{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T14:30:50Z","timestamp":1760711450173,"version":"3.37.3"},"reference-count":90,"publisher":"American Chemical Society (ACS)","issue":"46","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","doi-asserted-by":"publisher","award":["465389\/2014-7"],"award-info":[{"award-number":["465389\/2014-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo","doi-asserted-by":"publisher","award":["14\/50299-5","14\/50867-3","16\/22215-7","17\/01189-0","19\/15040-4","20\/05965-8"],"award-info":[{"award-number":["14\/50299-5","14\/50867-3","16\/22215-7","17\/01189-0","19\/15040-4","20\/05965-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior","doi-asserted-by":"publisher","award":["001","88887.466921\/2019-00","88887.504531\/2020-00"],"award-info":[{"award-number":["001","88887.466921\/2019-00","88887.504531\/2020-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2024,11,19]]},"DOI":"10.1021\/acsomega.4c02557","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T16:04:00Z","timestamp":1730909040000},"page":"45746-45758","source":"Crossref","is-referenced-by-count":3,"title":["Multiplatform Metabolomics: Enhancing the Severity Risk Prognosis of SARS-CoV-2 Infection"],"prefix":"10.1021","volume":"9","author":[{"given":"Vinicius S.","family":"Lima","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Medicina Translacional, Departamento de Medicina, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo 04023-062, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinara T. B.","family":"Morais","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica de S\u00e3o Carlos, Universidade de S\u00e3o Paulo, S\u00e3o Carlos 13566-590, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinicius G.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica de S\u00e3o Carlos, Universidade de S\u00e3o Paulo, S\u00e3o Carlos 13566-590, Brazil"},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Bioanal\u00edtica, INCTBio, Campinas 13083-861, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana B.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica de S\u00e3o Carlos, Universidade de S\u00e3o Paulo, S\u00e3o Carlos 13566-590, Brazil"},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Bioanal\u00edtica, INCTBio, Campinas 13083-861, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel Pedro Barros","family":"Silva","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Medicina Translacional, Departamento de Medicina, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo 04023-062, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thais","family":"de A. Lopes","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidade Federal de S\u00e3o Carlos, S\u00e3o Carlos, S\u00e3o Paulo 13565-905, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana M.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidade Federal de S\u00e3o Carlos, S\u00e3o Carlos, S\u00e3o Paulo 13565-905, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5215-0997","authenticated-orcid":true,"given":"Joyce R. S.","family":"Raimundo","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina do ABC, Santo Andr\u00e9, S\u00e3o Paulo 09060-870, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle Z. S.","family":"Furtado","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Medicina Translacional, Departamento de Medicina, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo 04023-062, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando L. A.","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina do ABC, Santo Andr\u00e9, S\u00e3o Paulo 09060-870, Brazil"},{"name":"Departamento de Qu\u00edmica, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo 05508-070, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina V.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidade Federal de S\u00e3o Carlos, S\u00e3o Carlos, S\u00e3o Paulo 13565-905, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3492-3327","authenticated-orcid":true,"given":"Daniel R.","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica de S\u00e3o Carlos, Universidade de S\u00e3o Paulo, S\u00e3o Carlos 13566-590, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7351-8220","authenticated-orcid":true,"given":"Emanuel","family":"Carrilho","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica de S\u00e3o Carlos, Universidade de S\u00e3o Paulo, S\u00e3o Carlos 13566-590, Brazil"},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Bioanal\u00edtica, INCTBio, Campinas 13083-861, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilson A.","family":"Assun\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Medicina Translacional, Departamento de Medicina, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo 04023-062, Brazil"},{"name":"Departamento de Qu\u00edmica, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo 05508-070, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-25719-9"},{"key":"ref2\/cit2","unstructured":"Our\nWorld in Data.  Mortality Risk of COVID-19. https:\/\/ourworldindata.org\/mortality-risk-covid (accessed 18 10 2022)."},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwaa086"},{"key":"ref4\/cit4","unstructured":"Centers of Disease Control\nand Prevention.  CDC 2020 in Review, 2020. https:\/\/www.cdc.gov\/media\/releases\/2020\/p1229-cdc-2020-review.html (accessed 18 10 2022)."},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2548-6"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26085"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S325853"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.202200118"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-53721-1"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4978018"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12080768"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2022.2092941"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.06.016"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.0c00519"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.686240"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0259909"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-022-01904-9"},{"key":"ref18\/cit18","unstructured":"World\nHealth Organization.  Diagnostic testing\nfor SARS-CoV-2: interim\nguidance. https:\/\/www.who.int\/docs\/default-source\/coronaviruse\/corrigenda-ig-2020-6-diagnostic-texting-2020-09-11-corr-2020-09-15-en.pdf?sfvrsn=a924054d_2 (accessed 18 10 2022)."},{"key":"ref200\/ref200_1","doi-asserted-by":"publisher","unstructured":"Bibbins-Domingo, K.; Brubaker, L.; Curfman, G. The 2024 Revision to the Declaration of Helsinki: Modern Ethics for Medical Research. JAMA, Published online October 19, 2024. 10.1001\/jama.2024.22530.","DOI":"10.1001\/jama.2024.22530"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-021-00425-4"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2021.100369"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.10.037"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-05667-0"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-85788-0"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11120847"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.1c00977"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1097\/CCE.0000000000000272"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0270914"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c09371"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.2c00148"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.0c04590"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.2174\/2213235X11301010092"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.3390\/metabo9120308"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/cpbi.86"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/s10038-020-0763-5"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201900126"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-017-1215-1"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1177\/1177932219899051"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2019.05.030"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-020-01364-6"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108313"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0256784"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/783730"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12050376"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2016.03.020"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2009.11.004"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-007-0625-x"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1515\/pterid-2013-0001"},{"key":"ref48\/cit48","first-page":"2538","volume":"7","author":"Golab F.","year":"2022","journal-title":"J. Med. Physiol."},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2021-328516"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.23937\/2474-3658\/1510243"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-018-0893-4"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00561"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)00928-X"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.013116"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00338-21"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12896"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-020-02933-1"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-020-01765-z"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005640"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-82426-7"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116195"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21103544"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.3390\/v13010090"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.107"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2017.02.005"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222212597"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.73057"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.7883\/yoken.jjid.2005.131"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.844283"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.05.032"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1101\/2020.07.09.20149849"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.0c04497"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01463-17"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30937-5"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.c18-00954"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2020.104971"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228623"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1038\/nri2974"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00510-10"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.3390\/v11100912"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2014-0273"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197189"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-09536-z"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2009.06.003"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-021-01859-3"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.3390\/cells10092293"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2016.01.023"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1039\/C8RA05640D"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.655837"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.4c02557","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.4c02557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T10:08:44Z","timestamp":1732010924000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.4c02557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,6]]},"references-count":90,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2024,11,19]]}},"alternative-id":["10.1021\/acsomega.4c02557"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.4c02557","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"type":"print","value":"2470-1343"},{"type":"electronic","value":"2470-1343"}],"subject":[],"published":{"date-parts":[[2024,11,6]]}}}