{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:53:31Z","timestamp":1786978411873,"version":"build-2736575974"},"reference-count":42,"publisher":"American Chemical Society (ACS)","issue":"25","license":[{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515140046"],"award-info":[{"award-number":["2022A1515140046"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515010720"],"award-info":[{"award-number":["2023A1515010720"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Drug Administration of Guangdong Province","award":["2022TDB37"],"award-info":[{"award-number":["2022TDB37"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Liriodendron chinense has been widely utilized in traditional Chinese medicine to treat dispelling wind and dampness and used for alleviating cough and diminishing inflammation. However, the antioxidant, antimicrobial, and anti-inflammatory effects of L. chinense leaves and the key active constituents remained elusive. So, we conducted some experiments to support the application of L. chinense in traditional Chinese medicine by investigating the antioxidant, antibacterial, and anti-inflammatory abilities, and to identify the potential key constituents responsible for the activities. The ethanol extract of L. chinense leaves (LCLE) was isolated and extracted, and assays measuring ferric reducing antioxidant power, total reducing power, DPPH\u2022, ABTS\u2022+, and \u2022OH were used to assess its in vitro antioxidant capacities. Antimicrobial activities of LCLE were investigated by minimal inhibitory levels, minimum antibacterial concentrations, disc diffusion test, and scanning electron microscope examination. Further, in vivo experiments including macro indicators examination, histopathological examination, and biochemical parameters measurement were conducted to investigate the effects of LCLE on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. LCLE was further isolated and purified through column chromatography, and LPS-induced RAW264.7 cells were constructed to assess the diminished inflammation potential of the identified chemical composites. ABTS\u2022+ and \u2022OH radicals were extensively neutralized by the LCLE treatment. LCLE administration also presented broad-spectrum antimicrobial properties, especially against Staphylococcus epidermidis by disrupting cell walls. LPS-induced ALI in mice was significantly ameliorated by LCLE intervention, as evidenced by the histological changes in the lung and liver tissues as well as the reductions of nitric oxide (NO), TNF-\u03b1, and IL-6 production. Furthermore, three novel compounds including fragransin B2, liriodendritol, and rhamnocitrin were isolated, purified, and identified from LCLE. These three compounds exhibited differential regulation on NO accumulation and IL-10, IL-1\u03b2, IL-6, TNF-\u03b1, COX-2, and iNOS mRNA expression in RAW264.7 cells induced by LPS. Fragransin B2 was more effective in inhibiting TNF-\u03b1 mRNA expression, while rhamnocitrin was more powerful in inhibiting IL-6 mRNA expression. LCLE had significant antioxidant, antimicrobial, and anti-inflammatory effects. Fragransin B2, liriodendritol, and rhamnocitrin were probably key active constituents of LCLE, which might act synergistically to treat inflammatory-related disorders. This study provided a valuable view of the healing potential of L. chinense leaves in curing inflammatory diseases.<\/jats:p>","DOI":"10.1021\/acsomega.3c10269","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T12:28:09Z","timestamp":1718022489000},"page":"27002-27016","source":"Crossref","is-referenced-by-count":4,"title":["Antioxidant, Antimicrobial,\nand Anti-Inflammatory\nEffects of\n                    <i>Liriodendron chinense<\/i>\n                    Leaves"],"prefix":"10.1021","volume":"9","author":[{"given":"Ya-Li","family":"Wang","sequence":"first","affiliation":[{"name":"Southern Medical University , , ,","place":["Guangzhou, China, 510515"]},{"name":"Southern Medical University , , ,","place":["Guangzhou, China, 510515"]},{"name":"Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases , ,","place":["Guangzhou, China, 510515"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Ni","sequence":"additional","affiliation":[{"name":"Southern Medical University , , ,","place":["Guangzhou, China, 510515"]},{"name":"Southern Medical University , , ,","place":["Guangzhou, China, 510515"]},{"name":"Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases , ,","place":["Guangzhou, China, 510515"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Hao","family":"Zeng","sequence":"additional","affiliation":[{"name":"Southern Medical University , , ,","place":["Guangzhou, China, 510515"]},{"name":"Southern Medical University , , ,","place":["Guangzhou, China, 510515"]},{"name":"Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases , ,","place":["Guangzhou, China, 510515"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Feng","sequence":"additional","affiliation":[{"name":"Southern Medical University , , ,","place":["Guangzhou, China, 510515"]},{"name":"Southern Medical University , , ,","place":["Guangzhou, China, 510515"]},{"name":"Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases , ,","place":["Guangzhou, China, 510515"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Feng","family":"Cai","sequence":"additional","affiliation":[{"name":"Southern Medical University , , ,","place":["Guangzhou, China, 510515"]},{"name":"Southern Medical University , , ,","place":["Guangzhou, China, 510515"]},{"name":"Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases , ,","place":["Guangzhou, China, 510515"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Cong","family":"Chen","sequence":"additional","affiliation":[{"name":"Southern Medical University , , ,","place":["Guangzhou, China, 510515"]},{"name":"Southern Medical University , , ,","place":["Guangzhou, China, 510515"]},{"name":"Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases , ,","place":["Guangzhou, China, 510515"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song-Xia","family":"Lin","sequence":"additional","affiliation":[{"name":"Southern Medical University , , ,","place":["Guangzhou, China, 510515"]},{"name":"Southern Medical University , , ,","place":["Guangzhou, China, 510515"]},{"name":"Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases , ,","place":["Guangzhou, China, 510515"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9694-5399","authenticated-orcid":true,"given":"Cui-Ping","family":"Jiang","sequence":"additional","affiliation":[{"name":"Southern Medical University , , ,","place":["Guangzhou, China, 510515"]},{"name":"Southern Medical University , , ,","place":["Guangzhou, China, 510515"]},{"name":"Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases , ,","place":["Guangzhou, China, 510515"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Kui","family":"Yi","sequence":"additional","affiliation":[{"name":"Southern Medical University , , ,","place":["Guangzhou, China, 510515"]},{"name":"Southern Medical University , , ,","place":["Guangzhou, China, 510515"]},{"name":"Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases , ,","place":["Guangzhou, China, 510515"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Shen","sequence":"additional","affiliation":[{"name":"Southern Medical University , , ,","place":["Guangzhou, China, 510515"]},{"name":"Southern Medical University , , ,","place":["Guangzhou, China, 510515"]},{"name":"Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases , ,","place":["Guangzhou, China, 510515"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4370-2147","authenticated-orcid":true,"given":"Chun-Yan","family":"Shen","sequence":"additional","affiliation":[{"name":"Southern Medical University , , ,","place":["Guangzhou, China, 510515"]},{"name":"Southern Medical University , , ,","place":["Guangzhou, China, 510515"]},{"name":"Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases , ,","place":["Guangzhou, China, 510515"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,6,10]]},"reference":[{"key":"2026081709085132700_cit1","doi-asserted-by":"publisher","first-page":"30048","DOI":"10.1021\/acsomega.3c02033","article-title":"Molecular insights into the in vivo analgesic and anti-inflammatory activity of indomethacin\nAnalogues","volume":"8","author":"Ahmad","year":"2023","journal-title":"ACS Omega"},{"key":"2026081709085132700_cit2","doi-asserted-by":"publisher","first-page":"37971","DOI":"10.1021\/acsomega.3c03480","article-title":"Modulation of MAPK\/NF-\u03baB\npathway\nand NLRP3 inflammasome by secondary metabolites from red Algae: A\nmechanistic study","volume":"8","author":"Nabil-Adam","year":"2023","journal-title":"ACS Omega"},{"key":"2026081709085132700_cit3","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26196073","article-title":"Cissus\nsubtetragona\nPlanch. ameliorates inflammatory responses in LPS-induced macrophages,\nHCl\/EtOH-induced gastritis, and LPS-induced lung injury via attenuation\nof Src and TAK1","volume":"26","author":"Rahmawati","year":"2021","journal-title":"Molecules"},{"key":"2026081709085132700_cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115086","article-title":"Anti-inflammatory effect of flavonoids\nfrom chestnut\nflowers in lipopolysaccharide-stimulated RAW 264.7 macrophages and\nacute lung injury in mice","volume":"290","author":"Peng","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"2026081709085132700_cit5","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.jff.2017.05.055","article-title":"Structural\ncharacterization and immunomodulatory activity of novel polysaccharides\nfrom Citrus aurantium Linn. variant amara Engl","volume":"35","author":"Shen","year":"2017","journal-title":"J. Funct. Foods"},{"key":"2026081709085132700_cit6","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.jff.2017.03.060","article-title":"Immune-enhancing\nactivity of polysaccharides\nfrom Hibiscus sabdariffa Linn. via MAPK and NF-kB signaling pathways\nin RAW264.7 cells","volume":"34","author":"Shen","year":"2017","journal-title":"J. Funct. 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Ethnopharmacol."},{"key":"2026081709085132700_cit14","doi-asserted-by":"publisher","first-page":"4234","DOI":"10.3390\/molecules19044234","article-title":"Antioxidant and\nanticancer constituents from the leaves of Liriodendron tulipifera","volume":"19","author":"Kang","year":"2014","journal-title":"Molecules"},{"key":"2026081709085132700_cit15","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1039\/D2FO03003A","article-title":"p-Synephrine\nameliorates alloxan-induced diabetes mellitus through inhibiting oxidative\nstress and inflammation via suppressing the NF-kappa B and MAPK pathways","volume":"14","author":"Wang","year":"2023","journal-title":"Food Funct."},{"key":"2026081709085132700_cit16","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.809482","article-title":"Chemical antioxidant quality markers\nof Chrysanthemum morifolium using a spectrum-effect approach","volume":"13","author":"Lu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"2026081709085132700_cit17","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25040967","article-title":"Chemical\ncomposition, algicidal, antimicrobial, and antioxidant activities\nof the essential oils of Taiwania flousiana Gaussen","volume":"25","author":"Liu","year":"2020","journal-title":"Molecules"},{"key":"2026081709085132700_cit18","doi-asserted-by":"publisher","first-page":"2479","DOI":"10.1016\/j.fct.2009.07.005","article-title":"Studies on the antioxidant activity\nof essential oil and different\nsolvent extracts of Vitex agnus castus L. fruits from Turkey","volume":"47","author":"Sarikurkcu","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"2026081709085132700_cit19","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.foodchem.2014.11.009","article-title":"A universally\ncalibrated microplate ferric reducing antioxidant power (FRAP) assay\nfor foods and applications to Manuka honey","volume":"174","author":"de\nla Torre","year":"2015","journal-title":"Food Chem."},{"key":"2026081709085132700_cit20","doi-asserted-by":"publisher","DOI":"10.3390\/plants12081587","article-title":"Antibiotic-potentiating\nactivity of the Schinus terebinthifolius Raddi essential oil against\nMDR bacterial Strains","volume":"12","author":"da\nSilva","year":"2023","journal-title":"Plants"},{"key":"2026081709085132700_cit21","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.lwt.2016.04.020","article-title":"Biocontrol of postharvest fungal decay of tomatoes\nwith a combination of thymol and salicylic acid screening from 11\nnatural agents","volume":"72","author":"Kong","year":"2016","journal-title":"LWT--Food Sci. 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Ethnopharmacol."},{"key":"2026081709085132700_cit24","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25122825","article-title":"Lignans, amides, and saponins from\nHaplophyllum tuberculatum\nand their antiprotozoal activity","volume":"25","author":"Mahmoud","year":"2020","journal-title":"Molecules"},{"key":"2026081709085132700_cit25","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/S1674-6384(15)60051-X","article-title":"Immunological\nactivities of components\nfrom leaves of Liriodendron chinensis","volume":"7","author":"Yang","year":"2015","journal-title":"Chin.\nHerb. Med."},{"key":"2026081709085132700_cit26","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1080\/14786419.2012.678350","article-title":"A new flavonol\nfrom Oxytropis ochrocephala Bunge","volume":"27","author":"Li","year":"2013","journal-title":"Nat. Prod.\nRes."},{"key":"2026081709085132700_cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2022.115447","article-title":"Non-food bioactive forest product\nliriodenine: Sources, chemistry, and bioactivities","volume":"187","author":"Huang","year":"2022","journal-title":"Ind. Crops Prod."},{"key":"2026081709085132700_cit28","doi-asserted-by":"publisher","first-page":"30485","DOI":"10.1007\/s11356-019-06217-4","article-title":"Exploring\nnew applications\nof tulip tree (Liriodendron tulipifera L.): leaf essential oil as\napoptotic agent for human glioblastoma","volume":"26","author":"Quassinti","year":"2019","journal-title":"Environ.\nSci. Pollut. Res."},{"key":"2026081709085132700_cit29","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-021-02745-1","article-title":"Panaxydol attenuates ferroptosis\nagainst LPS-induced acute lung injury\nin mice by Keap1-Nrf2\/HO-1 pathway","volume":"19","author":"Li","year":"2021","journal-title":"J. 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Inflammation Res."},{"issue":"1","key":"2026081709085132700_cit33","doi-asserted-by":"publisher","DOI":"10.3390\/pr8010117","article-title":"Correlation\nbetween antibacterial activity and free-radical scavenging: In-vitro evaluation of polar\/non-polar extracts from 25\nplants","volume":"8","author":"Rayan","year":"2020","journal-title":"Processes"},{"key":"2026081709085132700_cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116981","article-title":"In vitro anti-bacterial activity and\nits preliminary mechanism of action of the non-medicinal parts of\nSanguisorba officinalis L. against Helicobacter pylori infection","volume":"318","author":"Chen","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"2026081709085132700_cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116892","article-title":"Curcusinol from the fruit of Carex\nbaccans with antibacterial activity against multidrug-resistant strains","volume":"318","author":"Liu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"2026081709085132700_cit36","doi-asserted-by":"publisher","DOI":"10.3390\/foods12010086","article-title":"Phenolic\nprofile and the antioxidant, anti-inflammatory, and antimicrobial\nproperties of Acai (Euterpe oleracea) Meal: A prospective study","volume":"12","author":"de\nSouza Silva","year":"2022","journal-title":"Foods"},{"key":"2026081709085132700_cit37","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.bmc.2016.11.055","article-title":"Structure-activity\nrelationship of the inhibitory effects of flavonoids on nitric oxide\nproduction in RAW264.7 cells","volume":"25","author":"Jiang","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"2026081709085132700_cit38","doi-asserted-by":"publisher","DOI":"10.29219\/fnr.v67.9383","article-title":"Chukrasia tabularis limonoid plays\nanti-inflammatory role by regulating NF-\u03baB signaling pathway\nin lipopolysaccharide-induced macrophages","volume":"67","author":"Shen","year":"2023","journal-title":"Food\nNutr. Res."},{"key":"2026081709085132700_cit39","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28155731","article-title":"Triterpenoid and coumarin isolated from astilbe grandis with anti-Inflammatory\neffects through inhibiting the NF-\u03baB Pathway in LPS-induced\nRAW264.7 Cells","volume":"28","author":"Luo","year":"2023","journal-title":"Molecules"},{"key":"2026081709085132700_cit40","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.916102","article-title":"Aqueous extract of descuraniae\nsemen attenuates lipopolysaccharide-induced inflammation and apoptosis\nby regulating the proteasomal degradation and IRE1a-dependent unfolded\nprotein response in A549 cells","volume":"13","author":"Hsieh","year":"2022","journal-title":"Front. Immunol."},{"key":"2026081709085132700_cit41","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-021-02745-1","article-title":"Panaxydol attenuates\nferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2\/HO-1\npathway","volume":"19","author":"Li","year":"2021","journal-title":"J. Transl. 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