{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:23:08Z","timestamp":1793305388327,"version":"4.5.0"},"reference-count":64,"publisher":"American Chemical Society (ACS)","issue":"25","license":[{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007414","name":"Qassim University","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100007414","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The aim of this study was devoted into molecular docking calculations to discover the potential antileishmania and antitoxoplasma activities of newly synthesized compounds obtained by applying a practical and simple method under microwave irradiation. All these compounds were tested in vitro for their biological activity against Leishmania major promastigotes, amastigotes, and Toxoplasma gondii tachyzoites. Compounds 2a, 5a, and 5e were the most active against both L. major promastigotes and amastigotes, with IC50 values of less than 0.4 \u03bcM mL\u20131. Compounds 2c, 2e, 2h, and 5d had a strong antitoxoplasma activity of less than 2.1 \u03bcM mL\u20131 against T. gondii. We can conclude that aromatic methyleneisoindolinones are potently active against both L. major and T. gondii. Further studies for mode of action evaluation are recommended. Compounds 5c and 5b are the best drug candidates for antileishmania and antitoxoplasma due to their SI values being over 13. The docking studies of compounds 2a-h and 5a-e against pteridine reductase 1 and T. gondii enoyl acyl carrier protein reductase reveal that compound 5e may be an effective antileishmanial and antitoxoplasma drug discovery initiative.<\/jats:p>","DOI":"10.1021\/acsomega.3c02362","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T09:08:44Z","timestamp":1686301724000},"page":"23067-23077","source":"Crossref","is-referenced-by-count":8,"title":["Copper-Catalyzed Asymmetric Hydroboration Reaction\nof Novel Methylene Isoindolinone Compounds through Microwave Irradiation\nand Their Antileishmanial and Antitoxoplasma Activities"],"prefix":"10.1021","volume":"8","author":[{"given":"Hamida","family":"Jellali","sequence":"first","affiliation":[{"name":"University of Carthage , , Hammam-Lif , ,","place":["Tunis, Tunisia, 2078"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasser","family":"Amri","sequence":"additional","affiliation":[{"name":"Jazan University , , ,","place":["Jazan, Saudi Arabia, 45142"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef E.","family":"Mukhrish","sequence":"additional","affiliation":[{"name":"Jazan University , , ,","place":["Jazan, Saudi Arabia, 45142"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim S.","family":"Al Nasr","sequence":"additional","affiliation":[{"name":"Qassim University , , ,","place":["Unaizah, Saudi Arabia, 51911"]},{"name":"Qassim University , , ,","place":["Ar Rass, Saudi Arabia, 51921"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed S.","family":"Koko","sequence":"additional","affiliation":[{"name":"Qassim University , , ,","place":["Ar Rass, Saudi Arabia, 51921"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq A.","family":"Khan","sequence":"additional","affiliation":[{"name":"Qassim University , , ,","place":["Ar Rass, Saudi Arabia, 51921"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Deniau","sequence":"additional","affiliation":[{"name":"University of Lille, CNRS, Centrale Lille, Universite\u0301 Artois, UMR 8181\ue5f8UCCS\ue5f8Unite\u0301 de Catalyze et Chimie du Solide , ,","place":["Lille, France, 59000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Sauthier","sequence":"additional","affiliation":[{"name":"University of Lille, CNRS, Centrale Lille, Universite\u0301 Artois, UMR 8181\ue5f8UCCS\ue5f8Unite\u0301 de Catalyze et Chimie du Solide , ,","place":["Lille, France, 59000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houcine","family":"Ghalla","sequence":"additional","affiliation":[{"name":"University of Monastir , , ,","place":["Monastir, Tunisia, 5000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0110-9588","authenticated-orcid":true,"given":"Naceur","family":"Hamdi","sequence":"additional","affiliation":[{"name":"Qassim University , ,","place":["Ar Rass, Saudi Arabia, 51921"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"2026081708281850900_cit1","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1002\/bdd.2510160906","article-title":"Enantioselective pharmacokinetics\nin animals of pazinaclone, a new isoindoline anxiolytic, and its active\nmetabolite","volume":"16","author":"Kondo","year":"1995","journal-title":"Biopharm Drug Dispos."},{"key":"2026081708281850900_cit2","doi-asserted-by":"publisher","first-page":"2526","DOI":"10.1021\/jm00069a011","article-title":"Selective\nnon-nucleoside HIV-1 reverse transcriptase inhibitors. New 2,3-dihydrothiazolo\u00ad[2,3-a]\u00adisoindol-5\u00ad(9bH)-ones\nand related compounds with anti-HIV-1 activity","volume":"36","author":"Mertens","year":"1993","journal-title":"J. Med. Chem."},{"key":"2026081708281850900_cit3","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1021\/np400301d","article-title":"On the Antibiotic\nand Antifungal\nActivity of Pestalone, Pestalachloride A, and Structurally Related\nCompounds","volume":"76","author":"Augner","year":"2013","journal-title":"J. Nat. Prod."},{"key":"2026081708281850900_cit4","doi-asserted-by":"publisher","first-page":"3036","DOI":"10.1016\/j.bmcl.2009.04.020","article-title":"Synthesis of aristolactam analogues\nand evaluation of their antitumor activity","volume":"19","author":"Choi","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"2026081708281850900_cit5a","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.3762\/bjoc.15.104","article-title":"Multicomponent reactions\n(MCRs): a useful access to the synthesis of benzo-fused \u03b3-lactams","volume":"15","author":"de\nMarigorta","year":"2019","journal-title":"Beilstein J. Org. Chem."},{"key":"2026081708281850900_cit5b","doi-asserted-by":"publisher","first-page":"2302","DOI":"10.2174\/138527212803520254","article-title":"Active Methylene\nCompounds in the Synthesis of 3-substituted Isobenzofuranones, Isoindolinones\nand Related Compounds","volume":"16","author":"Di Mola","year":"2012","journal-title":"Curr. Org. Chem."},{"key":"2026081708281850900_cit5c","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1002\/asia.201900080","article-title":"Catalytic\nAsymmetric Synthesis of Isoindolinones","volume":"14","author":"Gao","year":"2019","journal-title":"Chem.\ue5f8Asian\nJ."},{"key":"2026081708281850900_cit5d","doi-asserted-by":"publisher","first-page":"3342","DOI":"10.1002\/adsc.201900246","article-title":"Front Cover Picture: A Sulfone-Containing\nImidazolium-Based Br\u00f8nsted Acid Ionic Liquid Catalyst Enables\nReplacing Dipolar Aprotic Solvents with Butyl Acetate","volume":"361","author":"El Harairy","year":"2019","journal-title":"Adv. Synth. Catal."},{"key":"2026081708281850900_cit5e","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1021\/acs.joc.6b02970","article-title":"Isoindolinones via Copper-Catalyzed\nIntramolecular Benzylic C\u2013H Sulfamidation","volume":"82","author":"Bedford","year":"2017","journal-title":"J. Org. Chem."},{"key":"2026081708281850900_cit5f","doi-asserted-by":"publisher","first-page":"6831","DOI":"10.1021\/acs.joc.7b00975","article-title":"Ruthenium-Catalyzed Carbonylation of Oxalyl Amide-Protected\nBenzylamines with Isocyanate as the Carbonyl Source","volume":"82","author":"Han","year":"2017","journal-title":"J. Org. Chem."},{"key":"2026081708281850900_cit5g","doi-asserted-by":"publisher","first-page":"12990","DOI":"10.1021\/jacs.5b07424","article-title":"Cobalt-Catalyzed\nCyclization of Aliphatic Amides and Terminal Alkynes with Silver-Cocatalyst","volume":"137","author":"Zhang","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"2026081708281850900_cit5h","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1021\/ol9000922","article-title":"Assembly of Substituted 3-Methyleneisoindolin-1-ones\nvia a CuI\/l-Proline-Catalyzed Domino Reaction Process of 2-Bromobenzamides\nand Terminal Alkynes","volume":"11","author":"Li","year":"2009","journal-title":"Org. Lett."},{"key":"2026081708281850900_cit5i","doi-asserted-by":"publisher","first-page":"3483","DOI":"10.1016\/s0040-4039(03)00670-1","article-title":"A new and practical PIFA-promoted\nolefin amidohydroxylation: six- versus five-membered ring formation","volume":"44","author":"Serna","year":"2003","journal-title":"Tetrahedron Lett."},{"key":"2026081708281850900_cit6","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1002\/(sici)1099-1077(199709\/10)12:5&lt;445::aid-hup887&gt;3.0.co;2-2","article-title":"Randomized, double-blind, placebo-controlled\ntrial of the efficacy and tolerability of a new isoindoline derivative\n(DN-2327) in generalized anxiety","volume":"12","author":"Linden","year":"1997","journal-title":"Hum. Psychopharmacol."},{"key":"2026081708281850900_cit7","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1021\/jm9502201","article-title":"Effect\nof Linking Bridge Modifications\non the Antipsychotic Profile of Some Phthalimide and Isoindolinone\nDerivatives","volume":"39","author":"Norman","year":"1996","journal-title":"J. Med. Chem."},{"key":"2026081708281850900_cit8a","doi-asserted-by":"publisher","first-page":"2623","DOI":"10.1021\/jo00088a057","article-title":"Synthesis and Anti-HSV Activity of A-Ring-Deleted Mappicine\nKetone Analog","volume":"59","author":"Pendrak","year":"1994","journal-title":"J. Org. Chem."},{"key":"2026081708281850900_cit8b","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1021\/jm00014a001","article-title":"Toward Improved Anti-HIV Chemotherapy: Therapeutic Strategies for\nIntervention with HIV Infections","volume":"38","author":"De\nClercq","year":"1995","journal-title":"J. Med. Chem."},{"key":"2026081708281850900_cit9","first-page":"1","article-title":"Front Cover\nPicture: Gold-Catalyzed Intermolecular Oxidative Diyne Cyclizations\nvia 1,6-Carbene Transfer","volume":"362","author":"Wei","year":"2020","journal-title":"Adv. Synth. Catal."},{"key":"2026081708281850900_cit10","doi-asserted-by":"publisher","first-page":"5492","DOI":"10.1021\/acs.joc.9b00452","article-title":"Phosphazene\nSuperbase-Mediated Regio- and Stereoselective\nIodoaminocyclization of 2-(1-Alkynyl)\u00adbenzamides for the Synthesis\nof Isoindolin-1-ones","volume":"84","author":"Mehta","year":"2019","journal-title":"J. Org. Chem."},{"key":"2026081708281850900_cit11","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1021\/jo802476c","article-title":"Contrasting Responses\nof Pyrido\u00ad[2,1-a]\u00adisoindol-6-ones and Their Sultam\nCounterparts to Photochemical\nActivation","volume":"74","author":"Paquette","year":"2009","journal-title":"J. Org. Chem."},{"key":"2026081708281850900_cit12","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1002\/slct.201804009","article-title":"Tin\u00ad(II)\ntriflate Catalysed Synthesis of 3-Methyleneisoindolin-1-ones","volume":"4","author":"Sharma","year":"2019","journal-title":"ChemistrySelect"},{"key":"2026081708281850900_cit13","doi-asserted-by":"publisher","first-page":"4031","DOI":"10.1016\/j.bmcl.2006.05.008","article-title":"Effect of substitution on novel tricyclic HIV-1 integrase\ninhibitors","volume":"16","author":"Fardis","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"2026081708281850900_cit14","doi-asserted-by":"publisher","first-page":"2764","DOI":"10.1021\/acs.orglett.5b01185","article-title":"Redox-Neutral\nPalladium-Catalyzed C\u2013H Functionalization\nTo Form Isoindolinones with Carboxylic Acids or Anhydrides as Readily\nAvailable Starting Materials","volume":"17","author":"Liang","year":"2015","journal-title":"Org. Lett."},{"key":"2026081708281850900_cit15","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1007\/s00706-020-02661-y","article-title":"Microwave-assisted\ngreen synthesis, antimicrobial activity,\nand drug-likeness of novel isoindolinone derivatives","volume":"151","author":"Jassem","year":"2020","journal-title":"Monatsh. Chem.\ue5f8Chem. Mon."},{"key":"2026081708281850900_cit16","doi-asserted-by":"publisher","first-page":"2870","DOI":"10.1021\/acs.joc.9b00010","article-title":"Intramolecular Arylation\nof Tertiary Enamides through Pd\u00ad(OAc)2-Catalyzed Dehydrogenative\nCross-Coupling Reaction: Construction of Fused N-Heterocyclic\nScaffolds and Synthesis of Isoindolobenzazepine Alkaloids","volume":"84","author":"Zhu","year":"2019","journal-title":"J. Org. Chem."},{"key":"2026081708281850900_cit17","doi-asserted-by":"publisher","first-page":"4603","DOI":"10.1021\/jo00302a025","article-title":"Spiroheterocycles from the reaction of nitrile oxides\nwith 3-methylenephthalimidines","volume":"55","author":"Howe","year":"1990","journal-title":"J. Org. Chem."},{"key":"2026081708281850900_cit18","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1039\/c39900000679","article-title":"Reaction of amino acids with o-acetylbenzoic\nacid","author":"Mao","year":"1990","journal-title":"J. Chem. Soc., Chem. Commun."},{"key":"2026081708281850900_cit19","doi-asserted-by":"publisher","first-page":"8444","DOI":"10.1021\/acs.orglett.9b03210","article-title":"Intramolecular\nMannich and Michael\nAnnulation Reactions of Lactam Derivatives Bearing Enals To Afford\nBicyclic N-Heterocycles","volume":"21","author":"Krishna","year":"2019","journal-title":"Org. Lett."},{"key":"2026081708281850900_cit20","doi-asserted-by":"publisher","first-page":"2675","DOI":"10.1007\/s11164-013-1378-7","article-title":"Synthesis and antimicrobial\nactivity of some isoindole derivatives","volume":"41","author":"El-Tamany","year":"2015","journal-title":"Res.\nChem. Intermed."},{"key":"2026081708281850900_cit21","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s40242-013-2294-5","article-title":"Synthesis of novel\n3-aryl isoindolinone derivatives","volume":"29","author":"Hu","year":"2013","journal-title":"Chem. Res.\nChin. Univ."},{"key":"2026081708281850900_cit22","doi-asserted-by":"publisher","first-page":"2780","DOI":"10.1021\/acs.orglett.5b01197","article-title":"Unified\nApproach to Isoindolinones and THIQs via Lewis Acid Catalyzed Domino\nMukaiyama\u2013Mannich Lactamization\/Alkylations: Application in\nthe Synthesis of (\u00b1)-Homolaudanosine","volume":"17","author":"Dhanasekaran","year":"2015","journal-title":"Org.\nLett."},{"key":"2026081708281850900_cit23","doi-asserted-by":"publisher","first-page":"8859","DOI":"10.1021\/jo901628a","article-title":"One-Pot Facile Synthesis\nof Substituted Isoindolinones via an Ugi\nFour-Component Condensation\/Diels\u2013Alder Cycloaddition\/Deselenization\u2013Aromatization\nSequence","volume":"74","author":"Huang","year":"2009","journal-title":"J. Org. Chem."},{"key":"2026081708281850900_cit24","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1016\/j.tetlet.2016.01.021","article-title":"Facile synthesis of 3-substituted\nisoindolinones","volume":"57","author":"Al-Jaroudi","year":"2016","journal-title":"Tetrahedron Lett."},{"key":"2026081708281850900_cit25","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1021\/ol9003965","article-title":"Concise Synthesis\nof Tricyclic Isoindolinones via One-Pot Cascade Multicomponent Sequences","volume":"11","author":"Medimagh","year":"2009","journal-title":"Org. Lett."},{"key":"2026081708281850900_cit26","doi-asserted-by":"publisher","first-page":"5357","DOI":"10.1002\/ejoc.201200678","article-title":"Synthesis and Reactivity of the 3-Substituted\nIsoindolinone Framework to Assemble Highly Functionalized Related\nStructures","author":"Petronzi","year":"2012","journal-title":"Eur. J. Org. Chem."},{"key":"2026081708281850900_cit27","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1016\/j.tetlet.2014.01.154","article-title":"(\u00b1)-CSA catalyzed one-pot synthesis\nof 6,7-dihydrospiro\u00ad[indole-3,1\u2032-isoindoline]-2,3\u2032,4\u00ad(1H,5H)-trione\nderivatives: easy access of spirooxindoles and ibophyllidine-like\nalkaloids","volume":"55","author":"Srivastava","year":"2014","journal-title":"Tetrahedron Lett."},{"key":"2026081708281850900_cit28","doi-asserted-by":"publisher","first-page":"2881","DOI":"10.1002\/adsc.201000602","article-title":"One-Pot Hydroxy Group Activation\/Carbon-Carbon\nBond Forming Sequence\nUsing a Br\u00f8nsted Base\/Br\u00f8nsted Acid System","volume":"352","author":"Devineau","year":"2010","journal-title":"Adv. Synth. Catal."},{"key":"2026081708281850900_cit29","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1177\/174751989902300803","article-title":"Palladium-catalysed Heteroannulation\nwith Acetylenic Carbinols: Synthesis of 3-Acylmethylisoindolin-1-ones","volume":"23","author":"Kundu","year":"1999","journal-title":"J. Chem. Res., Synop."},{"key":"2026081708281850900_cit30","doi-asserted-by":"publisher","first-page":"9192","DOI":"10.1016\/j.tet.2012.08.095","article-title":"Rhodium catalyzed\nsynthesis of isoindolinones via C\u2013H\nactivation ofN-benzoylsulfonamides","volume":"68","author":"Zhu","year":"2012","journal-title":"Tetrahedron"},{"key":"2026081708281850900_cit31","doi-asserted-by":"publisher","first-page":"2102","DOI":"10.1021\/acs.orglett.5b00676","article-title":"An Efficient Entry tosyn- and anti-Selective Isoindolinones via an Organocatalytic\nDirect\nMannich\/Lactamization Sequence","volume":"17","author":"Bisai","year":"2015","journal-title":"Org. Lett."},{"key":"2026081708281850900_cit32","doi-asserted-by":"publisher","first-page":"2494","DOI":"10.1021\/acscatal.7b00031","article-title":"Ruthenium-Catalyzed\nRedox-Neutral [4 + 1] Annulation of Benzamides and Propargyl Alcohols\nvia C\u2013H Bond Activation","volume":"7","author":"Wu","year":"2017","journal-title":"ACS Catal."},{"key":"2026081708281850900_cit33","doi-asserted-by":"publisher","first-page":"2519","DOI":"10.1039\/c6nj03813a","article-title":"An efficient approach to 3-oxoisoindoline-1-difluoroalkyl\nderivatives\nvia a metal triflate-catalyzed Mannich\/lactamization cascade reaction","volume":"41","author":"Chen","year":"2017","journal-title":"New J. Chem."},{"key":"2026081708281850900_cit34","doi-asserted-by":"publisher","first-page":"16416","DOI":"10.1021\/ja052200m","article-title":"A Green\nChemistry Approach to a More Efficient Asymmetric\nCatalyst: Solvent-Free and Highly Concentrated Alkyl Additions to\nKetones","volume":"127","author":"Jeon","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"2026081708281850900_cit35","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1039\/c3gc40162f","article-title":"An eco-benign and highly efficient\naccess to 3-heterocyclic-substituted isoindolinones in ammonia water","volume":"15","author":"Shen","year":"2013","journal-title":"Green Chem."},{"key":"2026081708281850900_cit36","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1039\/b716534j","article-title":"Aqueous microwave\nchemistry: a clean and green synthetic\ntool for rapid drug discovery","volume":"37","author":"Polshettiwar","year":"2008","journal-title":"Chem. Soc. Rev."},{"key":"2026081708281850900_cit37","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1007\/s00044-020-02546-z","article-title":"Microwave-assisted\nsynthesis, molecular docking and anti-HIV activities of some drug-like\nquinolone derivatives","volume":"29","author":"Jassem","year":"2020","journal-title":"Med. Chem. Res."},{"key":"2026081708281850900_cit38","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1039\/b924111f","article-title":"Solvent-free microwave-assisted Meyers\u2019\nlactamization","volume":"12","author":"Jida","year":"2010","journal-title":"Green Chem."},{"key":"2026081708281850900_cit39","doi-asserted-by":"publisher","first-page":"5109","DOI":"10.1016\/j.tetlet.2010.07.021","article-title":"Synthesis\nof five- and six-membered lactams via solvent-free microwave Ugi reaction","volume":"51","author":"Jida","year":"2010","journal-title":"Tetrahedron Lett."},{"key":"2026081708281850900_cit40","doi-asserted-by":"publisher","first-page":"4936","DOI":"10.3390\/molecules14124936","article-title":"Microwave\nMulticomponent Synthesis","volume":"14","author":"Hu\u0308gel","year":"2009","journal-title":"Molecules"},{"key":"2026081708281850900_cit41","doi-asserted-by":"publisher","first-page":"357","DOI":"10.2174\/138527210790231892","article-title":"Microwave-Assisted\nMulticomponent Reactions in the\nHeterocyclic Chemistry","volume":"14","author":"Jiang","year":"2010","journal-title":"Curr. Org. Chem."},{"key":"2026081708281850900_cit42","doi-asserted-by":"publisher","first-page":"2562","DOI":"10.1134\/s1070363219120363","article-title":"Application of the\nCleavable Isocyanide in Efficient Approach to Pyroglutamic Acid Analogues\nwith Potential Biological Activity","volume":"89","author":"Jassem","year":"2019","journal-title":"Russ. J.\nGen. Chem."},{"key":"2026081708281850900_cit43a","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1080\/10406638.2020.1809468","article-title":"An Efficient Synthesis of Phthalimides\nand Their Biological Activities","volume":"42","author":"Jelali","year":"2022","journal-title":"Polycyclic\nAromat. Compd."},{"key":"2026081708281850900_cit43b","article-title":"Synthesis and\nCharacterization of 3-Methylene Isoindolinones by Two Synthetic Routes","volume-title":"Polycyclic Aromatic Compounds","author":"Jelali","year":"2021"},{"key":"2026081708281850900_cit43c","doi-asserted-by":"publisher","first-page":"6577185","DOI":"10.1155\/2022\/6577185","article-title":"Copper-Catalyzed Hydroboration of Enamides with Bis\u00ad(pinacolato)\u00addiboron:\nPromising Agents with Antimicrobial Activities","volume":"Volume 2022","author":"Jelali","year":"2022","journal-title":"J. Chem."},{"key":"2026081708281850900_cit44a","doi-asserted-by":"publisher","first-page":"4613","DOI":"10.1021\/jm00102a016","article-title":"Novel Spirosuccinimides with Incorporated\nIsoindolone and Benzisothiazole 1,1-Dioxide Moieties as Aldose Reductase\nInhibitors and Antihyperglycemic Agents","volume":"35","author":"Wrobel","year":"1992","journal-title":"J.\nMed. Chem."},{"key":"2026081708281850900_cit44b","doi-asserted-by":"publisher","first-page":"7707","DOI":"10.1016\/0040-4039(96)01738-8","article-title":"Benzothienoindolizidines via intramolecular\naryl radical cyclization or palladium catalyzed cyclization","volume":"37","author":"Pigeon","year":"1996","journal-title":"Tetrahedron Lett."},{"key":"2026081708281850900_cit44c","doi-asserted-by":"publisher","first-page":"10313","DOI":"10.1016\/s0040-4020(97)00680-7","article-title":"An efficient one-pot synthesis of 3-(aryl and alkyl)\u00admethylene-1H-isoindolin-1-ones via aryne cyclization\nand Horner reaction of o-(and m-)\u00adhalogeno-N-phosphorylmethylbenzamide derivatives","volume":"53","author":"Couture","year":"1997","journal-title":"Tetrahedron"},{"key":"2026081708281850900_cit44d","doi-asserted-by":"publisher","first-page":"3128","DOI":"10.1021\/jo972247t","article-title":"Total Syntheses of Taliscanine, Velutinam, and Enterocarpam\nII","volume":"63","author":"Couture","year":"1998","journal-title":"J. Org. Chem."},{"key":"2026081708281850900_cit44e","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1016\/s0960-894x(98)00252-2","article-title":"Isoindolinone enantiomers having\naffinity for the dopamine D4receptor","volume":"8","author":"Belliotti","year":"1998","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"2026081708281850900_cit45","doi-asserted-by":"publisher","first-page":"9705","DOI":"10.1038\/srep09705","article-title":"Structure-based\ndiscovery of the first non-covalent inhibitors of Leishmania major\ntryparedoxin peroxidase by high throughput docking","volume":"5","author":"Brindisi","year":"2015","journal-title":"Sci. Rep."},{"key":"2026081708281850900_cit46","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1080\/14756366.2017.1316494","article-title":"Synthesis and biological evaluation of anti-Toxoplasma\ngondii activity of a novel scaffold of thiazolidinone derivatives","volume":"32","author":"Carradori","year":"2017","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"2026081708281850900_cit47","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201900597","article-title":"New Antiparasitic Bis-Naphthoquinone\nDerivatives","volume":"17","author":"Jentzsch","year":"2020","journal-title":"Chem. Biodiversity"},{"key":"2026081708281850900_cit48","unstructured":"Molecular Operating Environment (MOE),\nversion 2022.02; Chemical Computing Group ULC: Montreal,\nCanada, 2023, http:\/\/www.chemcomp.com."},{"key":"2026081708281850900_cit49","unstructured":"http:\/\/www.rcsb.org (accessed\n1998)."}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.3c02362","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/8\/25\/23067\/4401767\/ao3c02362.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/8\/25\/23067\/4401767\/ao3c02362.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:38:40Z","timestamp":1786970320000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/acsodf\/article\/8\/25\/23067\/407558\/Copper-Catalyzed-Asymmetric-Hydroboration-Reaction"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,9]]},"references-count":64,"journal-issue":{"issue":"25","published-online":{"date-parts":[[2023,6,9]]},"published-print":{"date-parts":[[2023,6,27]]}},"URL":"https:\/\/doi.org\/10.1021\/acsomega.3c02362","relation":{},"ISSN":["2470-1343"],"issn-type":[{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,9]]}}}