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This study described the synthesis and characterization of CCM-Co-ZIF-8, a novel composite material with enzyme-like activities similar to catalase, peroxidase, and superoxide dismutase. CCM-Co-ZIF-8 demonstrated the ability to scavenge reactive oxygen species that play a critical role in UC pathogenesis. In vitro studies using lipopolysaccharide-induced RAW264.7 cells showed that CCM-Co-ZIF-8 exhibited anti-inflammatory activity by promoting the transition of macrophages from an M1 to an M2 phenotype. In vivo experiments using a mouse model of UC demonstrated that CCM-Co-ZIF-8 suppressed the expression of proinflammatory cytokines. These findings suggested that CCM-Co-ZIF-8 might hold promise as a therapeutic strategy for the treatment of UC.<\/jats:p>","DOI":"10.1021\/acsomega.4c02446","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T06:21:46Z","timestamp":1720074106000},"page":"30571-30582","source":"Crossref","is-referenced-by-count":24,"title":["Curcumin-Encapsulated Co-ZIF\u20118 for Ulcerative\nColitis Therapy: ROS Scavenging and Macrophage Modulation Effects"],"prefix":"10.1021","volume":"9","author":[{"given":"Qi","family":"Tao","sequence":"first","affiliation":[{"name":"Yangzhou University , , ,","place":["Yangzhou, P. R. China, 225002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Yao","sequence":"additional","affiliation":[{"name":"Yangzhou University , , ,","place":["Yangzhou, P. R. 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