{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:23:11Z","timestamp":1791566591535,"version":"4.3.4"},"reference-count":34,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019155","name":"Nanjing Drum Tower Hospital","doi-asserted-by":"publisher","award":["2022-LCYJ-PY-40"],"award-info":[{"award-number":["2022-LCYJ-PY-40"]}],"id":[{"id":"10.13039\/501100019155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019349","name":"Nanjing Medical Science and Technique Development Foundation","doi-asserted-by":"publisher","award":["QRX17142"],"award-info":[{"award-number":["QRX17142"]}],"id":[{"id":"10.13039\/501100019349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019349","name":"Nanjing Medical Science and Technique Development Foundation","doi-asserted-by":"publisher","award":["YKK21066"],"award-info":[{"award-number":["YKK21066"]}],"id":[{"id":"10.13039\/501100019349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: Severe fever with thrombocytopenia syndrome (SFTS) is a serious infectious disease caused by the Dabie bandavirus, with a high mortality rate. Currently, there are no effective vaccines or specific treatments for SFTS. Early diagnosis and accurate severity assessment are crucial. Methods: This study included 171 cases of SFTS, COVID-19, and hepatitis B virus (HBV) patients and healthy controls. We compared the serum adenosine deaminase (ADA) activity across these groups. The diagnostic and prognostic efficiency of serum ADA for SFTS was evaluated by using receiver operating characteristic (ROC) curve analysis. We also examined the correlation between serum ADA in SFTS patients and clinical lab parameters as well as serum cytokines. Results: SFTS patients had significantly higher serum ADA activity than those of COVID-19, HBV patients, and healthy controls. Nonsurvivor SFTS patients had notably higher ADA than survivors. ROC analysis indicated ADA as an effective SFTS diagnostic and prognostic biomarker. ADA correlated with prognosis, viral load, APTT, PT, AST, ferritin, negatively with HDL-c and LDL-c, and positively with cytokines like IL-6, TNF-\u03b1, and IL-1\u03b2. Multiorgan failure patients showed significant ADA increase. Conclusion: Elevated serum ADA activity in SFTS patients is linked with disease severity and prognosis, showing potential as a diagnostic and prognostic biomarker for SFTS.<\/jats:p>","DOI":"10.1021\/acsomega.4c00281","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T17:35:55Z","timestamp":1708709755000},"page":"11005-11011","source":"Crossref","is-referenced-by-count":6,"title":["Adenosine Deaminase\nas a Potential Diagnostic and\nPrognostic Biomarker for Severe Fever with Thrombocytopenia Syndrome"],"prefix":"10.1021","volume":"9","author":[{"given":"Hongling","family":"Ye","sequence":"first","affiliation":[{"name":"Affiliated Hospital of Medical School, Nanjing University , , ,","place":["Nanjing, China, 210008"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiawen","family":"Lin","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Medical School, Nanjing University , , ,","place":["Nanjing, China, 210008"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Medical School, Nanjing University , , ,","place":["Nanjing, China, 210008"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiye","family":"Xu","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Medical School, Nanjing University , , ,","place":["Nanjing, China, 210008"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taihong","family":"Huang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Medical School, Nanjing University , , ,","place":["Nanjing, China, 210008"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Cai","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Medical School, Nanjing University , , ,","place":["Nanjing, China, 210008"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinyin","family":"Fan","sequence":"additional","affiliation":[{"name":"Nanjing University , , ,","place":["Nanjing, China, 210008"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5249-8434","authenticated-orcid":true,"given":"Sen","family":"Wang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Medical School, Nanjing University , , ,","place":["Nanjing, China, 210008"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,2,23]]},"reference":[{"key":"2026081709152961500_cit1","doi-asserted-by":"publisher","first-page":"1281600","DOI":"10.3389\/fmicb.2023.1281600","article-title":"Editorial: severe fever with thrombocytopenia\nsyndrome","volume":"14","author":"Hu","year":"2023","journal-title":"Front. Microbiol."},{"issue":"9","key":"2026081709152961500_cit2","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.3390\/microorganisms11092309","article-title":"Emerging\ntick-borne dabie bandavirus: virology, epidemiology,\nand prevention","volume":"11","author":"Kim","year":"2023","journal-title":"Microorganisms"},{"issue":"8","key":"2026081709152961500_cit3","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/S1473-3099(14)70718-2","article-title":"Severe fever with\nthrombocytopenia syndrome, an emerging tick-borne zoonosis","volume":"14","author":"Liu","year":"2014","journal-title":"Lancet Infect. Dis."},{"issue":"7","key":"2026081709152961500_cit4","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.3390\/v13071213","article-title":"Clinical update of\nsevere fever with\nthrombocytopenia syndrome","volume":"13","author":"Seo","year":"2021","journal-title":"Viruses"},{"key":"2026081709152961500_cit5","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.ijid.2018.05.013","article-title":"Analysis of clinical features and early warning indicators of death\nfrom severe fever with thrombocytopenia syndrome","volume":"73","author":"Xu","year":"2018","journal-title":"Int. J. Infect. Dis."},{"key":"2026081709152961500_cit6","doi-asserted-by":"publisher","first-page":"1209870","DOI":"10.3389\/fmicb.2023.1209870","article-title":"Trim3 attenuates cytokine\nstorm caused by dabie bandavirus via promoting\ntoll-like receptor 3 degradation","volume":"14","author":"Jin","year":"2023","journal-title":"Front. Microbiol."},{"issue":"20","key":"2026081709152961500_cit7","doi-asserted-by":"publisher","first-page":"4652","DOI":"10.3390\/molecules25204652","article-title":"Therapeutic\nperspectives of adenosine deaminase inhibition in cardiovascular diseases","volume":"25","author":"Kutryb-Zajac","year":"2020","journal-title":"Molecules"},{"issue":"14","key":"2026081709152961500_cit8","doi-asserted-by":"publisher","first-page":"7685","DOI":"10.3390\/ijms22147685","article-title":"Adenosine\nand inflammation: here, there and everywhere","volume":"22","author":"Pasquini","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"2026081709152961500_cit9","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.826","article-title":"Role of adenosine a2a\nreceptor in cancers and autoimmune diseases","volume":"11","author":"Ye","year":"2023","journal-title":"Immun., Inflammation Dis."},{"issue":"3","key":"2026081709152961500_cit10","doi-asserted-by":"publisher","first-page":"418","DOI":"10.3390\/biom12030418","article-title":"Adenosine-metabolizing\nenzymes, adenosine kinase and adenosine deaminase, in cancer","volume":"12","author":"Zhulai","year":"2022","journal-title":"Biomolecules"},{"issue":"2","key":"2026081709152961500_cit11","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s12026-018-8984-9","article-title":"Serum adenosine\ndeaminase activity\nis increased in systemic lupus erythematosus patients and correlated\nwith disease activity","volume":"66","author":"Gao","year":"2018","journal-title":"Immunol. Res."},{"issue":"1","key":"2026081709152961500_cit12","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s12865-022-00477-5","article-title":"Increased\nserum adenosine deaminase\nactivity in patients with adult-onset still\u2019s disease","volume":"23","author":"Xu","year":"2022","journal-title":"BMC Immunol."},{"key":"2026081709152961500_cit13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.imlet.2023.04.010","article-title":"Correlation\nof serum adenosine deaminase activity with disease activity\nin patients with primary sjogren\u2019s syndrome","volume":"258","author":"Zhang","year":"2023","journal-title":"Immunol. Lett."},{"issue":"10","key":"2026081709152961500_cit14","first-page":"3126","article-title":"Diagnosis of tuberculosis\npleurisy with adenosine deaminase (ada):\na systematic review and meta-analysis","volume":"7","author":"Gui","year":"2014","journal-title":"Int.\nJ. Clin. Exp. Med."},{"issue":"3","key":"2026081709152961500_cit15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0213728","article-title":"Adenosine\ndeaminase for diagnosis of tuberculous pleural effusion: a systematic\nreview and meta-analysis","volume":"14","author":"Aggarwal","year":"2019","journal-title":"PLoS One"},{"key":"2026081709152961500_cit16","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.imlet.2018.04.006","article-title":"Adenosine\nsignaling and the immune system: when a lot could be too much","volume":"205","author":"Antonioli","year":"2019","journal-title":"Immunol. Lett."},{"key":"2026081709152961500_cit17","doi-asserted-by":"publisher","first-page":"903461","DOI":"10.3389\/fimmu.2022.903461","article-title":"Distinct roles\nof adenosine deaminase\nisoenzymes ada1 and ada2: a pan-cancer analysis","volume":"13","author":"Gao","year":"2022","journal-title":"Front. Immunol."},{"issue":"15","key":"2026081709152961500_cit18","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1182\/blood.2021012300","article-title":"Built to\nlast: gene therapy for ada scid","volume":"138","author":"Pai","year":"2021","journal-title":"Blood"},{"issue":"1","key":"2026081709152961500_cit19","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/j.1365-2249.2004.02591.x","article-title":"Macrophages are\na source of extracellular adenosine\ndeaminase-2 during inflammatory responses","volume":"138","author":"Conlon","year":"2004","journal-title":"Clin.\nExp. Immunol."},{"issue":"2","key":"2026081709152961500_cit20","first-page":"266","article-title":"Adenosine deaminase\nisoenzymes in liver disease","volume":"88","author":"Kobayashi","year":"1993","journal-title":"Am. J. Gastroenterol."},{"issue":"07+08\/2013","key":"2026081709152961500_cit21","doi-asserted-by":"publisher","first-page":"757","DOI":"10.7754\/Clin.Lab.2012.120631","article-title":"Diagnostic value of serum adenosine\ndeaminase activity\nin hiv infected patients of kurdish population","volume":"59","author":"Abdi","year":"2013","journal-title":"Clin. Lab."},{"issue":"3","key":"2026081709152961500_cit22","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1002\/jcla.21836","article-title":"Serum adenosine\ndeaminase (ada) activity: a novel screening\ntest to differentiate hiv monoinfection from hiv-hbv and hiv-hcv coinfections","volume":"30","author":"Abdi","year":"2016","journal-title":"J. Clin. Lab. Anal."},{"issue":"1","key":"2026081709152961500_cit23","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1080\/22221751.2022.2157338","article-title":"Correlations\nof myeloperoxidase (mpo), adenosine deaminase (ada), c\u2013c motif\nchemokine 22 (ccl22), tumour necrosis factor alpha (tnf\u03b1) and\ninterleukin-6 (il-6) mrna expression in the nasopharyngeal specimens\nwith the diagnosis and severity of SARS-cov-2 infections","volume":"12","author":"Chiu","year":"2023","journal-title":"Emerg Microbes Infect."},{"issue":"1","key":"2026081709152961500_cit24","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1186\/s12879-020-05303-0","article-title":"Severe fever with thrombocytopenia\nsyndrome: a systematic review and meta-analysis of epidemiology, clinical\nsigns, routine laboratory diagnosis, risk factors, and outcomes","volume":"20","author":"He","year":"2020","journal-title":"BMC Infect. Dis."},{"key":"2026081709152961500_cit25","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.ijid.2022.10.008","article-title":"Fatal\npatients with severe fever with thrombocytopenia syndrome in china","volume":"125","author":"Zhao","year":"2022","journal-title":"Int. J. Infect. Dis."},{"key":"2026081709152961500_cit26","doi-asserted-by":"publisher","first-page":"1239420","DOI":"10.3389\/fmicb.2023.1239420","article-title":"Association\nof low hdl-c levels with\nsevere symptoms and poor clinical prognosis in patients with severe\nfever and thrombocytopenia syndrome","volume":"14","author":"Huang","year":"2023","journal-title":"Front.\nMicrobiol."},{"issue":"12","key":"2026081709152961500_cit27","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1111\/j.1365-2362.2010.02361.x","article-title":"The versatility\nof hdl: a crucial\nanti-inflammatory regulator","volume":"40","author":"Saemann","year":"2010","journal-title":"Eur. J. Clin. Invest."},{"issue":"6","key":"2026081709152961500_cit28","doi-asserted-by":"publisher","first-page":"667","DOI":"10.2174\/092986709787458425","article-title":"The anti inflammatory\neffects of high density lipoproteins","volume":"16","author":"Murphy","year":"2009","journal-title":"Curr.\nMed. Chem."},{"issue":"7","key":"2026081709152961500_cit29","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28894","article-title":"Fatal\noutcome of severe fever with thrombocytopenia\nsyndrome (SFTS) and severe and critical COVID-19 is associated with\nthe hyperproduction of IL-10 and IL-6 and the low production of TGF-\u03b2","volume":"95","author":"Kang","year":"2023","journal-title":"J. Med. Virol."},{"issue":"5","key":"2026081709152961500_cit30","doi-asserted-by":"publisher","first-page":"876","DOI":"10.3390\/v13050876","article-title":"The role of non-structural protein\nnss in the pathogenesis of severe fever with thrombocytopenia syndrome","volume":"13","author":"Khalil","year":"2021","journal-title":"Viruses"},{"issue":"1","key":"2026081709152961500_cit31","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s12985-016-0677-1","article-title":"Correlation of cytokine\nlevel with the severity of severe fever with thrombocytopenia syndrome","volume":"14","author":"Liu","year":"2017","journal-title":"Virol. J."},{"key":"2026081709152961500_cit32","doi-asserted-by":"publisher","first-page":"711847","DOI":"10.3389\/fimmu.2021.711847","article-title":"Il-6\nand il-10 levels, rather than viral load and neutralizing antibody\ntiters, determine the fate of patients with severe fever with thrombocytopenia\nsyndrome virus infection in south korea","volume":"12","author":"Yoo","year":"2021","journal-title":"Front.\nImmunol."},{"key":"2026081709152961500_cit33","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1016\/j.ijbiomac.2019.09.078","article-title":"Adenosine\ndeaminase inhibition","volume":"141","author":"Bagheri","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"6","key":"2026081709152961500_cit34","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1093\/infdis\/131.6.673","article-title":"Antiviral activity\nof an adenosine deaminase inhibitor:\ndecreased replication of herpes simplex virus","volume":"131","author":"Williams","year":"1975","journal-title":"J. Infect. Dis."}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.4c00281","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/9\/9\/11005\/4432956\/ao4c00281.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/9\/9\/11005\/4432956\/ao4c00281.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T13:41:33Z","timestamp":1786974093000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/acsodf\/article\/9\/9\/11005\/411099\/Adenosine-Deaminase-as-a-Potential-Diagnostic-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,23]]},"references-count":34,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,2,23]]},"published-print":{"date-parts":[[2024,3,5]]}},"URL":"https:\/\/doi.org\/10.1021\/acsomega.4c00281","relation":{},"ISSN":["2470-1343"],"issn-type":[{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,23]]}}}