{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T04:19:43Z","timestamp":1789618783094,"version":"build-2803163510"},"reference-count":30,"publisher":"American Chemical Society (ACS)","issue":"28","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000146","name":"Division of Chemical, Bioengineering, Environmental, and Transport Systems","doi-asserted-by":"publisher","award":["2230355"],"award-info":[{"award-number":["2230355"]}],"id":[{"id":"10.13039\/100000146","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Central to the production of polyethylene furanoate (PEF), a bioplastic that could potentially replace petroleum-derived plastics, is 2,5-furandicarboxylic acid (FDCA). FDCA is a chemical derived from biomass that has low solubility in traditionally used solvents such as water. Thus, identifying solvents that can solubilize significant amounts of FDCA could allow for lower PEF production costs. In this study, FDCA solubility was investigated in nine pure solvents including H2O, acetonitrile (ACN), \u03b3-valerolactone (GVL), \u03b3-butyrolactone (GBL), ethanol (EtOH), methanol (MeOH), dimethyl sulfoxide (DMSO), sulfolane (SULF), and tetrahydrofuran (THF), eight binary, and three ternary solvent blends at 293 K. For all binary systems excluding DMSO and MeOH, the solubility of FDCA increased 1.5\u201365 times compared to the pure organic solvent, and the FDCA solubility was at least 10 times higher when compared to pure water. Specifically, the 20\/80 w\/w H2O\/DMSO system solubilized 23.1 wt % FDCA, the highest of any binary blend studied, and 190 times more solubility than in pure water. In 20\/80 w\/w H2O\/THF, the FDCA solubility was 60 times higher than pure water. In ternary blends that included DMSO, H2O, and either GVL, THF, or SULF, solubility increased by at least 6.6 times relative to the pure secondary organic component and 54 times relative to pure water. Using Hansen solubility parameters (HSPs), the radius of interaction (Ri,\u00a0j) was found to be more strongly correlated to FDCA solubility than individual HSPs or the total solubility parameter. A MATLAB-based optimization code was developed and successful in minimizing the Ri,\u00a0j of a solvent blend to maximize FDCA solubility in binary and ternary aqueous solvents.<\/jats:p>","DOI":"10.1021\/acsomega.4c03170","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T04:53:46Z","timestamp":1720155226000},"page":"30708-30716","source":"Crossref","is-referenced-by-count":10,"title":["Solubility of 2,5-Furandicarboxylic\nAcid in Pure and\nMixed Organic Solvent Systems at 293 K Predicted Using Hansen Solubility\nParameters"],"prefix":"10.1021","volume":"9","author":[{"given":"Jacob\nM.","family":"Molinaro","sequence":"first","affiliation":[{"name":"Montana State University , , P.O. Box 173920 , , ,","place":["Bozeman, Montana, United States, 59717"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Carroll","sequence":"additional","affiliation":[{"name":"Montana State University , , P.O. Box 173920 , , ,","place":["Bozeman, Montana, United States, 59717"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabelle S.","family":"Young","sequence":"additional","affiliation":[{"name":"Montana State University , , P.O. Box 173920 , , ,","place":["Bozeman, Montana, United States, 59717"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4437-3701","authenticated-orcid":true,"given":"Stephanie G.","family":"Wettstein","sequence":"additional","affiliation":[{"name":"Montana State University , , P.O. Box 173920 , , ,","place":["Bozeman, Montana, United States, 59717"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"2026081708342138300_cit1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27051599","article-title":"The Cradle-to-Cradle\nLife Cycle Assessment of Polyethylene terephthalate: Environmental\nPerspective","volume":"27","author":"Tamoor","year":"2022","journal-title":"Molecules"},{"key":"2026081708342138300_cit2","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.ymben.2021.03.011","article-title":"Towards bio-upcycling\nof polyethylene terephthalate","volume":"66","author":"Tiso","year":"2021","journal-title":"Metab Eng."},{"key":"2026081708342138300_cit3","doi-asserted-by":"publisher","first-page":"2701","DOI":"10.1038\/s41467-018-05147-y","article-title":"Bottle-grade\npolyethylene furanoate from ring-opening polymerisation of cyclic\noligomers","volume":"9","author":"Rosenboom","year":"2018","journal-title":"Nat. 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