{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T09:13:21Z","timestamp":1789636401112,"version":"4.0.0"},"reference-count":81,"publisher":"American Chemical Society (ACS)","issue":"36","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013920","name":"Uniwersytet im. Adama Mickiewicza w Poznaniu","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013920","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2024,9,10]]},"DOI":"10.1021\/acsomega.4c04800","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T19:17:56Z","timestamp":1724959076000},"page":"37995-38014","source":"Crossref","is-referenced-by-count":4,"title":["Exploring Triazole-Connected Steroid-Pyrimidine Hybrids: Synthesis, Spectroscopic Characterization, and Biological Assessment"],"prefix":"10.1021","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9281-7103","authenticated-orcid":true,"given":"Anna","family":"Kawka","sequence":"first","affiliation":[{"name":"Department of Bioactive Products, Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Pozna\u0144skiego 8 Street, 61-614 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3739-3306","authenticated-orcid":true,"given":"Damian","family":"Nowak","sequence":"additional","affiliation":[{"name":"Department of Quantum Chemistry, Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Pozna\u0144skiego 8 Street, 61-614 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Koenig","sequence":"additional","affiliation":[{"name":"Department of Bioactive Products, Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Pozna\u0144skiego 8 Street, 61-614 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5071-7016","authenticated-orcid":true,"given":"Tomasz","family":"Pospieszny","sequence":"additional","affiliation":[{"name":"Department of Bioactive Products, Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Pozna\u0144skiego 8 Street, 61-614 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2003.12.002"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/B978-0-323-51254-1.00003-8","volume-title":"Emerging Applications of Nanoparticles and Architecture Nanostructures","author":"Sharma A.","year":"2018"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1177\/095632020101200304"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24203676"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.04.075"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26123678"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2005.03.001"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2006.09.013"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2016.09.014"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2013.08.029"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-1280(00)00556-X"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","unstructured":"Dewick, P. M. Medicinal Natural Products: A Biosynthetic Approach, 3rd ed. Wiley, A John Wiley and Sons, Ltd., 2009; pp 247\u2013298.","DOI":"10.1002\/9780470742761"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2017.12.005"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01811-6"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27227830"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2022.106036"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2021.108798"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2016.03.005"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.04.024"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26010025"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3146"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c07034"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/bc8001826"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.9b03425"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1002\/pat.5478"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1039\/b904091a"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA10097J"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/med.20107"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2019.00081"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1039\/D3MD00411B"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00574"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.11.028"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2012.10.008"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/jm3004174"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2019.04.076"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.2174\/0929867330666230228120416"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2014.04.011"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2014.05.013"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2019.108548"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2018.09.006"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2010.10.013"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.3390\/molecules18044613"},{"key":"ref43\/cit43","unstructured":"CAChe\n5.04 UserGuide; Fujitsu: Chiba, Japan, 2003."},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.540120306"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.540100208"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2022.134313"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.201500118"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(01)00393-5"},{"key":"ref49\/cit49","unstructured":"Pharma Expert Predictive Services \u00a920112013,\nVersion 2.0. http:\/\/www.pharmaexpert.ru\/PASSOnline\/."},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/ci000383k"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023836829456"},{"key":"ref52\/cit52","doi-asserted-by":"crossref","unstructured":"Poroikov, V. V.; Filimonov, D. A. Predictive Toxicology; Helma, C., Ed. Taylor and Francis: Boca Raton, Florida, USA, 2005; pp 459\u2013478.","DOI":"10.1201\/9780849350351.ch13"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1021\/ci00057a005"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/ja00290a017"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-3-33"},{"key":"ref56\/cit56","unstructured":"Open Babel Development Team. Open Babel, Version: 3.1.1. 2020 http:\/\/openbabel.org\/wiki\/Main_Page. (accessed on April 25, 2024)."},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.235"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m004132200"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M004132200"},{"key":"ref60\/cit60","doi-asserted-by":"crossref","unstructured":"Lafitte, D.; Lamour, V.; Tsvetkov, P. O.; Makarov, A. A.; Klich, M.; Deprez, P.; Moras, D.; Briand, C.; Gilli, R. Crystal Structure of E. coli 24 kDa Domain in Complex with Clorobiocin. 2002.","DOI":"10.2210\/pdb1kzn\/pdb"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1021\/bi0159837"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb1113"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb1113"},{"key":"ref64\/cit64","doi-asserted-by":"crossref","unstructured":"Chopra, R.; Bard, J.; Svenson, K.; Mansour, T. Crystal Structure of E. Coli Mur B bound to a Naphthyl Tetronic Acid inihibitor. 2007.","DOI":"10.2210\/pdb2q85\/pdb"},{"key":"ref65\/cit65","unstructured":"Mansour, T.; Caulfield, C. E.; Rasmussen, B.; Chopra, R.; Krishnamurthy, G.; Morris, K. M.; Svenson, K.; Bard, J.; Smeltzer, C.; Naughton, S.; Antane, S.; Yang, Y.; Severin, A.; Quagliato, D.; Petersen, P. J.; Singh, G. Crystal Structure of E. Coli Mur B bound to a napthyl tetronic acid inhibitor. To be published."},{"key":"ref66\/cit66","doi-asserted-by":"crossref","unstructured":"Keniya, M. V.; Sabherwal, M.; Wilson, R. K.; Sagatova, A. A.; Tyndall, J. D. A.; Monk, B. C. Structure of CYP51 from the pathogen Candida albicans. 2017.","DOI":"10.2210\/pdb5v5z\/pdb"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01134-18"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21256"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21334"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20084"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1042\/bse0590001"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.03.070"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-011-3557-z"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29020550"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03289.x"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2019.02.012"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.778308"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.1243"},{"key":"ref79\/cit79","unstructured":"Landrum, G. RDKit: Open-Source Cheminformatics Software. 2022."},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1021\/jp980230o"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23051038"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.4c04800","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.4c04800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T11:42:46Z","timestamp":1725968566000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.4c04800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,29]]},"references-count":81,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2024,9,10]]}},"alternative-id":["10.1021\/acsomega.4c04800"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.4c04800","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"value":"2470-1343","type":"print"},{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,29]]}}}