{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:46:11Z","timestamp":1789623971650,"version":"build-2803163510"},"reference-count":60,"publisher":"American Chemical Society (ACS)","issue":"27","license":[{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004242","name":"Princess Nourah Bint Abdulrahman University","doi-asserted-by":"publisher","award":["Researchers Supporting Project number (PNURSP2022R108)"],"award-info":[{"award-number":["Researchers Supporting Project number (PNURSP2022R108)"]}],"id":[{"id":"10.13039\/501100004242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The fustin plant-derived bioflavonoid obtained from a common plant known as lacquer tree from family Anacardiaceae, formally known as Rhus verniciflua Stokes, is known to exert a variety of therapeutic properties. The current investigation proved the anti-ulcerative property of fustin on ethanol-induced gastric ulcers in an experimental animal model. The fustin 50 and 100 mg\/kg was studied in an experimental rat model by performing an 8 day protocol. The ulcer index, pH, total acidic content, and biochemical parameters such as glutathione (GSH), superoxide dismutase (SOD), catalase activity (CAT), malondialdehyde (MDA), interleukin-1\u03b2, prostaglandin E-2, tumor necrosis factor-\u03b1 (TNF-\u03b1), myeloperoxidase, and nitric oxide (NO) in serum were measured. The gastric parameter such as ulcer index, pH, and acidic content was maintained in the fustin groups compared to the ethanol control group. Clinical presentation of gastric ulcers includes a significant increase in serum levels, GSH, SOD, and CAT and decreased MDA, TNF-\u03b1, interleukin-1\u03b2, and prostaglandin E-2 parameters in contrast to normal groups. The treatment regimen with fustin has significantly restored all serum parameters in test groups. The current study helps to develop reasonable phytochemical options for the innervations of chemical-induced gastric ulcers.<\/jats:p>","DOI":"10.1021\/acsomega.2c01341","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T14:52:35Z","timestamp":1656600755000},"page":"23245-23254","source":"Crossref","is-referenced-by-count":33,"title":["Protective Effect of Fustin Against Ethanol-Activated\nGastric Ulcer via Downregulation of Biochemical Parameters in Rats"],"prefix":"10.1021","volume":"7","author":[{"given":"Sadaf\nJamal","family":"Gilani","sequence":"first","affiliation":[{"name":"Princess Nourah Bint Abdulrahman University , , ,","place":["Riyadh, Saudi Arabia, 11671"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May Nasser","family":"Bin-Jumah","sequence":"additional","affiliation":[{"name":"Princess Nourah Bint Abdulrahman University , , ,","place":["Riyadh, Saudi Arabia, 11671"]},{"name":"Princess Nourah Bint Abdulrahman University , , ,","place":["Riyadh, Saudi Arabia, 11671"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahad A.","family":"Al-Abbasi","sequence":"additional","affiliation":[{"name":"King Abdulaziz University ,","place":["Jeddah, Saudi Arabia, 21589"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Shahid","family":"Nadeem","sequence":"additional","affiliation":[{"name":"King Abdulaziz University ,","place":["Jeddah, Saudi Arabia, 21589"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8913-0826","authenticated-orcid":true,"given":"Syed Sarim","family":"Imam","sequence":"additional","affiliation":[{"name":"King Saud University , , ,","place":["Riyadh, Saudi Arabia, 11451"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0922-9819","authenticated-orcid":true,"given":"Sultan","family":"Alshehri","sequence":"additional","affiliation":[{"name":"King Saud University , , ,","place":["Riyadh, Saudi Arabia, 11451"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Muqtader","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Prince Sattam Bin Abdulaziz University , , ,","place":["Al-Kharj, Saudi\nArabia, 11942"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed M.","family":"Ghoneim","sequence":"additional","affiliation":[{"name":"AlMaarefa University , , ,","place":["Ad Diriyah, Saudi Arabia, 13713"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2570-3223","authenticated-orcid":true,"given":"Muhammad","family":"Afzal","sequence":"additional","affiliation":[{"name":"Jouf University , , ,","place":["Aljouf, Sakaka, Saudi Arabia, 72341"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami I.","family":"Alzarea","sequence":"additional","affiliation":[{"name":"Jouf University , , ,","place":["Aljouf, Sakaka, Saudi Arabia, 72341"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadeem","family":"Sayyed","sequence":"additional","affiliation":[{"name":"Glocal University , , ,","place":["Saharanpur, India, 247121"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1881-5219","authenticated-orcid":true,"given":"Imran","family":"Kazmi","sequence":"additional","affiliation":[{"name":"King Abdulaziz University ,","place":["Jeddah, Saudi Arabia, 21589"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"2026081710112976700_cit1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.cbi.2013.11.011","article-title":"Protective effect\nof chelerythrine against ethanol-induced\ngastric ulcer in mice","volume":"208","author":"Li","year":"2014","journal-title":"Chem.-Biol. 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Biomed.\nBiotechnol."},{"key":"2026081710112976700_cit27","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1271\/bbb.130236","article-title":"Protective\neffect of detoxified Rhus verniciflua stokes on human keratinocytes\nand dermal fibroblasts against oxidative stress and identification\nof the bioactive phenolics","volume":"77","author":"Liu","year":"2013","journal-title":"Biosci., Biotechnol.,\nBiochem."},{"key":"2026081710112976700_cit28","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1055\/s-2003-45097","article-title":"Antirheumatoid\narthritis effect of\nRhus verniciflua and of the active component, sulfuretin","volume":"69","author":"Choi","year":"2003","journal-title":"Planta Med."},{"key":"2026081710112976700_cit29","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jep.2003.09.043","article-title":"Antimutagenic activity\nof flavonoids from the heartwood of Rhus verniciflua","volume":"90","author":"Park","year":"2004","journal-title":"J. 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DC (Asteraceae)\u00ad(Marcela),\na folk medicine plant, in different experimental models","volume":"130","author":"Santin","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"2026081710112976700_cit38","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/s0022-3476(68)80202-1","article-title":"Erythrocyte\nglutathione-peroxidase\ndeficiencyand hemolytic disease of the newborn infant","volume":"72","author":"Necheles","year":"1968","journal-title":"J. Pediatr."},{"key":"2026081710112976700_cit39","first-page":"305","article-title":"Evaluation\nof lipid peroxidation by assaying the thiobarbituric acid-reactive\nsubstances","volume":"56","author":"Lefevre","year":"1998","journal-title":"Ann. Biol. Clin."},{"key":"2026081710112976700_cit40","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/s0076-6879(84)05016-3","article-title":"[13] Catalase\nin vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"2026081710112976700_cit41","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/0009-8981(79)90211-0","article-title":"A simplified assay method of superoxide\ndismutase activity\nfor clinical use","volume":"92","author":"Masayasu","year":"1979","journal-title":"Clin. Chim. Acta"},{"key":"2026081710112976700_cit42","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1111\/1523-1747.ep12506462","article-title":"Measurement\nof cutaneous inflammation: estimation of neutrophil content with an\nenzyme marker","volume":"78","author":"Bradley","year":"1982","journal-title":"J. Invest. Dermatol."},{"key":"2026081710112976700_cit43","doi-asserted-by":"publisher","first-page":"167","DOI":"10.5455\/jeim.200312.or.024","article-title":"Comparison\nof two different applications of the Griess method for nitric oxide\nmeasurement","volume":"2","author":"Yucel","year":"2012","journal-title":"J. Exp. Integr. Med."},{"key":"2026081710112976700_cit44","volume-title":"Theory and Practice of\nHistological Techniques","author":"Bancroft","year":"2008"},{"key":"2026081710112976700_cit45","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1186\/s12906-019-2760-9","article-title":"Antiulcerogenic\neffect of Cuphea ignea extract against ethanol-induced gastric ulcer\nin rats","volume":"19","author":"Mousa","year":"2019","journal-title":"BMC Complementary Altern. Med."},{"key":"2026081710112976700_cit46","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1186\/1472-6882-13-183","article-title":"Gastroprotective effect of desmosdumotin\nC isolated\nfrom Mitrella kentii against ethanol-induced gastric mucosal hemorrhage\nin rats: possible involvement of glutathione, heat-shock protein-70,\nsulfhydryl compounds, nitric oxide, and anti-Helicobacter pylori activity","volume":"13","author":"Sidahmed","year":"2013","journal-title":"BMC Complementary Altern. Med."},{"key":"2026081710112976700_cit47","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1111\/j.1440-1746.2008.05333.x","article-title":"Artemisia\nasiatica extracts protect against ethanol-induced injury in gastric\nmucosa of rats","volume":"23","author":"Park","year":"2008","journal-title":"Gastroenterol. Hepatol."},{"key":"2026081710112976700_cit48","doi-asserted-by":"publisher","first-page":"121786","DOI":"10.1155\/2013\/121786","article-title":"Heavy ethanol intoxication\nincreases proinflammatory\ncytokines and aggravates hemorrhagic shock-induced organ damage in\nrats","volume":"2013","author":"Hu","year":"2013","journal-title":"Mediators Inflammation"},{"key":"2026081710112976700_cit49","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.taap.2013.05.035","article-title":"Protective effect of\ntetrahydrocoptisine against ethanol-induced\ngastric ulcer in mice","volume":"272","author":"Li","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"2026081710112976700_cit50","first-page":"345","article-title":"Total flavonoid\nfrom Ba lotus leaf protected the reserpine-induced gastric ulcer in\nmice","volume":"28","author":"Zhao","year":"2017","journal-title":"Biomed. Res."},{"key":"2026081710112976700_cit51","doi-asserted-by":"publisher","first-page":"137","DOI":"10.3390\/biom9040137","article-title":"Preventive\neffect of Anji White tea flavonoids on alcohol-induced gastric injury\nthrough their antioxidant effects in kunming mice","volume":"9","author":"Liu","year":"2019","journal-title":"Biomolecules"},{"key":"2026081710112976700_cit52","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1159\/000198694","article-title":"Effect of\nethanol on peptic activity in the rat stomach","volume":"23","author":"Puurunen","year":"1982","journal-title":"Digestion"},{"key":"2026081710112976700_cit53","doi-asserted-by":"publisher","first-page":"596920","DOI":"10.1155\/2014\/596920","article-title":"Protective\neffect of flos lonicerae against experimental gastric ulcers in rats:\nmechanisms of antioxidant and anti-inflammatory action","volume":"2014","author":"Kang","year":"2014","journal-title":"J. Evidence-Based Complementary Altern. 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