"name":"Shandong First Medical University & Shandong Academy of Medical Sci-ences , , ,","place":["Taian, China, 271016"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Shandong First Medical University & Shandong Academy of Medical Sci-ences , , ,","place":["Taian, China, 271016"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,12,7]]},"reference":[{"key":"2026081710243764100_cit1","doi-asserted-by":"publisher","first-page":"3237","DOI":"10.1016\/j.cclet.2020.08.046","article-title":"Cp*Co\u00ad(III)-catalyzed\nC-H amidation of azines with dioxazolones","volume":"31","author":"Huang","year":"2020","journal-title":"Chin.\nChem. 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Lett."},{"key":"2026081710243764100_cit6","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.ejmech.2018.05.017","article-title":"Synthesis\nof proline derived benzenesulfonamides:\nA potent anti-Trypanosoma brucei gambiense agent","volume":"154","author":"Ugwu","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"2026081710243764100_cit7","unstructured":"Kulman, D. G.; Lama, R.; Li, B.; Su, B.\n          Evaluation of the selectivity\nof sulfonamide\ntubulin inhibitors against human African trypanosomiasis; Cleveland State University, 2017. Retrieved\non 22nd February 22. www.csuohio.edu\/sites\/default\/files\/29-%202015.pdf."},{"key":"2026081710243764100_cit8","doi-asserted-by":"publisher","first-page":"131662","DOI":"10.1016\/j.tet.2020.131662","article-title":"Synthesis of sulfonamide\nand their synthetic and therapeutic\napplications: Recent advances","volume":"76","author":"Mondal","year":"2020","journal-title":"Tetrahedron"},{"key":"2026081710243764100_cit9","doi-asserted-by":"publisher","first-page":"2564","DOI":"10.1021\/ol200660s","article-title":"Mild Pd-catalyzed N-arylation\nof methanesulfonamide and related nucleophiles: Avoiding potentially\ngenotoxic reagents and byproducts","volume":"13","author":"Rosen","year":"2011","journal-title":"Org. 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Chem."},{"key":"2026081710243764100_cit15","doi-asserted-by":"publisher","first-page":"2370","DOI":"10.1021\/acs.orglett.5b00866","article-title":"Chemoselective intramolecular\nfunctionalization of\nmethyl groups in nonconstrained molecules promoted by N-Iodosulfonamides","volume":"17","author":"Paz","year":"2015","journal-title":"Org. Lett."},{"key":"2026081710243764100_cit16","doi-asserted-by":"publisher","first-page":"7485","DOI":"10.1002\/anie.201901673","article-title":"Intermolecular\nradical C\u00ad(sp3)-H amination\nunder Iodine catalysis","volume":"58","author":"Bosnidou","year":"2019","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026081710243764100_cit17","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1021\/acs.orglett.0c00081","article-title":"Halogen-bond-induced\nconsecutive\nCsp3-H aminations via hydrogen atom transfer relay strategy","volume":"22","author":"Wu","year":"2020","journal-title":"Org. 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Lett."},{"key":"2026081710243764100_cit25","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1002\/asia.201500808","article-title":"Palladium-catalyzed\nthioetherification of quinolone derivatives via\ndecarboxylative C\u2013S cross-couplings","volume":"11","author":"Xia","year":"2016","journal-title":"Chem.\ue5f8Asian J."},{"key":"2026081710243764100_cit26","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1007\/s12094-013-1127-9","article-title":"Proteomic analysis\nof differentially\nexpressed proteins in 5-fluorouracil-treated human breast cancer MCF-7\ncells","volume":"16","author":"Cai","year":"2014","journal-title":"Clin. Transl. Oncol."},{"key":"2026081710243764100_cit27","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1246\/bcsj.51.2401","article-title":"A convenient\nprocedure for esterification of carboxylic acids","volume":"51","author":"Ono","year":"1978","journal-title":"Bull. Chem. Soc."}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.1c05331","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/6\/50\/34796\/3669455\/ao1c05331.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/6\/50\/34796\/3669455\/ao1c05331.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:37:15Z","timestamp":1786977435000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/acsodf\/article\/6\/50\/34796\/381185\/Base-Mediated-Coupling-Reactions-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,7]]},"references-count":32,"journal-issue":{"issue":"50","published-online":{"date-parts":[[2021,12,7]]},"published-print":{"date-parts":[[2021,12,21]]}},"URL":"https:\/\/doi.org\/10.1021\/acsomega.1c05331","relation":{},"ISSN":["2470-1343"],"issn-type":[{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,7]]}}}