{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T23:44:37Z","timestamp":1793403877578,"version":"4.5.0"},"reference-count":43,"publisher":"American Chemical Society (ACS)","issue":"12","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["02(0318)\/17\/EMR-II"],"award-info":[{"award-number":["02(0318)\/17\/EMR-II"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001839","name":"University Grants Committee","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001839","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","award":["58-6408-2-0009"],"award-info":[{"award-number":["58-6408-2-0009"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2025,4,1]]},"DOI":"10.1021\/acsomega.4c08363","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T17:55:36Z","timestamp":1742234136000},"page":"11873-11886","source":"Crossref","is-referenced-by-count":6,"title":["Aminoquinoline-Pyrimidine-Based Alkyl-Piperazine Tethered Hybrids: Synthesis, Antiplasmodial Activity, and Mechanistic Studies"],"prefix":"10.1021","volume":"10","author":[{"given":"Srishti","family":"Rawat","sequence":"first","affiliation":[{"name":"Department of Chemistry","place":["Delhi, India"]},{"name":"University of Delhi","place":["Delhi, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuj","family":"Thakur","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Delhi, India"]},{"name":"University of Delhi","place":["Delhi, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6429-7219","authenticated-orcid":true,"given":"Shabana I.","family":"Khan","sequence":"additional","affiliation":[{"name":"National Centre for Natural Products Research","place":["Oxford, United States"]},{"name":"University of Mississippi","place":["Oxford, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Kholiya","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Delhi, India"]},{"name":"University of Delhi","place":["Delhi, India"]},{"name":"Department of Chemistry","place":["Delhi, India"]},{"name":"Deshbandhu College, University of Delhi","place":["Delhi, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babu L.","family":"Tekwani","sequence":"additional","affiliation":[{"name":"National Centre for Natural Products Research","place":["Oxford, United States"]},{"name":"University of Mississippi","place":["Oxford, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Bahuguna","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Delhi, India"]},{"name":"University of Delhi","place":["Delhi, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5473-7476","authenticated-orcid":true,"given":"Diwan S.","family":"Rawat","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Delhi, India"]},{"name":"University of Delhi","place":["Delhi, India"]},{"name":"Kumaun University Nainital","place":["Nainital, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,3,17]]},"reference":[{"key":"ref1\/cit1","unstructured":"The History of Malaria,\nAn Ancient Disease, 2017. http:\/\/www.cdc.gov\/malaria\/about\/history"},{"key":"ref2\/cit2","volume-title":"World malaria report 2023","author":"WHO","year":"2023"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1946.02870160015006"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-019-2724-z"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199345030-00009"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)92371-8"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.292.6522.721"},{"key":"ref8\/cit8","unstructured":"https:\/\/www.who.int\/malaria\/areas\/treatment\/overview\/en\/ (accessed 12 November 2023)."},{"key":"ref9\/cit9","unstructured":"https:\/\/www.malariaconsortium.org\/pages\/112.htm (accessed 12 November 2023)."},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4573"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314981"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0805011"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808859"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/cr500098f"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/cr500123g"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/ar7000843"},{"key":"ref17\/cit17a","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2007.03.007"},{"key":"ref17\/cit17b","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.15.128"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.04.017"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/ml3000808"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.11.021"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39970-9"},{"key":"ref22\/cit22","unstructured":"https:\/\/www.wsj.com\/articles\/hanall-biopharma-daewoong-pharmaceutical-and-nurron-pharmaceuticals-initiate-first-in-human-phase-1-clinical-study-of-hl192-961063de?reflink=desktopwebshare_permalink."},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA02276A"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/jm200149e"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.2741\/s344"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(96)00152-X"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00288-07"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4165(00)00058-1"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-0134(01)00217-3"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpc.2011.03.008"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.161"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4381"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/nsb921"},{"key":"ref34\/cit34","unstructured":"Schr\u00f6dinger,\nLLC.  QikProp, version\n3.5; Schr\u00f6dinger, LLC: New York, NY, 2012."},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2014.08.013"},{"key":"ref36\/cit36","unstructured":"Schr\u00f6dinger,\nLLC.  QikProp User Manual; Schr\u00f6dinger, LLC, 2013."},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/jm0306529"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/jm060399n"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2009.05.075"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2005.04.034"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1993.48.205"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1007\/BF02624436"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.4c08363","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.4c08363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T19:04:43Z","timestamp":1743534283000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.4c08363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,17]]},"references-count":43,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,4,1]]}},"alternative-id":["10.1021\/acsomega.4c08363"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.4c08363","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"value":"2470-1343","type":"print"},{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,17]]}}}