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The foam and the compact iron samples were coated with a polyethylene glycol (PEG) polymer layer without and with gentamicin sulfate (PEG + Ge). The corrosion properties of coated and uncoated samples were studied using the degradation testing in Hanks\u2019 solution at 37 \u00b0C. The electrochemical and static immersion corrosion tests revealed that the PEG-coated samples corroded faster than samples with the bioactive PEG + Ge coating and uncoated samples. The foam samples corroded faster compared with the compact samples. To determine the cytotoxicity, cell viability was monitored in the presence of porous foam and compact iron samples. The antibacterial activity of the samples with PEG and PEG + Ge against Escherichia coli CCM 3954 and Staphylococcus aureus CCM 4223 strains was also tested. Tested PEG + Ge samples showed significant antibacterial activity against both bacterial strains. Therefore, the biodegradable iron-based materials with a bioactive coating could be a suitable successor to the metal materials studied thus far as well as the materials used in the field of medicine.<\/jats:p>","DOI":"10.1021\/acsomega.4c01002","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T19:33:26Z","timestamp":1718220806000},"page":"27113-27126","source":"Crossref","is-referenced-by-count":5,"title":["Effect of Gentamicin\nSulfate and Polymeric Polyethylene\nGlycol Coating on the Degradation and Cytotoxicity of Iron-Based Biomaterials"],"prefix":"10.1021","volume":"9","author":[{"given":"Martina","family":"Petra\u0301kova\u0301","sequence":"first","affiliation":[{"name":"P. J. S\u030cafa\u0301rik University in Kos\u030cice , , Moyzesova 11 , ,","place":["Kos\u030cice, Slovakia, 041\n01"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radka","family":"Gorejova\u0301","sequence":"additional","affiliation":[{"name":"P. J. 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S\u030cafa\u0301rik University in Kos\u030cice , , Moyzesova 11 , ,","place":["Kos\u030cice, Slovakia, 041\n01"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Kupkova\u0301","sequence":"additional","affiliation":[{"name":"Slovak Academy of Sciences , , Watsonova 47 , ,","place":["Kos\u030cice, Slovakia, 040 01"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matej","family":"Mic\u030cus\u030ci\u0301k","sequence":"additional","affiliation":[{"name":"Slovak Academy of Sciences , , Du\u0301bravska\u0301 cesta 9 , ,","place":["Bratislava, Slovakia, 845 41"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6563-7588","authenticated-orcid":true,"given":"Matej","family":"Bala\u0301z\u030c","sequence":"additional","affiliation":[{"name":"Slovak Academy of Sciences , , Watsonova 45 , ,","place":["Kos\u030cice, Slovakia, 040 01"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanda","family":"Hajduc\u030ckova\u0301","sequence":"additional","affiliation":[{"name":"University of Veterinary Medicine and Pharmacy in Kos\u030cice , , Komenske\u0301ho 73 , ,","place":["Kos\u030cice, Slovakia, 041 81"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patri\u0301cia","family":"Hudecova\u0301","sequence":"additional","affiliation":[{"name":"University of Veterinary Medicine and Pharmacy in Kos\u030cice , , Komenske\u0301ho 73 , ,","place":["Kos\u030cice, Slovakia, 041 81"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Koz\u030ca\u0301r","sequence":"additional","affiliation":[{"name":"The University of Veterinary Medicine and Pharmacy in Kos\u030cice , , ,","place":["Kos\u030cice, Slovakia, 040 01"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbora","family":"S\u030cis\u030ckova\u0301","sequence":"additional","affiliation":[{"name":"The University of Veterinary Medicine and Pharmacy in Kos\u030cice , , ,","place":["Kos\u030cice, Slovakia, 040 01"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Sa\u0301ha","sequence":"additional","affiliation":[{"name":"University Institute, Toma\u0301s\u030c Bat\u2019a University in Zli\u0301n , , Tr\u030cida Toma\u0301s\u030ce Bati 5678 , ,","place":["Zli\u0301n, Czech Republic, 76001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8103-2634","authenticated-orcid":true,"given":"Rena\u0301ta","family":"Orin\u030cakova\u0301","sequence":"additional","affiliation":[{"name":"P. 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Surf. Sci."},{"key":"2026081709090532500_cit42","doi-asserted-by":"publisher","first-page":"4134","DOI":"10.3390\/ma13184134","article-title":"Degradation performance\nof open-cell biomaterials from phosphated carbonyl iron powder with\nPEG coating","volume":"13","author":"Orin\u030cakova\u0301","year":"2020","journal-title":"Materials"},{"key":"2026081709090532500_cit43","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.jmst.2021.08.089","article-title":"Enhanced corrosion\nresistance, antibacterial activity and biocompatibility of gentamicin-montmorillonite\ncoating on Mg alloy-in vitro and in vivo studies","volume":"111","author":"Fan","year":"2022","journal-title":"J. Mater. Sci. Technol."},{"key":"2026081709090532500_cit44","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1016\/j.jma.2020.06.011","article-title":"Corrosion resistance\nand superhydrophobicity of one-step polypropylene coating on anodized\nAZ31 Mg alloy","volume":"9","author":"Zhang","year":"2021","journal-title":"Journal of Magnesium and Alloys"},{"key":"2026081709090532500_cit45","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/acd49b","article-title":"Degradation\nbehavior, cytotoxicity, hemolysis of partially\nunzipped carbon nanotubes\/zinc composites as potential biodegradable\nbone implants","volume":"18","author":"Yang","year":"2023","journal-title":"Biomedical Materials"},{"key":"2026081709090532500_cit46","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1002\/maco.202313751","article-title":"Technical note on\nthe determination of degradation\nrates of biodegradable magnesium implants","volume":"74","author":"Zeller-Plumhoff","year":"2023","journal-title":"Materials\nand Corrosion"},{"key":"2026081709090532500_cit47","doi-asserted-by":"publisher","first-page":"289","DOI":"10.2147\/IJN.S7137","article-title":"Antibacterial\nefficacy of core-shell nanostructures encapsulating gentamicin against\nan in vivo intracellular Salmonella model","volume":"4","author":"Ranjan","year":"2009","journal-title":"Int.\nJ. Nanomedicine"},{"key":"2026081709090532500_cit48","doi-asserted-by":"publisher","first-page":"37","DOI":"10.22203\/eCM.v008a05","article-title":"Concise review of mechanisms\nof bacterial adhesion to biomaterials and of techniques used in estimating\nbacteria-material interactions","volume":"8","author":"Katsikogianni","year":"2004","journal-title":"Eur. Cell Mater."},{"key":"2026081709090532500_cit49","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.jmst.2021.08.089","article-title":"Enhanced corrosion\nresistance, antibacterial activity and biocompatibility of gentamicin-montmorillonite\ncoating on Mg alloy-in vitro and in vivo studies","volume":"111","author":"Fan","year":"2022","journal-title":"J. Mater. Sci. 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