{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:09:58Z","timestamp":1791810598309,"version":"4.3.4"},"reference-count":56,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008770","name":"Anadolu ?niversitesi","doi-asserted-by":"publisher","award":["2105S074"],"award-info":[{"award-number":["2105S074"]}],"id":[{"id":"10.13039\/501100008770","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2024,3,12]]},"DOI":"10.1021\/acsomega.4c00026","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T16:07:30Z","timestamp":1709136450000},"page":"12175-12183","source":"Crossref","is-referenced-by-count":47,"title":["Design, Synthesis, and\n                    <i>In Vivo<\/i>\n                    Evaluation of a New Series of Indole-Chalcone Hybrids as Analgesic and Anti-Inflammatory Agents"],"prefix":"10.1021","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5484-3818","authenticated-orcid":true,"given":"Iman","family":"Baramaki","sequence":"first","affiliation":[{"name":"Laboratory of Neurotherapeutics, Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, 00014 Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8159-663X","authenticated-orcid":true,"given":"Mehlika Dilek","family":"Alt\u0131ntop","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eski\u015fehir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, Anadolu University, 26470 Eski\u015fehir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feyza","family":"Alyu Alt\u0131nok","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, Anadolu University, 26470 Eski\u015fehir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0280-5550","authenticated-orcid":true,"given":"Ahmet","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eski\u015fehir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilhem","family":"Dallali","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Graduate School of Health Sciences, Anadolu University, 26470 Eski\u015fehir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3771-6910","authenticated-orcid":true,"given":"Ahmed","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Graduate School of Health Sciences, Anadolu University, 26470 Eski\u015fehir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurcan","family":"Bekta\u015f T\u00fcrkmen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, Anadolu University, 26470 Eski\u015fehir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf8924"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002130"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-018-2579-4"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.114.218065"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.87"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.2174\/1568009614666140122160515"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.2174\/092986712803414132"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.2174\/1574892809666140819153902"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.2174\/1381612826666200403124259"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.06.052"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2006.09.019"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.2174\/1871520615666150518093144"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00020"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2019.05.051"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2019.e01376"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2020.127173"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21081077"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01123"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1078\/094471103321659924"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3390\/molecules18022052"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.2174\/1568026617666170914160446"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.10.056"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.03.129"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2008.00639.x"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06232.x"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27207062"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115280"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.04.003"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/jm501100b"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2011.07.010"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2007.03.024"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.03.003"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2007.12.024"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.99311"},{"issue":"1","key":"ref35\/cit35","first-page":"3","volume":"20","author":"Vane J. R.","year":"1998","journal-title":"Int. J. Tissue React."},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23061250"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00284"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2006001200013"},{"issue":"2","key":"ref39\/cit39","first-page":"132","volume":"101","author":"Irwin S.","year":"1951","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.103699"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.207449"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-020-01320-y"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109347"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1177\/09603271211054436"},{"issue":"1","key":"ref45\/cit45","first-page":"96","volume":"166","author":"Vinegar R.","year":"1969","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-111-27849"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2017.1389897"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1017\/S0033583515000190"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.5b00642"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13101542"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2004.10.007"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.2298\/JSC220907001A"},{"issue":"3","key":"ref53\/cit53","first-page":"385","volume":"107","author":"Eddy N. B.","year":"1953","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"ref54\/cit54","first-page":"1","volume":"228","author":"Schmauss C.","year":"1984","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref55\/cit55","unstructured":"Koster, R.; Anderson, M.; De Beer, E. J. Acetic Acid for Analgesic Screening. In\n                      Federation Proceedings\n                      , 1959; Vol. 18; pp 412\u2013417."},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2009.04.001"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.4c00026","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.4c00026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T05:03:07Z","timestamp":1710219787000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.4c00026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,28]]},"references-count":56,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,3,12]]}},"alternative-id":["10.1021\/acsomega.4c00026"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.4c00026","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"value":"2470-1343","type":"print"},{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,28]]}}}