{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:57:57Z","timestamp":1792623477172,"version":"4.5.0"},"reference-count":91,"publisher":"American Chemical Society (ACS)","issue":"46","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T?rkiye Bilimsel ve Teknolojik Arastirma Kurumu","doi-asserted-by":"publisher","award":["119M578"],"award-info":[{"award-number":["119M578"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"T?rkiye Bilimsel ve Teknolojik Arastirma Kurumu","doi-asserted-by":"publisher","award":["2210-C"],"award-info":[{"award-number":["2210-C"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"T?rkiye Bilimsel ve Teknolojik Arastirma Kurumu","doi-asserted-by":"publisher","award":["2210-A"],"award-info":[{"award-number":["2210-A"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"T?rkiye Bilimsel ve Teknolojik Arastirma Kurumu","doi-asserted-by":"publisher","award":["2211-A"],"award-info":[{"award-number":["2211-A"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2023,11,21]]},"DOI":"10.1021\/acsomega.3c06448","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T18:55:23Z","timestamp":1699469723000},"page":"44148-44162","source":"Crossref","is-referenced-by-count":4,"title":["Comprehensive Transcriptomic Investigation of Rett Syndrome Reveals Increasing Complexity Trends from Induced Pluripotent Stem Cells to Neurons with Implications for Enriched Pathways"],"prefix":"10.1021","volume":"8","author":[{"given":"Yusuf Caglar","family":"Odabasi","sequence":"first","affiliation":[{"name":"Department of Bioengineering, Faculty of Engineering, Ege University, Izmir 35100, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5685-3737","authenticated-orcid":true,"given":"Sena","family":"Yanasik","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Faculty of Engineering, Ege University, Izmir 35100, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pelin","family":"Saglam-Metiner","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Faculty of Engineering, Ege University, Izmir 35100, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasin","family":"Kaymaz","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Faculty of Engineering, Ege University, Izmir 35100, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4509-2212","authenticated-orcid":true,"given":"Ozlem","family":"Yesil-Celiktas","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Faculty of Engineering, Ege University, Izmir 35100, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,11,8]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2021.22"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1111\/cdep.12319"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01662-7"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.01.011"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.3414"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1007\/BF02206866"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.3258"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30217-9"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.7b00346"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2012.156"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1159\/000345845"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2012.01861.x"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.698812"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-019-09793-5"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2019.146644"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.590119"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.610427"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1080\/15622975.2019.1593501"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22189954"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911125"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-559"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbw139"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2018.04.001"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.02.107"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-020-0527-2"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2022.924155"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.10.1"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.06.025"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2014.00160"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01369"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23179707"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2019.01.005"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2121-13-19"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.07.099"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-021-00906-5"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.1985"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20163925"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00416"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.685646"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.61"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1159\/000362891"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1080\/13816810802626399"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2006.02.011"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1177\/1759091416689020"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.5606\/ArchRheumatol.2019.7100"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.52711\/0974-360X.2021.00896"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/195935"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1172\/JCI137221"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0086-18.2018"},{"key":"ref52\/cit52","unstructured":"Zhao, L.; Wang, X.; Yang, J.; Jiang, Q.; Zhang, J.; Wu, F. MECP2 promotes the migration and invasion of gastric cancer cells by modulating the Notch1\/c-Myc\/mTOR signaling pathways by suppressing FBXW7 transcription Am. J. Cancer Res. 2022, 12, 5183\u20135204."},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2018.05.001"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2021.108805"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109124"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhz085"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.7696"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.258465"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.01.004"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-5-47"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-95630-2"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11090848"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq265"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0281-9"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.86"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e11-09-0784"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00125"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-45635-9"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21020518"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00077"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1038\/srep38435"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0116-9"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2016.42"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.608125"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201910270"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16907-0"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M105747200"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1093\/bfgp\/elw023"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2021.108768"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-90517-8"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00278"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.590009"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1618210114"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202012433"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.7563.1"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3519"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.97"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts034"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.3c06448","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.3c06448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T12:01:49Z","timestamp":1700568109000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.3c06448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,8]]},"references-count":91,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2023,11,21]]}},"alternative-id":["10.1021\/acsomega.3c06448"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.3c06448","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"value":"2470-1343","type":"print"},{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,8]]}}}