{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:25:06Z","timestamp":1786969506456,"version":"build-2736575974"},"reference-count":52,"publisher":"American Chemical Society (ACS)","issue":"25","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Indazolones possess interesting pharmacological activities. The search for indazole and indazolone-containing nuclei as drugs is an important research area of medicinal chemistry. The current work aims to evaluate a novel indazolone derivative against in vivo and in silico targets of pain, neuropathy, and inflammation. An indazolone derivative (ID) was synthesized and characterized using advanced spectroscopic techniques. Well-established animal models of abdominal constriction, hot plate, tail immersion, carrageenan paw edema, and Brewer\u2019s yeast-induced pyrexia were employed for evaluating the potential of the ID at different doses (20\u201360 mg kg\u20131). Nonselective GABA antagonists, opioid antagonist naloxone (NLX) and pentylenetetrazole (PTZ), were employed to assess the potential role of GABAergic and opioidergic processes. The antineuropathic potential of the drug was evaluated using a vincristine-induced neuropathic pain model. In silico studies were performed to assess any possible interactions of the ID with pain target sites like cyclooxygenases (COX-I\/II), GABAA, and opioid receptors. This study revealed that the selected ID (doses of 20\u201360 mg kg\u20131) efficiently hampered chemically and thermally induced nociceptive responses, producing significant anti-inflammatory and antipyretic effects. These effects produced by the ID were dose-dependent (i.e., 20\u201360 mg kg\u20131 and p range of 0.001\u20130.01) and significant in comparison to standards (p &amp;lt; 0.001). Antagonistic studies with NLX (1.0 mg kg\u20131) and PTZ (15.0 mg kg\u20131) revealed the involvement of the opioidergic mechanism rather than the GABAergic mechanism. The ID showed promising anti-static allodynia effects as well. In silico studies revealed preferential binding interactions of the ID with cyclooxygenases (COX-I\/II), GABAA, and opioid receptors. According to the results of the current investigation, the ID may serve in the future as a therapeutic agent for the treatment of pyrexia, chemotherapy-induced neuropathic pain, and nociceptive inflammatory pain.<\/jats:p>","DOI":"10.1021\/acsomega.3c01717","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T09:47:20Z","timestamp":1686563240000},"page":"22809-22819","source":"Crossref","is-referenced-by-count":10,"title":["Involvement of\nthe Opioidergic Mechanism in the Analgesic\nPotential of a Novel Indazolone Derivative: Efficacy in the Management\nof Pain, Neuropathy, and Inflammation Using\n                    <i>In Vivo<\/i>\n                    and\n                    <i>In Silico<\/i>\n                    Approaches"],"prefix":"10.1021","volume":"8","author":[{"given":"Qarib","family":"Ullah","sequence":"first","affiliation":[{"name":"Hazara University , , ,","place":["Mansehra, Pakistan, 21310"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zarshad","family":"Ali","sequence":"additional","affiliation":[{"name":"Hazara University , , ,","place":["Mansehra, Pakistan, 21310"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2419-3172","authenticated-orcid":true,"given":"Umer","family":"Rashid","sequence":"additional","affiliation":[{"name":"COMSATS University Islamabad-Abbottabad Campus , , ,","place":["Abbottabad, Pakistan, 22060"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gowhar","family":"Ali","sequence":"additional","affiliation":[{"name":"University of Peshawar , , ,","place":["Peshawar, Pakistan, 25120"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisar","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Institute of Health Sciences Mardan , , , ,","place":["Mardan, KPK, Pakistan, 23200"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasool","family":"Khan","sequence":"additional","affiliation":[{"name":"Institute of Chemical Sciences, University of Peshawar , ,","place":["Peshawar, Pakistan, 25120"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Ullah","sequence":"additional","affiliation":[{"name":"University of Peshawar , , ,","place":["Peshawar, Pakistan, 25120"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4299-2445","authenticated-orcid":true,"given":"Muhammad","family":"Ayaz","sequence":"additional","affiliation":[{"name":"University of Malakand , , Dir (L) , , ,","place":["Chakdara, KP, Pakistan, 18000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2361-086X","authenticated-orcid":true,"given":"H C Ananda","family":"Murthy","sequence":"additional","affiliation":[{"name":"Adama Science and Technology University , , P O Box 1888, , ,","place":["Adama, Oromia, Ethiopia, 1888"]},{"name":"Saveetha University , , , ,","place":["Chennai, Tamil Nadu, India, 600077"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,6,12]]},"reference":[{"key":"2026081707213783800_cit1","doi-asserted-by":"publisher","first-page":"5431","DOI":"10.3390\/molecules27175431","article-title":"Efficacy of 2-Hydroxyflavanone\nin rodent models of pain and inflammation: involvement of opioidergic\nand GABAergic anti-nociceptive mechanisms","volume":"27","author":"Khan","year":"2022","journal-title":"Molecules"},{"key":"2026081707213783800_cit2","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.pain.2004.12.010","article-title":"Comparison of pain syndromes associated\nwith nervous or somatic lesions and development of a new neuropathic\npain diagnostic questionnaire (DN4)","volume":"114","author":"Bouhassira","year":"2005","journal-title":"Pain"},{"key":"2026081707213783800_cit3","first-page":"226","article-title":"Classification\nof chronic pain: descriptions of chronic pain syndromes and definitions\nof pain terms","author":"Merskey","year":"1986","journal-title":"Pain"},{"key":"2026081707213783800_cit4","first-page":"1","article-title":"New drug development\nprocess-Today: A review","volume":"1","author":"Ali","year":"2013","journal-title":"Pharmacologyonline"},{"key":"2026081707213783800_cit5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev.med.59.090506.155819","article-title":"The FDA critical path\ninitiative and its influence\non new drug development","volume":"59","author":"Woodcock","year":"2008","journal-title":"Annu. Rev. Med."},{"key":"2026081707213783800_cit6","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1021\/ol203020x","article-title":"A New Route to Indazolone\nvia Amidation\nReaction of o-Carboxyazobenzene","volume":"14","author":"Li","year":"2012","journal-title":"Org. Lett."},{"key":"2026081707213783800_cit7","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s11030-015-9583-5","article-title":"Efficient synthesis of highly substituted tetrahydroindazolone\nderivatives","volume":"19","author":"Scala","year":"2015","journal-title":"Mol. Diversity"},{"key":"2026081707213783800_cit8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF03179922","article-title":"Synthesis and antiinflammatory activity\nof novel indazolones","volume":"26","author":"Abouzid","year":"2003","journal-title":"Arch. Pharmacal Res."},{"key":"2026081707213783800_cit9","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/ardp.19963290107","article-title":"The Anti-inflammatory\nActivity of N-Substituted Indazolones in Mice","volume":"329","author":"Tse","year":"1996","journal-title":"Arch. Pharm."},{"key":"2026081707213783800_cit10","first-page":"433","article-title":"Synthesis\nand biological study of some novel Schiff\u2019s bases of indazolone\nderivatives","volume":"2","author":"Muthumani","year":"2010","journal-title":"J. Chem. Pharm. Res."},{"key":"2026081707213783800_cit11","unstructured":"Oelschlager, H.; Matthiesen, U.; Behrendt, W. A.\n          Analgesic compositions comprising 1H-or respectively\n2H-indazolone-3\n(\u03b2-morpholino-alkoxy) compounds. 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Biol."},{"key":"2026081707213783800_cit27","first-page":"2287","article-title":"Synthesis of pyrrolidine-2,\n5-dione based anti-inflammatory drug:\nin vitro COX-2, 5-LOX inhibition and in vivo anti-inflammatory studies","volume":"38","author":"Jan","year":"2019","journal-title":"Lat. Am. J. Pharm."},{"key":"2026081707213783800_cit28","doi-asserted-by":"publisher","first-page":"585","DOI":"10.5897\/AJPP12.893","article-title":"Pharmacological evaluation, molecular\ndocking and dynamics simulation studies of salicyl alcohol nitrogen\ncontaining derivatives","volume":"7","author":"Ali","year":"2013","journal-title":"Afr. J. Pharm. 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Struct."},{"key":"2026081707213783800_cit37","first-page":"807","article-title":"Chemical characterization\nand analgesic potential of Notholirion\nthomsonianum extract","volume":"38","author":"Mahmood","year":"2019","journal-title":"Lat. Am. J. Pharm."},{"key":"2026081707213783800_cit38","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1007\/s00210-021-02118-x","article-title":"Pharmacological\nevaluation of the\ngabapentin salicylaldehyde derivative, gabapentsal, against tonic\nand phasic pain models, inflammation, and pyrexia","volume":"394","author":"Ahmad","year":"2021","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"2026081707213783800_cit39","doi-asserted-by":"publisher","first-page":"34493","DOI":"10.1038\/srep34493","article-title":"Electroacupuncture\nin conscious free-moving mice reduces pain by ameliorating peripheral\nand central nociceptive mechanisms","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. 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Dyn."},{"key":"2026081707213783800_cit51","doi-asserted-by":"publisher","first-page":"100","DOI":"10.3390\/bioengineering10010100","article-title":"In-silico\nlead druggable compounds identification against SARS COVID-19 main\nprotease target from in-house, chembridge and zinc databases by structure-based\nvirtual screening, molecular docking and molecular dynamics simulations","volume":"10","author":"Ghufran","year":"2023","journal-title":"Bioengineering"},{"key":"2026081707213783800_cit52","doi-asserted-by":"publisher","first-page":"4884","DOI":"10.3390\/cancers14194884","article-title":"In Silico Strategies\nfor Designing of Peptide Inhibitors of Oncogenic K-Ras G12V Mutant:\nInhibiting Cancer Growth and Proliferation","volume":"14","author":"Ghufran","year":"2022","journal-title":"Cancers"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.3c01717","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/8\/25\/22809\/4394405\/ao3c01717.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/8\/25\/22809\/4394405\/ao3c01717.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T11:29:32Z","timestamp":1786966172000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/acsodf\/article\/8\/25\/22809\/407411\/Involvement-of-the-Opioidergic-Mechanism-in-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,12]]},"references-count":52,"journal-issue":{"issue":"25","published-online":{"date-parts":[[2023,6,12]]},"published-print":{"date-parts":[[2023,6,27]]}},"URL":"https:\/\/doi.org\/10.1021\/acsomega.3c01717","relation":{},"ISSN":["2470-1343"],"issn-type":[{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,12]]}}}