{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:23:27Z","timestamp":1788884607265,"version":"build-2803163510"},"reference-count":90,"publisher":"American Chemical Society (ACS)","issue":"27","license":[{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006464","name":"Birla Institute of Technology and Science, Pilani","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006464","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Exploring the design and synthesis of new antibiotic compounds is important to treat multidrug-resistant bacterial infections for the already exposed drug molecules. In this work, a phenanthroline derivative, namely, 6-[2-(ethoxycarbonyl)\u00addiazen-1-yl]-1,10-phenanthroline-5-one (ECDPO), and its mono- and bis-ligand silver complexes [Ag\u00ad(ECDPO)\u00ad(NO3)] and [Ag\u00ad(ECDPO)2]\u00ad(NO3) were synthesized. Single-crystal X-ray diffraction (XRD) structure of methanol-solvated ECDPO was studied, which crystallized in a monoclinic system, P21\/n space group. ECDPO is a planar molecule, and supramolecular arrays are stabilized by various hydrogen bonding, namely, O\u2013H\u00b7\u00b7\u00b7N, N\u2013H\u00b7\u00b7\u00b7O, and C\u2013H\u00b7\u00b7\u00b7O, and \u03c0\u2013\u03c0 interactions. The spectroscopic features of ECDPO and its silver complexes were thoroughly studied by high-resolution mass spectrometry (HRMS), IR, 1H NMR, 13C NMR, UV\u2013visible spectroscopy, and X-ray photoelectron spectroscopy (XPS). Electrochemical redox features were studied by cyclic voltammetry. The ECDPO molecule and its silver complexes were studied for antibacterial activity against Escherichia coli bacteria and Mycobacterium tuberculosis (Mtb). ECDPO shows a minimum inhibitory concentration (MIC) of 1.56 \u03bcg\/mL against Mtb, which is comparable to that of one of the clinically used drug candidates, namely, ethambutol. Silver complexes [Ag\u00ad(ECDPO)\u00ad(NO3)] and [Ag\u00ad(ECDPO)2]\u00ad(NO3) showed enhanced anti-TB activities and MICs of 0.78 and 0.39 \u03bcg\/mL, respectively.<\/jats:p>","DOI":"10.1021\/acsomega.5c00871","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T16:50:47Z","timestamp":1749833447000},"page":"28993-29013","source":"Crossref","is-referenced-by-count":7,"title":["Synthesis, Characterization,\nand Anti-\n                    <i>TB<\/i>\n                    Application of Redox-Active Ethyl Carbazate-Derivatized\nPhenanthroline\nand Its Silver Complexes"],"prefix":"10.1021","volume":"10","author":[{"given":"Ravallika","family":"Aluri","sequence":"first","affiliation":[{"name":"Birla Institute of Technology and Science, Pilani, Hyderabad Campus , , Jawahar Nagar , , ,","place":["Hyderabad, Telangana, India, 500 078"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aishwarya","family":"Natarajan","sequence":"additional","affiliation":[{"name":"Birla Institute of Technology and Science, Pilani, Hyderabad Campus , , Jawahar Nagar , , ,","place":["Hyderabad, Telangana, India, 500 078"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyothi","family":"Kumari","sequence":"additional","affiliation":[{"name":"Birla Institute of Technology and Science, Pilani, Hyderabad Campus , , Jawahar Nagar , , ,","place":["Hyderabad, Telangana, India, 500 078"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharmarajan","family":"Sriram","sequence":"additional","affiliation":[{"name":"Birla Institute of Technology and Science, Pilani, Hyderabad Campus , , Jawahar Nagar , , ,","place":["Hyderabad, Telangana, India, 500 078"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pralok K.","family":"Samanta","sequence":"additional","affiliation":[{"name":"Birla Institute of Technology and Science, Pilani, Hyderabad Campus , , Jawahar Nagar , , ,","place":["Hyderabad, Telangana, India, 500 078"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1951-8462","authenticated-orcid":true,"given":"Aditi","family":"Gangopadhyay","sequence":"additional","affiliation":[{"name":"University of Calcutta , , 92 APC Road , , ,","place":["Kolkata, West\nBengal, India, 700009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0518-8431","authenticated-orcid":true,"given":"Krishnan","family":"Rangan","sequence":"additional","affiliation":[{"name":"Birla Institute of Technology and Science, Pilani, Hyderabad Campus , , Jawahar Nagar , , ,","place":["Hyderabad, Telangana, India, 500 078"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,6,13]]},"reference":[{"key":"2026081812102861800_cit1","unstructured":"King, A.\n          \n          Antimicrobial\nResistance Will Kill 300 Million by 2050 without Action, Chem. World., 2014http:\/\/www.rsc.org\/chemistryworld\/2014\/12\/antimicrobialresistance-will-kill-300-million-2050-without-action."},{"key":"2026081812102861800_cit2","unstructured":"World Health Statistics\n          \n          Monitoring health for the SDGs, Sustainable Development\nGoals\n          2024\n          https:\/\/www.who.int\/publications\/i\/item\/9789240094703."},{"key":"2026081812102861800_cit3","unstructured":"Global Tuberculosis Report; World Health\nOrganization, 2023. https:\/\/www.who.int\/teams\/global-tuberculosis-programme\/tb-reports\/global-tuberculosis-report2023#;~;text=The%20WHO%20Global%20Tuberculosis%20Report,global%2C%20regional%20and%20country%20levelshttps:\/\/www.who.int\/teams\/global-tuberculosis-programme\/tb-reports\/global-tuberculosis-report2023#;~;text=The%20WHO%20Global%20Tuberculosis%20Report,global%2C%20regional%20and%20country%20levels."},{"key":"2026081812102861800_cit4","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1016\/S2214-109X(17)30203-6","article-title":"Financing\nof international collective action for epidemic and pandemic preparedness","volume":"5","author":"Yamey","year":"2017","journal-title":"Lancet Global Health"},{"key":"2026081812102861800_cit5","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1002\/cpt.2261","article-title":"The treatment of\ntuberculosis","volume":"110","author":"Peloquin","year":"2021","journal-title":"Clin. Pharmacol. Ther."},{"key":"2026081812102861800_cit6","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.addr.2014.08.004","article-title":"Metal nanobullets\nfor multidrug resistant bacteria\nand biofilms","volume":"78","author":"Chen","year":"2014","journal-title":"Adv. Drug Delivery Rev."},{"key":"2026081812102861800_cit7","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/nrd940","article-title":"The future challenges facing the\ndevelopment of new antimicrobial drugs","volume":"1","author":"Coates","year":"2002","journal-title":"Nat.\nRev. Drug Discovery"},{"key":"2026081812102861800_cit8","unstructured":"World Health Organization\n          \n          Antibacterial agents in clinical and preclinical development; an\noverview and analysis\n          2023\n          https:\/\/www.who.int\/publications\/i\/item\/9789240094000."},{"key":"2026081812102861800_cit9","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1021\/acsinfecdis.0c00331","article-title":"Antibiotics\nspecial issue; challenges and opportunities in antibiotic discovery\nand development","volume":"6","author":"Blaskovich","year":"2020","journal-title":"ACS Infect. Dis."},{"key":"2026081812102861800_cit10","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1021\/acsinfecdis.0c00044","article-title":"The antibacterial research\nand development pipeline\nneeds urgent solutions","volume":"6","author":"Beyer","year":"2020","journal-title":"ACS Infect. 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Rev."},{"key":"2026081812102861800_cit12","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1159\/000159989","article-title":"Action tuberculostati\u0301que\nde l\u2019o-Phe\u0301nanthroline","volume":"14","author":"Turian","year":"1951","journal-title":"Pathobiology"},{"key":"2026081812102861800_cit13","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.molstruc.2010.05.031","article-title":"Synthesis, spectral\ninvestigations, antimicrobial activity and DNA-binding\nstudies of novel charge transfer complex of 1, 10-phenanthroline as\nan electron donor with \u03c0-acceptor p-nitrophenol","volume":"977","author":"Khan","year":"2010","journal-title":"J. Mol. Struct."},{"key":"2026081812102861800_cit14","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1128\/AAC.00969-17","article-title":"Dual mechanism of action\nof 5-nitro-1, 10-phenanthroline against Mycobacterium tuberculosis","volume":"61","author":"Kidwai","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"2026081812102861800_cit15","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.2174\/092986712800609733","article-title":"Deciphering\nthe antimicrobial activity of phenanthroline chelators","volume":"19","author":"McCann","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"2026081812102861800_cit16","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1002\/cmdc.200800097","article-title":"Phenanthroline derivatives with improved\nselectivity as DNA-targeting anticancer or antimicrobial drugs","volume":"3","author":"Roy","year":"2008","journal-title":"ChemMedChem"},{"key":"2026081812102861800_cit17","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1093\/jac\/dkv292","article-title":"Anti-Pseudomonas\naeruginosa activity of 1, 10-phenanthroline-based drugs against both\nplanktonic-and biofilm-growing cells","volume":"71","author":"Viganor","year":"2016","journal-title":"J. Antimicrob.\nChemother."},{"key":"2026081812102861800_cit18","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/S0020-1693(01)00711-3","article-title":"1, 10-Phenanthroline-5,6-dione as\na building block for the synthesis of homo-and heterometallic complexes","volume":"330","author":"Calderazzo","year":"2002","journal-title":"Inorg. Chim. Acta"},{"key":"2026081812102861800_cit19","doi-asserted-by":"publisher","first-page":"3911","DOI":"10.1016\/j.ica.2006.04.040","article-title":"Transition\nmetal derivatives of 1, 10-phenanthroline-5, 6-dione: Controlled growth\nof coordination polynuclear derivatives","volume":"359","author":"Calucci","year":"2006","journal-title":"Inorg.\nChim. Acta"},{"key":"2026081812102861800_cit20","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1039\/c2tx00010e","article-title":"In vitro and\nin vivo studies into the biological activities of 1, 10-phenanthroline,\n1,10-phenanthroline-5,6-dione and its copper\u00ad(II) and silver\u00ad(I) complexes","volume":"1","author":"McCann","year":"2012","journal-title":"Toxicol. Res."},{"key":"2026081812102861800_cit21","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.cbi.2006.08.025","article-title":"In vitro\nanti-tumour effect of 1, 10-phenanthroline-5,6-dione (phendione),\n[Cu\u00ad(phendione)3]\u00ad(ClO4)2\u00b74H2O and [Ag\u00ad(phendione)2]\u00adClO4 using human\nepithelial cell lines","volume":"164","author":"Deegan","year":"2006","journal-title":"Chem.-Biol. Interact."},{"key":"2026081812102861800_cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175120","article-title":"Synthesis and anticancer\nevaluations of novel 1H-imidazole\u00ad[4,5-f]\u00ad[1,10]\nphenanthroline derivative for the treatment of colorectal cancer","volume":"928","author":"Hu","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"2026081812102861800_cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2022.105851","article-title":"1H-imidazo\u00ad[4,5-f]\u00ad[1,10]\u00adphenanthroline\ncarbohydrate conjugates; synthesis, DNA interactions and cytotoxic\nactivity","volume":"125","author":"Vin\u0303uales","year":"2022","journal-title":"Bioorg. Chem."},{"key":"2026081812102861800_cit24","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s10534-021-00358-1","article-title":"Synthesis\nand characterisation\nof phenanthroline-oxazine ligands and their Ag\u00ad(I), Mn\u00ad(II) and Cu\u00ad(II)\ncomplexes and their evaluation as antibacterial agents","volume":"35","author":"Ahmed","year":"2022","journal-title":"BioMetals"},{"key":"2026081812102861800_cit25","doi-asserted-by":"publisher","first-page":"69","DOI":"10.4103\/0975-7406.129170","article-title":"A review exploring\nbiological activities of hydrazones","volume":"6","author":"Verma","year":"2014","journal-title":"J. Pharm.\nBioAllied Sci."},{"key":"2026081812102861800_cit26","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/s00044-016-1756-y","article-title":"Hydrazide\u2013hydrazones\nas potential antimicrobial agents; overview of the literature since\n2010","volume":"26","author":"Popio\u0142ek","year":"2017","journal-title":"Med. Chem. Res."},{"key":"2026081812102861800_cit27","doi-asserted-by":"publisher","first-page":"277","DOI":"10.2478\/acph-2019-0020","article-title":"Antimicrobial assesment of aroylhydrazone derivatives\nin vitro","volume":"69","author":"Polovic\u0301","year":"2019","journal-title":"Acta Pharm."},{"key":"2026081812102861800_cit28","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.molstruc.2011.12.023","article-title":"Synthesis, characterization and anticancer evaluation\nof novel tri-arm star shaped 1, 3, 5-triazine hydrazones","volume":"1011","author":"Machakanur","year":"2012","journal-title":"J. Mol. Struct."},{"key":"2026081812102861800_cit29","doi-asserted-by":"publisher","first-page":"45","DOI":"10.21608\/jabps.2020.21160.1064","article-title":"Novel Benzimidazole\/Hydrazone\nDerivatives\nas Promising Anticancer Lead Compounds; Design, Synthesis, and Molecular\nDocking Study","volume":"0","author":"Morcoss","year":"2020","journal-title":"J. Adv. Biomed. Pharm. Sci."},{"key":"2026081812102861800_cit30","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1080\/13510002.2016.1276256","article-title":"3-methoxy\naroylhydrazones\u2013free radicals scavenging,\nanticancer and cytoprotective potency","volume":"22","author":"Hristova-Avakumova","year":"2017","journal-title":"Redox\nRep."},{"key":"2026081812102861800_cit31","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1111\/cbdd.12684","article-title":"A note on derivatives of isoniazid,\nRifampicin, and pyrazinamide showing activity against resistant Mycobacterium\ntuberculosis","volume":"87","author":"Unissa","year":"2016","journal-title":"Chem. Biol. Drug Des."},{"key":"2026081812102861800_cit32","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.tube.2016.09.025","article-title":"Characterization\nof 2-hydroxy-1-naphthaldehyde isonicotinoyl\nhydrazone as a novel inhibitor of methionine aminopeptidases from\nMycobacterium tuberculosis","volume":"101","author":"John","year":"2016","journal-title":"Tuberculosis"},{"key":"2026081812102861800_cit33","doi-asserted-by":"publisher","first-page":"4313","DOI":"10.1016\/j.bmcl.2010.06.096","article-title":"5-Nitro-2-furoic\nacid hydrazones;\ndesign, synthesis and in vitro antimycobacterial evaluation against\nlog and starved phase cultures","volume":"20","author":"Sriram","year":"2010","journal-title":"Bioorg. Med.\nChem. Lett."},{"key":"2026081812102861800_cit34","doi-asserted-by":"publisher","first-page":"587","DOI":"10.2217\/fmb-2018-0357","article-title":"Novel 4-methoxynaphthalene-N-acylhydrazones\nas potential for paracoccidioidomycosis and tuberculosis co-infection","volume":"14","author":"Rozada","year":"2019","journal-title":"Future Microbiol."},{"key":"2026081812102861800_cit35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/07391102.2024.2319678","article-title":"In silico design, synthesis and antitubercular activity\nof novel 2-acylhydrazono-5-arylmethylene-4-thiazolidinones as enoyl-acyl\ncarrier protein reductase inhibitors","author":"Birgu\u0308l","year":"2024","journal-title":"J. Biomol.\nStruct. Dyn."},{"key":"2026081812102861800_cit36","doi-asserted-by":"publisher","first-page":"9731","DOI":"10.1021\/acsomega.1c00369","article-title":"Synthesis\nand biological evaluation\nof novel benzhydrylpiperazine-coupled nitrobenzenesulfonamide hybrids","volume":"6","author":"Murthy","year":"2021","journal-title":"ACS Omega"},{"key":"2026081812102861800_cit37","doi-asserted-by":"publisher","first-page":"3889","DOI":"10.1128\/AAC.00266-11","article-title":"Novel inhibitors\nof InhA efficiently kill Mycobacterium tuberculosis under aerobic\nand anaerobic conditions","volume":"55","author":"Vilche\u0300ze","year":"2011","journal-title":"Antimicrob. Agents\nChemother."},{"key":"2026081812102861800_cit38","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.ica.2017.11.015","article-title":"Cu\u00ad(II) complexes with hydrazone-functionalized\nphenanthrolines as self-activating metallonucleases","volume":"481","author":"Heinrich","year":"2018","journal-title":"Inorg. Chim. Acta"},{"key":"2026081812102861800_cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2020.112876","article-title":"Evaluating the anticancer properties\nand real-time\nelectrochemical extracellular bio-speciation of bis\u00ad(1,10-phenanthroline)\nsilver\u00ad(I) acetate monohydrate in the presence of A549 lung cancer\ncells","volume":"175","author":"Sidambaram","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"2026081812102861800_cit40","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1007\/s10534-019-00204-5","article-title":"Synthesis\nand antimicrobial activity\nof a phenanthroline-isoniazid hybrid ligand and its Ag+ and Mn2+ complexes","volume":"32","author":"Ahmed","year":"2019","journal-title":"BioMetals"},{"key":"2026081812102861800_cit41","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.ejmech.2017.04.002","article-title":"Isoniazid\nderivatives\nand their anti-tubercular activity","volume":"133","author":"Hu","year":"2017","journal-title":"Eur. J.\nMed. Chem."},{"key":"2026081812102861800_cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.140729","article-title":"Synthesis, characterisation,\nsingle crystal structure and evaluation of a redox innocent carbazate\nfunctionalized phenanthroline for antimycobacterial and anticancer\nactivity","volume":"1323","author":"Aluri","year":"2025","journal-title":"J. Mol. Struct."},{"key":"2026081812102861800_cit43","doi-asserted-by":"publisher","first-page":"5499","DOI":"10.1080\/07391102.2022.2090437","article-title":"A pair\nof carbazate derivatives as\nnovel Schiff base ligands; DFT and POM theory supported spectroscopic\nand biological evaluation","volume":"41","author":"Majid","year":"2023","journal-title":"J. Biomol. Struct.\nDyn."},{"key":"2026081812102861800_cit44","doi-asserted-by":"publisher","first-page":"44742","DOI":"10.1039\/C5RA04964D","article-title":"A bluish-green\nemitting organic compound methyl 3-[(E)-(2-hydroxy-1-naphthyl) methylidene]\ncarbazate; spectroscopic, thermal, fluorescence, antimicrobial and\nmolecular docking studies","volume":"5","author":"Gomathi","year":"2015","journal-title":"RSC Adv."},{"key":"2026081812102861800_cit45","doi-asserted-by":"publisher","first-page":"73","DOI":"10.4236\/ijoc.2013.33A008","article-title":"Biological\nactivities of Schiff bases and their complexes; a review of recent\nworks","volume":"03","author":"Zoubi","year":"2013","journal-title":"Int. J. Org. Chem."},{"key":"2026081812102861800_cit46","doi-asserted-by":"publisher","first-page":"10426","DOI":"10.1039\/D4DT00822G","article-title":"Coinage metal-ethylene\ncomplexes\nof sterically demanding 1, 10-phenanthroline ligands","volume":"53","author":"Karade","year":"2024","journal-title":"Dalton Trans."},{"key":"2026081812102861800_cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2023.102347","article-title":"Recent advances in\nthe development of metal complexes as antibacterial agents with metal-specific\nmodes of action","volume":"75","author":"Waters","year":"2023","journal-title":"Curr. Opin. Microbiol."},{"issue":"4","key":"2026081812102861800_cit48","doi-asserted-by":"publisher","first-page":"624","DOI":"10.2174\/0929867324666170920125943","article-title":"Ag+ complexes as potential\ntherapeutic agents in medicine and pharmacy","volume":"26","author":"Hecel","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"2026081812102861800_cit49","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1016\/j.biotechadv.2018.05.004","article-title":"Silver\nbullets; A new lustre on an old antimicrobial agent","volume":"36","author":"Mo\u0308hler","year":"2018","journal-title":"Biotechnol. Adv."},{"key":"2026081812102861800_cit50","doi-asserted-by":"publisher","first-page":"10880","DOI":"10.1039\/D0DT01272F","article-title":"Dinuclear\nsilver\u00ad(I) complexes with a pyridine-based macrocyclic type of ligand\nas antimicrobial agents against clinically relevant species; the influence\nof the counteranion on the structure diversification of the complexes","volume":"49","author":"Savic\u0301","year":"2020","journal-title":"Dalton Trans."},{"key":"2026081812102861800_cit51","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1007\/s10534-023-00513-w","article-title":"Synthesis, characterisation,\nand solution behaviour of Ag\u00ad(I) bis(phenanthroline-oxazine)\ncomplexes and the evaluation of their biological activity against\nthe pathogenic yeast Candida albicans","volume":"36","author":"Evans","year":"2023","journal-title":"BioMetals"},{"key":"2026081812102861800_cit52","doi-asserted-by":"publisher","first-page":"624","DOI":"10.2174\/0929867324666170920125943","article-title":"Ag+ complexes as potential\ntherapeutic agents in medicine and pharmacy","volume":"26","author":"Hecel","year":"2019","journal-title":"Curr. 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