{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T07:06:17Z","timestamp":1792307177177,"version":"4.4.0"},"reference-count":51,"publisher":"American Chemical Society (ACS)","issue":"20","license":[{"start":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:00:00Z","timestamp":1683849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["1944\/20"],"award-info":[{"award-number":["1944\/20"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006245","name":"Ministry of Science and Technology, Israel","doi-asserted-by":"publisher","award":["3-14316"],"award-info":[{"award-number":["3-14316"]}],"id":[{"id":"10.13039\/501100006245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Antibiotic-resistant bacterial infections have increased the prevalence of sepsis and septic shock mortality worldwide and have become a global concern. Antimicrobial peptides (AMPs) show remarkable properties for developing new antimicrobial agents and host response modulatory therapies. A new series of AMPs derived from pexiganan (MSI-78) were synthesized. The positively charged amino acids were segregated at their N- and C-termini, and the rest of the amino acids created a hydrophobic core surrounded by positive charges and were modified to simulate the lipopolysaccharide (LPS). The peptides were investigated for their antimicrobial activity and LPS-induced cytokine release inhibition profile. Various biochemical and biophysical methods were used, including attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, microscale thermophoresis (MST), and electron microscopy. Two new AMPs, MSI-Seg-F2F and MSI-N7K, preserved their neutralizing endotoxin activity while reducing toxicity and hemolytic activity. Combining all of these properties makes the designed peptides potential candidates to eradicate bacterial infection and detoxify LPS, which might be useful for sepsis treatment.<\/jats:p>","DOI":"10.1021\/acsomega.3c00850","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T11:46:07Z","timestamp":1683891967000},"page":"17856-17868","source":"Crossref","is-referenced-by-count":22,"title":["Interaction of\nPexiganan (MSI-78)-Derived Analogues\nReduces Inflammation and TLR4-Mediated Cytokine Secretion: A Comparative\nStudy"],"prefix":"10.1021","volume":"8","author":[{"given":"Hadar","family":"Cohen","sequence":"first","affiliation":[{"name":"The Weizmann Institute of Science , , ,","place":["Rehovot, Israel, 76100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1150-1794","authenticated-orcid":true,"given":"Naiem Ahmad","family":"Wani","sequence":"additional","affiliation":[{"name":"The Weizmann Institute of Science , , ,","place":["Rehovot, Israel, 76100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5679-5696","authenticated-orcid":true,"given":"Daniel","family":"Ben Hur","sequence":"additional","affiliation":[{"name":"The Weizmann Institute of Science , , ,","place":["Rehovot, Israel, 76100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovico","family":"Migliolo","sequence":"additional","affiliation":[{"name":"Universidade Cato\u0301lica Dom Bosco , , ,","place":["Campo Grande, Brazil, 79117-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6676-5362","authenticated-orcid":true,"given":"Marlon H.","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Universidade Cato\u0301lica Dom Bosco , , , ,","place":["Campo Grande, MS, Brazil, 79117900"]},{"name":"Universidade Cato\u0301lica de Brasi\u0301lia , , , ,","place":["Brasi\u0301lia, DF, Brazil, 70790160"]},{"name":"Universidade Federal de Mato Grosso do Sul , , Cidade Universita\u0301ria , , ,","place":["Campo Grande, Mato Grosso do Sul, Brazil, 79070900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziv","family":"Porat","sequence":"additional","affiliation":[{"name":"The Weizmann Institute of Science , , ,","place":["Rehovot, Israel, 76100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Shimoni","sequence":"additional","affiliation":[{"name":"The Weizmann Institute of Science , , ,","place":["Rehovot, Israel, 76100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9546-0525","authenticated-orcid":true,"given":"Octavio Luiz","family":"Franco","sequence":"additional","affiliation":[{"name":"Universidade Cato\u0301lica Dom Bosco , , ,","place":["Campo Grande, Brazil, 79117-900"]},{"name":"Universidade Cato\u0301lica Dom Bosco , , , ,","place":["Campo Grande, MS, Brazil, 79117900"]},{"name":"Universidade Cato\u0301lica de Brasi\u0301lia , , , ,","place":["Brasi\u0301lia, DF, Brazil, 70790160"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8588-5586","authenticated-orcid":true,"given":"Yechiel","family":"Shai","sequence":"additional","affiliation":[{"name":"The Weizmann Institute of Science , , ,","place":["Rehovot, Israel, 76100"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,5,12]]},"reference":[{"key":"2026081708233860700_cit1","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.4049\/jimmunol.1000376","article-title":"LL-37 directs macrophage differentiation\ntoward macrophages with a proinflammatory signature","volume":"185","author":"van\nder Does","year":"2010","journal-title":"J. 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Chemother."},{"key":"2026081708233860700_cit26","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1021\/bi900724x","article-title":"Effect of the hydrophobicity to net positive charge\nratio on antibacterial and anti-endotoxin activities of structurally\nsimilar antimicrobial peptides","volume":"49","author":"Rosenfeld","year":"2010","journal-title":"Biochemistry"},{"key":"2026081708233860700_cit27","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1128\/AAC.48.5.1593-1599.2004","article-title":"Biophysical\ncharacterization of endotoxin inactivation by NK-2, an antimicrobial\npeptide derived from mammalian NK-lysin","volume":"48","author":"Andra\u0308","year":"2004","journal-title":"Antimicrob.\nAgents Chemother."},{"key":"2026081708233860700_cit28","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.557902","article-title":"Outer membrane\nvesicles of gram-negative bacteria: An outlook on biogenesis","volume":"12","author":"Avila-Caldero\u0301n","year":"2021","journal-title":"Front. 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Leukocyte Biol."},{"key":"2026081708233860700_cit31","doi-asserted-by":"publisher","first-page":"21991","DOI":"10.1074\/jbc.M109.013573","article-title":"Designed \u03b2-Boomerang\nAntiendotoxic and Antimicrobial Peptides: Structures and Activities\nin Lipopolysaccharide","volume":"284","author":"Bhunia","year":"2009","journal-title":"J. Biol. Chem."},{"key":"2026081708233860700_cit32","doi-asserted-by":"publisher","first-page":"W407","DOI":"10.1093\/nar\/gkm290","article-title":"ProSA-web: interactive web service\nfor the recognition\nof errors in three-dimensional structures of proteins","volume":"35","author":"Wiederstein","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"2026081708233860700_cit33","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1369\/0022155412453052","article-title":"Imaging flow cytometry: coping with\nheterogeneity in biological systems","volume":"60","author":"Barteneva","year":"2012","journal-title":"J. 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Commun."},{"key":"2026081708233860700_cit48","first-page":"722","article-title":"PROCHECK: validation of protein-structure\ncoordinates","volume":"25.2","author":"Laskowski","year":"2006","journal-title":"Int. Tables Crystallogr."},{"key":"2026081708233860700_cit49","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving\nthe speed and accuracy of\ndocking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"2026081708233860700_cit50","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3502514","article-title":"Insights into\nthe molecular mechanisms\nof protein-ligand interactions by molecular docking and molecular\ndynamics simulation: A case of oligopeptide binding protein","volume":"2018","author":"Fu","year":"2018","journal-title":"Comput. Math. Methods Med."},{"key":"2026081708233860700_cit51","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05242-0","article-title":"Structural basis for endotoxin neutralisation and anti-inflammatory\nactivity of thrombin-derived C-terminal peptides","volume":"9","author":"Saravanan","year":"2018","journal-title":"Nat. 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