{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T02:31:56Z","timestamp":1793673116521,"version":"4.5.1"},"reference-count":47,"publisher":"American Chemical Society (ACS)","issue":"14","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["2019-6039"],"award-info":[{"award-number":["2019-6039"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology , Ministry of Science and Technology","doi-asserted-by":"publisher","award":["BT\/PR31715\/BIC\/101\/1233\/2019"],"award-info":[{"award-number":["BT\/PR31715\/BIC\/101\/1233\/2019"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2023,4,11]]},"DOI":"10.1021\/acsomega.3c00225","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T17:11:15Z","timestamp":1680023475000},"page":"13026-13037","source":"Crossref","is-referenced-by-count":34,"title":["Identification of Novel Tau-Tubulin Kinase 2 Inhibitors Using Computational Approaches"],"prefix":"10.1021","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2009-7367","authenticated-orcid":true,"given":"Shahzaib","family":"Ahamad","sequence":"first","affiliation":[{"name":"Translational Bioinformatics Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi 110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanipakam","family":"Hema","sequence":"additional","affiliation":[{"name":"Translational Bioinformatics Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi 110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7548-8835","authenticated-orcid":true,"given":"Dinesh","family":"Gupta","sequence":"additional","affiliation":[{"name":"Translational Bioinformatics Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi 110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,3,28]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201412075"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201811142"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0463"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-018-0237-9"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/575170"},{"key":"ref6\/cit6","unstructured":"Taylor, L. M. Understanding the role and regulation of TTBK1\/2 during neurodegenerative disease progression. Ph.D. Thesis, University of Washington, 2018."},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14866"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-020-01073-7"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1039\/d0ra07659g"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2014.00033"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.10.010"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26486"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2012.11.014"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004803"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/575170"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-020-00875-6"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.5b00559"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1075"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.softx.2015.06.001"},{"key":"ref20\/cit20","unstructured":"Schr\u00f6dinger, R. Maestro; Schr\u00f6dinger; LLC: New York, NY, 2020."},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1042\/bj20110276"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky427"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1107\/s0907444998009378"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3289"},{"key":"ref25\/cit25","unstructured":"DeLano, W. L. Pymol: An open-source molecular graphics tool.  CCP4 Newsletter on Protein Crystallography, 2002; Vol. 40(1), pp 82\u201392."},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/ja9621760"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.6026\/97320630014015"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/jm030644s"},{"key":"ref29\/cit29","unstructured":"Schr\u00f6dinger, L. QikProp, version 3.5; Schr\u00f6dinger: New York, NY, 2012."},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1039\/c5ra12869b"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444904011679"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20291"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.5b00935"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1063\/1.4943956"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1111\/biom.12641"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1002\/wics.101"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.30112"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1049"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-2836(05)80360-2"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1098\/rsta.2012.0488"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.0c02747"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.6b00523"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.6b01509"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2020.127891"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/ja983494x"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2017.12.014"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1039\/c5ra20552b"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.3c00225","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.3c00225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T08:37:01Z","timestamp":1681202221000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.3c00225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,28]]},"references-count":47,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2023,4,11]]}},"alternative-id":["10.1021\/acsomega.3c00225"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.3c00225","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"value":"2470-1343","type":"print"},{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,28]]}}}