{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:57:38Z","timestamp":1789966658754,"version":"4.0.1"},"reference-count":76,"publisher":"American Chemical Society (ACS)","issue":"39","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Lu'an Science and Technology Project","award":["2024lakj009"],"award-info":[{"award-number":["2024lakj009"]}]},{"name":"Lu'an Science and Technology Project","award":["2024lakj012"],"award-info":[{"award-number":["2024lakj012"]}]},{"name":"Anhui Provincial Key Clinical Specialty Construction Project"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2025,10,7]]},"DOI":"10.1021\/acsomega.4c10672","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T07:51:43Z","timestamp":1758786703000},"page":"44869-44884","source":"Crossref","is-referenced-by-count":1,"title":["Identification of CYP2B6 as a Novel Biomarker of HRD in Colon Adenocarcinoma through WGCNA and Machine Learning"],"prefix":"10.1021","volume":"10","author":[{"given":"Xuemei","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Gastroenterology","place":["Lu\u2019an, China"]},{"name":"Lu\u2019an People\u2019s Hospital","place":["Lu\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahu","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of General Surgery","place":["Lu\u2019an, China"]},{"name":"Lu\u2019an People\u2019s Hospital","place":["Lu\u2019an, China"]},{"name":"Department of General Surgery","place":["Hefei, China"]},{"name":"The First Affiliated Hospital of Anhui Medical University","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizhen","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pediatric internal medicine","place":["Lu\u2019an, China"]},{"name":"Lu\u2019an People\u2019s Hospital","place":["Lu\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2235-1889","authenticated-orcid":true,"given":"Changjun","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of General Surgery","place":["Hefei, China"]},{"name":"The First Affiliated Hospital of Anhui Medical University","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of General Surgery","place":["Hefei, China"]},{"name":"The First Affiliated Hospital of Anhui Medical University","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-64308-w"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-46675-y"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-024-03491-2"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1186\/s13690-024-01463-6"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202267"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-022-02534-0"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1111\/gtc.13017"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12467"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2023.503703"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2022.100049"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/onco.13829"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0390-2"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2021.01.002"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2021-0072"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad723"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.48"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-00297-8"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.03.076"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105644"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.934083"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.3390\/genes10090697"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2023.04.020"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14133"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.08.2102"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam7344"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23463-8"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.02.052"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1193"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-559"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-23730-8"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2023.2174339"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2023.2293594"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jip.2025.108326"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1186\/s12920-025-02129-0"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-025-03755-5"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09234-6"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-017-1349-1"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1111\/exd.15070"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111874"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1002\/tox.24123"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq170"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107468"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1111"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac394"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.235"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac956"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7788.76794"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2024.108367"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S227033"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1172\/JCI178278"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.880643"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01227-0"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.4.1566"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.18.2412"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.121938"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-023-04776-1"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-023-02734-2"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.1012193"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2166"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2016.07.016"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.040507"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12783"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.jcrt_294_22"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1080\/00498254.2020.1737759"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-014-2632-4"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-024-01954-y"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1200\/PO.22.00258"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-23-0628"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00558"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0511218"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1093\/jleuko\/qiad123"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14781"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147260"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109016"},{"key":"ref76\/cit76","first-page":"1413","volume":"25","author":"Xu M.","year":"2020","journal-title":"J. Balkan Union Oncol."}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.4c10672","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.4c10672","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T08:14:30Z","timestamp":1759824870000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.4c10672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,25]]},"references-count":76,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2025,10,7]]}},"alternative-id":["10.1021\/acsomega.4c10672"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.4c10672","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"value":"2470-1343","type":"print"},{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,25]]}}}