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The present study reports in situ photo-on-demand phosgenation reactions of amino acids with CHCl3 for synthesizing NCAs. A series of NCAs were obtained on a gram scale upon photo-irradiation of a mixture solution of CHCl3 and CH3CN containing an amino acid at 60\u201370 \u00b0C under O2 bubbling. This method presents a safe and convenient reaction controlled by light without special apparatuses and reagents.<\/jats:p>","DOI":"10.1021\/acsomega.2c05299","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T16:16:00Z","timestamp":1666196160000},"page":"39250-39257","source":"Crossref","is-referenced-by-count":13,"title":["Photo-On-Demand\nSynthesis of \u03b1\u2011Amino\nAcid\n                    <i>N<\/i>\n                    \u2011Carboxyanhydrides with Chloroform"],"prefix":"10.1021","volume":"7","author":[{"given":"Toshiyuki","family":"Sugimoto","sequence":"first","affiliation":[{"name":"Kobe University , , 1-1 Rokkodai-cho , Nada-ku, ,","place":["Kobe, Japan, 657-8501"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Kuwahara","sequence":"additional","affiliation":[{"name":"Kobe University , , 1-1 Rokkodai-cho , Nada-ku, ,","place":["Kobe, Japan, 657-8501"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengying","family":"Liang","sequence":"additional","affiliation":[{"name":"Kobe University , , 1-1 Rokkodai-cho , Nada-ku, ,","place":["Kobe, Japan, 657-8501"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huirong","family":"Wang","sequence":"additional","affiliation":[{"name":"Kobe University , , 1-1 Rokkodai-cho , Nada-ku, ,","place":["Kobe, Japan, 657-8501"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9232-1455","authenticated-orcid":true,"given":"Akihiko","family":"Tsuda","sequence":"additional","affiliation":[{"name":"Kobe University , , 1-1 Rokkodai-cho , Nada-ku, ,","place":["Kobe, Japan, 657-8501"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2022,10,19]]},"reference":[{"key":"2026081709235992400_cit1a","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1002\/cber.190603901133","article-title":"Ueber die Glycin-carbonsa\u0308ure","volume":"39","author":"Leuchs","year":"1906","journal-title":"Ber. 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