{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:45:26Z","timestamp":1786977926454,"version":"build-2736575974"},"reference-count":57,"publisher":"American Chemical Society (ACS)","issue":"45","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM133764"],"award-info":[{"award-number":["R35GM133764"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U54DK110858"],"award-info":[{"award-number":["U54DK110858"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000875","name":"Pew Charitable Trusts","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100000875","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Viscoelastic flow has been widely used in microfluidic particle separation processes, in which particles get focused on the channel center in diluted viscoelastic flow. In this paper, the transition from single-stream focusing to multiple-streams focusing (MSF) in high viscoelastic flow is observed, which is applied for cell separation processes. Particle focusing stream bifurcation is caused by the balance between elastic force and viscoelastic secondary flow drag force. The influence of cell physical properties, such as cell dimension, shape, and deformability, on the formation of multiple-streams focusing is studied in detail. Particle separation is realized utilizing different separation criteria. The size-based separation of red (RBC) and white (WBC) blood cells is demonstrated in which cells get focused in different streams based on their dimension difference. Cells with different deformabilities get stretched in the viscoelastic flow, leading to the change of focusing streams, and this property is harnessed to separate red blood cells infected with the malaria parasite, Plasmodium falciparum. The achieved results promote our understanding of particle movement in the high viscoelastic flow and enable new particle manipulation and separation processes for sample treatment in biofluids.<\/jats:p>","DOI":"10.1021\/acsomega.2c06021","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T13:31:23Z","timestamp":1667395883000},"page":"41759-41767","source":"Crossref","is-referenced-by-count":11,"title":["Multiple-Streams\nFocusing-Based Cell Separation in\nHigh Viscoelasticity Flow"],"prefix":"10.1021","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1350-4841","authenticated-orcid":true,"given":"Haidong","family":"Feng","sequence":"first","affiliation":[{"name":"University of Utah , , , ,","place":["Salt Lake\nCity, Utah, United States, 84112"]},{"name":"Massachusetts Institute of Technology , , , ,","place":["Cambridge, Massachusetts, United States, 02139"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhruv","family":"Patel","sequence":"additional","affiliation":[{"name":"University of Utah , , , ,","place":["Salt Lake\nCity, Utah, United States, 84112"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jules J.","family":"Magda","sequence":"additional","affiliation":[{"name":"University of Utah , , , ,","place":["Salt Lake City, Utah, United States, 84112"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sage","family":"Geher","sequence":"additional","affiliation":[{"name":"University of Utah School of Medicine , , , ,","place":["Salt Lake City, Utah, United States, 84112"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3464-3042","authenticated-orcid":true,"given":"Paul A.","family":"Sigala","sequence":"additional","affiliation":[{"name":"University of Utah School of Medicine , , , ,","place":["Salt Lake City, Utah, United States, 84112"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5843-3464","authenticated-orcid":true,"given":"Bruce K.","family":"Gale","sequence":"additional","affiliation":[{"name":"University of Utah , , , ,","place":["Salt Lake\nCity, Utah, United States, 84112"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"key":"2026081709251224000_cit1","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1039\/b712784g","article-title":"Continuous\nflow separations in microfluidic devices","volume":"7","author":"Pamme","year":"2007","journal-title":"Lab\nChip"},{"key":"2026081709251224000_cit2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10404-013-1291-9","article-title":"Particle separation\nand sorting in microfluidic devices:\na review","volume":"17","author":"Sajeesh","year":"2014","journal-title":"Microfluid. 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