{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:42:59Z","timestamp":1793508179802,"version":"4.5.0"},"reference-count":228,"publisher":"American Chemical Society (ACS)","issue":"45","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001322","name":"South African Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Perivoli Africa Research Center, University of Bristol","id":[{"id":"https:\/\/ror.org\/0524sp257","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2025,11,18]]},"DOI":"10.1021\/acsomega.4c04887","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:34:02Z","timestamp":1762562042000},"page":"53633-53657","source":"Crossref","is-referenced-by-count":7,"title":["Nanomedicine Solutions for Alzheimer\u2019s Disease: A Critical Review of Therapeutic Nanoparticle Strategies"],"prefix":"10.1021","volume":"10","author":[{"given":"Teboho E.","family":"Tutubala","sequence":"first","affiliation":[{"name":"Discipline of Pharmaceutical Chemistry, School of Pharmacy, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayodeji O.","family":"Egunlusi","sequence":"additional","affiliation":[{"name":"Discipline of Pharmaceutical Chemistry, School of Pharmacy, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa"},{"name":"Division of Pharmaceutical Chemistry, Faculty of Pharmacy, Rhodes University, PO Box 94, Makhanda 6140, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Medical Biosciences, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5684-6094","authenticated-orcid":true,"given":"Admire","family":"Dube","sequence":"additional","affiliation":[{"name":"Discipline of Pharmaceutics, School of Pharmacy, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0378-7091","authenticated-orcid":true,"given":"Jacques","family":"Joubert","sequence":"additional","affiliation":[{"name":"Discipline of Pharmaceutical Chemistry, School of Pharmacy, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,11,7]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317520937542"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.2174\/1574884715666200628112844"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-011146"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12545"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-215730"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-022-00338-8"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1177\/1179573520907397"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.630055"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.3371\/CSRP.LGMM.082121"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14112296"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22136818"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174310"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.9734\/jpri\/2020\/v32i1030488"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2022.05.025"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14010194"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.20517\/and.2023.16"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2022.105514"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008239"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01192"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.2c00300"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115297"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.93269"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.162743"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2019.01.021"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02584-x"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101496"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-015-9460-9"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-019-0609-7"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12385"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1063\/5.0095072"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2017.28"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1039\/C8NR09221D"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111575"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.332127"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001694"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.4478"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1126\/science.1255555"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115911"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231810572"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.10.018"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2019-0443"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1134\/S002689332104004X"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.651215"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-013-1423-y"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-020-00376-6"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23137273"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.3928\/00989134-20221205-02"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10367"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12789"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2006.10.013"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190062"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00757-x"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2021.102129"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.4137\/PMC.S13384"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.12.015"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20020381"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1177\/2041731419897460"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-016-1958-5"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.01.044"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3702518"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1039\/D2DT03149C"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-021-00864-x"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.11.027"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2007.06.023"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.52586\/4992"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2018.1461955"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.05.044"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2012.06.011"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1021\/nn300489k"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.2174\/1389201015666140508122558"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.07.007"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2007.01.016"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.2174\/1389450120666191118123151"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10071706"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1080\/02652048.2020.1756971"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-020-00754-z"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.11.047"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2017.11.001"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.120040"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032616"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.11.050"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1080\/1061186X.2023.2216405"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.01.039"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.11.021"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-2116-9_6"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.3390\/biom9120773"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1080\/14728214.2019.1654455"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","unstructured":"Neuhofer, C., Development of lipid based depot formulations using interferon-beta-1b as a model protein.\n                      PhD Thesis\n                      ; 2015. 10.5282\/edoc.18948.","DOI":"10.5282\/edoc.18948"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-016-0615-8"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13010038"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1002\/alz.069264"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2022.103631"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2015.04.006"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2020.101724"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12030251"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.1007\/s10924-021-02349-2"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-021-02096-0"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.121720"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmt.2021.101303"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2022.147786"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.2174\/1567201815666181004094707"},{"key":"ref102\/cit102","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2021-0051"},{"key":"ref103\/cit103","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120482"},{"key":"ref104\/cit104","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-021-03487-1"},{"key":"ref105\/cit105","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.8b00537"},{"key":"ref106\/cit106","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.9b00505"},{"key":"ref107\/cit107","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-022-02449-9"},{"key":"ref108\/cit108","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2022.212870"},{"key":"ref109\/cit109","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abq0095"},{"key":"ref110\/cit110","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.8b00388"},{"key":"ref111\/cit111","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20220324"},{"key":"ref112\/cit112","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-016-1527-4"},{"key":"ref113\/cit113","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-018-0356-z"},{"key":"ref114\/cit114","doi-asserted-by":"publisher","DOI":"10.1039\/C5NR03474D"},{"key":"ref115\/cit115","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2016.08.052"},{"key":"ref116\/cit116","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01269-0"},{"key":"ref117\/cit117","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.05.030"},{"key":"ref118\/cit118","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.2c00240"},{"key":"ref119\/cit119","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.12.013"},{"key":"ref120\/cit120","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.09.029"},{"key":"ref121\/cit121","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.2c03065"},{"key":"ref122\/cit122","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.3c01078"},{"key":"ref123\/cit123","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2023.116951"},{"key":"ref124\/cit124","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-29901-5"},{"key":"ref125\/cit125","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c20334"},{"key":"ref126\/cit126","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2022.102601"},{"key":"ref127\/cit127","doi-asserted-by":"publisher","DOI":"10.1109\/TNB.2023.3267268"},{"key":"ref128\/cit128","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00461H"},{"key":"ref129\/cit129","doi-asserted-by":"publisher","DOI":"10.1016\/j.jab.2016.03.001"},{"key":"ref130\/cit130","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11762-0"},{"key":"ref131\/cit131","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.3c00239"},{"key":"ref132\/cit132","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.2c00007"},{"key":"ref133\/cit133","doi-asserted-by":"publisher","DOI":"10.2174\/1381612826666200218101231"},{"key":"ref134\/cit134","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2022.114485"},{"key":"ref135\/cit135","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15010221"},{"key":"ref136\/cit136","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.120479"},{"key":"ref137\/cit137","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2023.113270"},{"key":"ref138\/cit138","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15051399"},{"key":"ref139\/cit139","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000265401.62434.36"},{"key":"ref140\/cit140","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222413258"},{"key":"ref141\/cit141","unstructured":"Aphios. Study of APH-1105\nin Patients With Mild to Moderate Alzheimer\u2019s Disease, ICH\nGCP, 2021. https:\/\/ichgcp.net\/clinical-trials-registry\/NCT03806478 (accessed December 1, 2023)."},{"key":"ref142\/cit142","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2107454"},{"key":"ref143\/cit143","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14020398"},{"key":"ref144\/cit144","unstructured":"Alnylam Pharmaceuticals. The Study of an Investigational Drug, Patisiran\n(ALN-TTR02), for\nthe Treatment of Transthyretin (TTR)-Mediated Amyloidosis in Patients\nWho Have Already Been Treated With ALN-TTR02 (Patisiran), 2023; ClinicalTrials.Gov. https:\/\/clinicaltrials.gov\/study\/NCT02510261?tab=table (accessed\nDecember 1, 2023)."},{"key":"ref145\/cit145","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-022-03164-z"},{"key":"ref146\/cit146","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-021-01546-6"},{"key":"ref147\/cit147","doi-asserted-by":"publisher","DOI":"10.1007\/s40199-018-0221-5"},{"key":"ref148\/cit148","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2021.03.025"},{"key":"ref149\/cit149","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14102066"},{"key":"ref150\/cit150","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2014.11.005"},{"key":"ref151\/cit151","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.11.026"},{"key":"ref152\/cit152","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-014-0032-5"},{"key":"ref153\/cit153","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.03.010"},{"key":"ref154\/cit154","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04765-1"},{"key":"ref155\/cit155","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2022.102575"},{"key":"ref156\/cit156","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-018-0392-8"},{"key":"ref157\/cit157","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.04.036"},{"key":"ref158\/cit158","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202207719"},{"key":"ref159\/cit159","doi-asserted-by":"publisher","DOI":"10.3109\/02652048.2013.863395"},{"key":"ref160\/cit160","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X20666220706121412"},{"key":"ref161\/cit161","doi-asserted-by":"publisher","DOI":"10.1289\/EHP234"},{"key":"ref162\/cit162","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.2c03682"},{"key":"ref163\/cit163","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-019-09864-z"},{"key":"ref164\/cit164","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14546"},{"key":"ref165\/cit165","doi-asserted-by":"publisher","DOI":"10.1021\/nn4058215"},{"key":"ref166\/cit166","doi-asserted-by":"publisher","DOI":"10.7150\/thno.77243"},{"key":"ref167\/cit167","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.09.058"},{"key":"ref168\/cit168","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2015.07.003"},{"key":"ref169\/cit169","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21020493"},{"key":"ref170\/cit170","doi-asserted-by":"publisher","DOI":"10.2174\/1871520614666140521122932"},{"key":"ref171\/cit171","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00244"},{"key":"ref172\/cit172","doi-asserted-by":"publisher","DOI":"10.1055\/a-1509-5904"},{"key":"ref173\/cit173","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.12.024"},{"key":"ref174\/cit174","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2010.00147.x"},{"key":"ref175\/cit175","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.08.004"},{"key":"ref176\/cit176","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170188"},{"key":"ref177\/cit177","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.230303"},{"key":"ref178\/cit178","doi-asserted-by":"publisher","DOI":"10.3390\/ma14123332"},{"key":"ref179\/cit179","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2018.11.008"},{"key":"ref180\/cit180","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.117999"},{"key":"ref181\/cit181","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14091976"},{"key":"ref182\/cit182","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.01.015"},{"key":"ref183\/cit183","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.02.001"},{"key":"ref184\/cit184","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.35006"},{"key":"ref185\/cit185","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.327328"},{"key":"ref186\/cit186","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2021.2003656"},{"key":"ref187\/cit187","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8844455"},{"key":"ref188\/cit188","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202100746"},{"key":"ref189\/cit189","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c17823"},{"key":"ref190\/cit190","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2013.08.001"},{"key":"ref191\/cit191","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20944"},{"key":"ref192\/cit192","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.11.047"},{"key":"ref193\/cit193","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241310494"},{"key":"ref194\/cit194","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2016-0399"},{"key":"ref195\/cit195","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120160"},{"key":"ref196\/cit196","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-021-02706-x"},{"key":"ref197\/cit197","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2019.10.005"},{"key":"ref198\/cit198","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c17861"},{"key":"ref199\/cit199","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.123125"},{"key":"ref200\/cit200","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.576037"},{"key":"ref201\/cit201","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-022-01256-w"},{"key":"ref202\/cit202","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2018.11.001"},{"key":"ref203\/cit203","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2022.09.030"},{"key":"ref204\/cit204","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2022.110291"},{"key":"ref205\/cit205","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.3c01650"},{"key":"ref206\/cit206","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2016.10.008"},{"key":"ref207\/cit207","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S402447"},{"key":"ref208\/cit208","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2022.2072543"},{"key":"ref209\/cit209","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2023.104691"},{"key":"ref210\/cit210","doi-asserted-by":"publisher","DOI":"10.1080\/02652048.2023.2167011"},{"key":"ref211\/cit211","doi-asserted-by":"publisher","DOI":"10.7150\/thno.18219"},{"key":"ref212\/cit212","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b01994"},{"key":"ref213\/cit213","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S161940"},{"key":"ref214\/cit214","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.06.001"},{"key":"ref215\/cit215","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.327"},{"key":"ref216\/cit216","first-page":"1","volume-title":"Nanotechnol. Med. Toxic. Saf.","author":"Patel R.","year":"2021"},{"key":"ref217\/cit217","doi-asserted-by":"publisher","DOI":"10.1002\/9781119769897.ch7"},{"key":"ref218\/cit218","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-05144-0_8"},{"key":"ref219\/cit219","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.08.008"},{"key":"ref220\/cit220","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2020.102239"},{"key":"ref221\/cit221","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01481-w"},{"key":"ref222\/cit222","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.124316"},{"key":"ref223\/cit223","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c05795"},{"key":"ref224\/cit224","volume-title":"AAT-AD\/PD 2020 Conf. Adv. Alzheimer\u2019s Park. Ther.","author":"Rogers M. B.","year":"2020"},{"key":"ref225\/cit225","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202106072"},{"key":"ref226\/cit226","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202100746"},{"key":"ref227\/cit227","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241310494"},{"key":"ref228\/cit228","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2022.09.030"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.4c04887","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.4c04887","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T10:03:19Z","timestamp":1763460199000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.4c04887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,7]]},"references-count":228,"journal-issue":{"issue":"45","published-print":{"date-parts":[[2025,11,18]]}},"alternative-id":["10.1021\/acsomega.4c04887"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.4c04887","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"value":"2470-1343","type":"print"},{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,7]]}}}