{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:25:17Z","timestamp":1791393917729,"version":"4.3.3"},"reference-count":83,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Alzheimer\u2019s disease (AD) is a neurodegenerative disorder characterized by progressive and irreversible impairment of memory and other cognitive functions of the aging brain. Pathways such as amyloid beta neurotoxicity, tau pathogenesis and neuroinflammatory have been used to understand AD, despite not knowing the definite molecular mechanism which causes this progressive disease. This review attempts to summarize the small molecules that target these pathways using various techniques involving high-throughput screening, molecular modeling, custom bioassays, and spectroscopic detection tools. Novel and evolving screening methods developed to advance drug discovery initiatives in AD research are also highlighted.<\/jats:p>","DOI":"10.1021\/acsomega.3c07046","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T01:04:56Z","timestamp":1707095096000},"page":"6059-6073","source":"Crossref","is-referenced-by-count":23,"title":["Screening Techniques\nfor Drug Discovery in Alzheimer\u2019s\nDisease"],"prefix":"10.1021","volume":"9","author":[{"given":"Sandra","family":"Maniam","sequence":"first","affiliation":[{"name":"Universiti Putra Malaysia , , , ,","place":["Serdang, Selangor Darul Ehsan, Malaysia, 43400 UPM"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0272-864X","authenticated-orcid":true,"given":"Subashani","family":"Maniam","sequence":"additional","affiliation":[{"name":"RMIT University , , , ,","place":["Melbourne, Victoria, Australia, 3001"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"issue":"5800","key":"2026081709180530400_cit1","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1126\/science.1132814","article-title":"A Century of Alzheimer\u2019s Disease","volume":"314","author":"Goedert","year":"2006","journal-title":"Science"},{"issue":"11","key":"2026081709180530400_cit2","doi-asserted-by":"publisher","first-page":"4051","DOI":"10.1073\/pnas.85.11.4051","article-title":"Cloning and\nsequencing of the cDNA encoding a core protein of the paired helical\nfilament of Alzheimer disease: identification as the microtubule-associated\nprotein tau","volume":"85","author":"Goedert","year":"1988","journal-title":"Proc. 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