{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:45:15Z","timestamp":1778892315409,"version":"3.51.4"},"reference-count":75,"publisher":"American Chemical Society (ACS)","issue":"44","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRK2158"],"award-info":[{"award-number":["GRK2158"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003163","name":"Forschungszentrum J\u00fclich","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003163","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003484","name":"Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2023,11,7]]},"DOI":"10.1021\/acsomega.3c06503","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T14:32:05Z","timestamp":1698417125000},"page":"41816-41834","source":"Crossref","is-referenced-by-count":9,"title":["Modular Approach for the Synthesis and Bioactivity Profiling of 8,8\u2032-Biflavones"],"prefix":"10.1021","volume":"8","author":[{"given":"Moritz K. T.","family":"Klischan","sequence":"first","affiliation":[{"name":"Institute of Bioorganic Chemistry, Heinrich Heine University D\u00fcsseldorf, Forschungszentrum J\u00fclich, Stetternicher Forst, Geb.15.8, 52426 J\u00fclich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1429-230X","authenticated-orcid":true,"given":"Flaminia","family":"Mazzone","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hospital Hygiene, Medical Faculty and University Hospital D\u00fcsseldorf, Heinrich Heine University D\u00fcsseldorf, Universit\u00e4tsstr. 1, 40225 D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Berning","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine I, Medical Faculty and University Hospital D\u00fcsseldorf, Heinrich Heine University D\u00fcsseldorf, Universit\u00e4tsstr. 1, 40225 D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Greb","sequence":"additional","affiliation":[{"name":"Institute of Bioorganic Chemistry, Heinrich Heine University D\u00fcsseldorf, Forschungszentrum J\u00fclich, Stetternicher Forst, Geb.15.8, 52426 J\u00fclich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Schlamkow","sequence":"additional","affiliation":[{"name":"Institute of Bioorganic Chemistry, Heinrich Heine University D\u00fcsseldorf, Forschungszentrum J\u00fclich, Stetternicher Forst, Geb.15.8, 52426 J\u00fclich, Germany"},{"name":"Institut f\u00fcr Bio- und Geowissenschaften (IBG-1: Bioorganische Chemie) Forschungszentrum, 52428 J\u00fclich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona","family":"Haase","sequence":"additional","affiliation":[{"name":"Institute of Bioorganic Chemistry, Heinrich Heine University D\u00fcsseldorf, Forschungszentrum J\u00fclich, Stetternicher Forst, Geb.15.8, 52426 J\u00fclich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Frey","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry, University of Stuttgart, 70569 Stuttgart, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4167-7806","authenticated-orcid":true,"given":"Bj\u00f6rn","family":"Stork","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine I, Medical Faculty and University Hospital D\u00fcsseldorf, Heinrich Heine University D\u00fcsseldorf, Universit\u00e4tsstr. 1, 40225 D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Pfeffer","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hospital Hygiene, Medical Faculty and University Hospital D\u00fcsseldorf, Heinrich Heine University D\u00fcsseldorf, Universit\u00e4tsstr. 1, 40225 D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9819-889X","authenticated-orcid":true,"given":"J\u00f6rg","family":"Pietruszka","sequence":"additional","affiliation":[{"name":"Institute of Bioorganic Chemistry, Heinrich Heine University D\u00fcsseldorf, Forschungszentrum J\u00fclich, Stetternicher Forst, Geb.15.8, 52426 J\u00fclich, Germany"},{"name":"Institut f\u00fcr Bio- und Geowissenschaften (IBG-1: Bioorganische Chemie) Forschungszentrum, 52428 J\u00fclich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2023,10,27]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)83325-1"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)92970-9"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)75610-3"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4039(64)83077-X"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)85693-9"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2005.07.091"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22020299"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-001-1151-3"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1055\/s-1999-13971"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2020.111642"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2009.03.003"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.2174\/1389557517666161104130026"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.4.1352-1364.2006"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21417"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.09.005"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2010.03.024"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1383211"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.04.106"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/np4010739"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.2174\/0929867322666150716115300"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200800035"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/ol2018449"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2019.05.020"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5b00829"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/ar700155p"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01409"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.07.013"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)97549-5"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4020(76)80071-3"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/jo970670w"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(96)02475-6"},{"key":"ref32\/cit32","first-page":"227","volume":"23","author":"Parthasarathy M.","year":"1984","journal-title":"Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem."},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201500798"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.19970150513"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200462661"},{"key":"ref36\/cit36","first-page":"1","volume-title":"Progress in the Chemistry of Organic Natural Products","volume":"82","author":"Bringmann G.","year":"2001"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b02535"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2173"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1071\/CH9862177"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.200600899"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/ol990758r"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.200790205"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1039\/C3NP70090A"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.3184\/174751912X13285269293913"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/np1005604"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.08.035"},{"key":"ref47\/cit47","first-page":"183","volume":"6","author":"Dianin A.","year":"1874","journal-title":"Zh. Russ. Fiz.-Khim. O-va."},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1080\/00268949008036026"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/jo00399a057"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/jo01292a051"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200390216"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-41027"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b03890"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b06494"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.8b02083"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1021\/ja500183z"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b05898"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.8b03084"},{"key":"ref59\/cit59","volume-title":"Design and Analysis of Experiments","author":"Montgomery D. C.","year":"2017"},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/B978-012369542-0\/50005-2","volume-title":"Toxoplasma Gondii","author":"Dard\u00e9 M.","year":"2007"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090203"},{"key":"ref62\/cit62","unstructured":"EFSA, E. 2019; p e05926."},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(98)00315-3"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.2174\/1568026615666141209144506"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2005.10.005"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2017.01.049"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.03.002"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27061781"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2010.04.001"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2007.03.031"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1039\/D1OB01802G"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201701009"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(03)00752-2"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2014.04.022"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1021\/jo3018473"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.3c06503","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.3c06503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:44:25Z","timestamp":1699364665000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.3c06503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,27]]},"references-count":75,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2023,11,7]]}},"alternative-id":["10.1021\/acsomega.3c06503"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.3c06503","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"value":"2470-1343","type":"print"},{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,27]]}}}