{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:44:03Z","timestamp":1787921043324,"version":"build-2784847793"},"reference-count":92,"publisher":"American Chemical Society (ACS)","issue":"34","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda??o Carlos Chagas Filho de Amparo ? Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Programa de P?s Gradua??o em Ci?ncias e Biotecnologia da Universidade Federal Fluminense"},{"name":"Programa de P?s-gradua??o em Biologia Molecular e Celular da Universidade Federal do Estado do Rio de Janeiro"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2024,8,27]]},"DOI":"10.1021\/acsomega.4c05904","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T11:24:18Z","timestamp":1723807458000},"page":"36835-36846","source":"Crossref","is-referenced-by-count":4,"title":["Synthetic Naphthoquinone Inhibits Herpes Simplex Virus Type-1 Replication Targeting Na<sup>+<\/sup>, K<sup>+<\/sup> ATPase"],"prefix":"10.1021","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9767-8560","authenticated-orcid":true,"given":"Kau\u00ea Francisco Corr\u00eaa de Souza e","family":"Souza","sequence":"first","affiliation":[{"name":"Departamento de Biologia Celular e Molecular","place":["Niter\u00f3i, Brazil"]},{"name":"Instituto de Biologia, Universidade Federal Fluminense","place":["Niter\u00f3i, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor Won-Held","family":"Rabelo","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Celular e Molecular","place":["Niter\u00f3i, Brazil"]},{"name":"Instituto de Biologia, Universidade Federal Fluminense","place":["Niter\u00f3i, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Alvarez","family":"Abreu","sequence":"additional","affiliation":[{"name":"Instituto de Biodiversidade e Sustentabilidade","place":["Maca\u00e9, Brazil"]},{"name":"Universidade Federal do Rio de Janeiro","place":["Maca\u00e9, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udio C\u00e9sar Cirne","family":"Santos","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Celular e Molecular","place":["Niter\u00f3i, Brazil"]},{"name":"Instituto de Biologia, Universidade Federal Fluminense","place":["Niter\u00f3i, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayane Abreu do","family":"Amaral e Silva","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Instituto de Qu\u00edmica, Laborat\u00f3rio de Cat\u00e1lise e S\u00edntese (Lab CSI)","place":["Niter\u00f3i, Brazil"]},{"name":"Universidade Federal Fluminense","place":["Niter\u00f3i, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6657-040X","authenticated-orcid":true,"given":"Daniela","family":"de Luna Martins","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Instituto de Qu\u00edmica, Laborat\u00f3rio de Cat\u00e1lise e S\u00edntese (Lab CSI)","place":["Niter\u00f3i, Brazil"]},{"name":"Universidade Federal Fluminense","place":["Niter\u00f3i, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor Francisco","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Departamento de Tecnologia Farmac\u00eautica","place":["Niter\u00f3i, Brazil"]},{"name":"Universidade Federal Fluminense, Faculdade de Farm\u00e1cia","place":["Niter\u00f3i, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo Ferreira","family":"Braz","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Anal\u00edtica, Instituto de Qu\u00edmica","place":["Rio de Janeiro, Brazil"]},{"name":"Universidade Federal do Rio de Janeiro","place":["Rio de Janeiro, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Erthal","family":"Santelli","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Anal\u00edtica, Instituto de Qu\u00edmica","place":["Rio de Janeiro, Brazil"]},{"name":"Universidade Federal do Rio de Janeiro","place":["Rio de Janeiro, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassiano Felippe","family":"Gon\u00e7alves-de-Albuquerque","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunofarmacologia","place":["Rio de Janeiro, Brazil"]},{"name":"Instituto Oswaldo Cruz, FIOCRUZ","place":["Rio de Janeiro, Brazil"]},{"name":"Laborat\u00f3rio de Imunofarmacologia","place":["Rio de Janeiro, Brazil"]},{"name":"Universidade Federal do Estado do Rio de Janeiro","place":["Rio de Janeiro, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabel Christina Nunes de Palmer","family":"Paix\u00e3o","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Celular e Molecular","place":["Niter\u00f3i, Brazil"]},{"name":"Instituto de Biologia, Universidade Federal Fluminense","place":["Niter\u00f3i, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Burth","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Celular e Molecular","place":["Niter\u00f3i, Brazil"]},{"name":"Instituto de Biologia, Universidade Federal Fluminense","place":["Niter\u00f3i, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04638-9"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.19.237149"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198603133141105"},{"key":"ref4\/cit4","first-page":"1","volume-title":"Introdu\u00e7\u00e3o \u00e0 virologia humana","author":"de Oliveira Santos N. S.","year":"2008","edition":"2"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-019-1285-x"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00048"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03252-3"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2003.09.006"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000554"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2016.01.013"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(77)80110-5"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(79)90177-6"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.24.2.273"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00693-16"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00707.2004"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/bi002069p"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.67.2591"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-006-0824-x"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00770-07"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2007.05.001"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2008.01.156"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2011.06.015"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19082154"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2008.05.008"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2813253"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2001899"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2008.01.156"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-40422009000300012"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0246811"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1573(200102)15:1<44::AID-PTR685>3.0.CO;2-1"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2012.06.027"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.catena.2013.03.018"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/np9601871"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.04.075"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1007\/s10600-012-0094-7"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.21577\/0103-5053.20220010"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh136"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1039\/C6NJ00872K"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.10.033"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(02)00077-3"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty707"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btx491"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(00)00129-0"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/jm701122q"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.07.071"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00104"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1078\/094471103322331467"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(02)00054-2"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.49.3.980-983.1984"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1089\/adt.2004.2.535"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1993.1626"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/nature12578"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0907054106"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889892009944"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1038\/356083a0"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm290"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.2174\/1389450115666140908125025"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-3-33"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21256"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24071279"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1007\/s00894-014-2322-5"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1021\/ci300112j"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1017\/S0033583515000190"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2010.02.318"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.3851\/IMP3039"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2004.02.009"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26185627"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.63.11.4882-4889.1989"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.68.8.4898-4909.1994"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2004.08.013"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-967109"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.2174\/187152607780090766"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-70-12-3493"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-75-12-3337"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2018.07.028"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2017.04.017"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2011.06.015"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1021\/bi00668a001"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(89)90168-9"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1007\/BF00566166"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1124\/mol.110.063974"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00371"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1038\/nature09309"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115475"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.3109\/14756369109069071"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)70062-3"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03252-3"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfr345"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-72-3-541"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-60-2-199"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-011-0058-x"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(77)90120-3"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.4c05904","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.4c05904","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T18:29:27Z","timestamp":1741631367000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.4c05904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,16]]},"references-count":92,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2024,8,27]]}},"alternative-id":["10.1021\/acsomega.4c05904"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.4c05904","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"value":"2470-1343","type":"print"},{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,16]]}}}