{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T17:25:44Z","timestamp":1787073944450,"version":"build-2736575974"},"reference-count":59,"publisher":"American Chemical Society (ACS)","issue":"26","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of??Hunan Province","doi-asserted-by":"publisher","award":["2025JJ80932"],"award-info":[{"award-number":["2025JJ80932"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of??Hunan Province","doi-asserted-by":"publisher","award":["2025JJ81079"],"award-info":[{"award-number":["2025JJ81079"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81760345"],"award-info":[{"award-number":["81760345"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hainan Province","award":["HnkyJJ2021ZD-16"],"award-info":[{"award-number":["HnkyJJ2021ZD-16"]}]},{"name":"Hainan Province","award":["WSJK2024MS152"],"award-info":[{"award-number":["WSJK2024MS152"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Our previous study has confirmed that resveratrol (Res) can suppress hypertrophic scar through a variety of mechanisms, such as autophagy inhibition, apoptosis induction, and oxidative stress reduction. However, the primary obstacle to the pharmaceutical use of Res is its poor bioavailability. Here, an injectable and temperature-responsive hydrogel containing mesoporous silica nanoparticles loaded with Res (MSN@Res) was employed for the repair of hypertrophic scars, formulated by fine-tuning the combination of aldehyde-functionalized Pluronic F127 (F127-CHO, FC) and hyaluronic acid modified with adipic dihydrazide (AHA). This hybrid hydrogel exhibited suitable porosity, robust mechanical characteristics, and sustained release capability for Res. In vitro cellular tests indicated that the 8%FC\/AHA hydrogel possesses minimal cytotoxicity and excellent biocompatibility. Additionally, the 8%FC\/AHA-MSN@Res hydrogel showed nearly full antiproliferative activity against hypertrophic scar fibroblasts. The 8%FC\/AHA-MSN@Res hydrogel was subsequently applied to treat hypertrophic scars in the rat tails. The findings indicated that this composite hydrogel significantly improved the overall results, diminished the thickness of both the epidermis and dermis, and reduced the scar size. In addition, the hydrogel could suppress oxidative stress, downregulate the expression of p38-MAPK, HIF-1\u03b1, p53, and LC3-II, and upregulate caspase-3 expression in hypertrophic scars, which indicated that the composite hydrogel inhibits cellular autophagy, induces apoptosis of fibroblasts in hypertrophic scars, and then reduces the cell viability and collagen deposition, finally resulting in an acceleration of scar regression. This research validated that this composite hydrogel has the potential to serve as a highly effective therapeutic approach with promising prospects for clinical application in the treatment of hypertrophic scars.<\/jats:p>","DOI":"10.1021\/acsomega.5c01469","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T13:10:16Z","timestamp":1750943416000},"page":"27945-27963","source":"Crossref","is-referenced-by-count":3,"title":["Injectable Thermosensitive Hydrogel Containing Resveratrol-Laden\nNanoparticles Promotes Hypertrophic Scar Repair in Rat Tail"],"prefix":"10.1021","volume":"10","author":[{"given":"Jun","family":"Zuo","sequence":"first","affiliation":[{"name":"The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China , , ,","place":["HengYang, China, 421001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haigang","family":"Feng","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, Hengyang Medical School, University of South China , , ,","place":["HengYang, China, 421001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, Hengyang Medical School, University of South China , , ,","place":["HengYang, China, 421001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongju","family":"Xie","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Hainan Medical University , , ,","place":["HaiKou, China, 570100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaolin","family":"Ma","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Xinjiang Medical University , , ,","place":["Urumqi, China, 830000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8923-2498","authenticated-orcid":true,"given":"Fei","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Hospital of Hunan University of Chinese Medicine , , ,","place":["Changsha, China, 410000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"issue":"1","key":"2026081812071277600_cit1","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1186\/s13287-021-02290-0","article-title":"Exosomes derived from\nhuman adipose mesenchymal stem cells attenuate hypertrophic scar fibrosis\nby miR-192\u20135p\/IL-17RA\/Smad axis","volume":"12","author":"Li","year":"2021","journal-title":"Stem\nCell Res. 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Drug Delivery Rev."},{"issue":"8","key":"2026081812071277600_cit4","doi-asserted-by":"publisher","first-page":"2400","DOI":"10.1016\/j.bioactmat.2021.01.014","article-title":"Bilayer dissolving microneedle\narray containing 5-fluorouracil and triamcinolone with biphasic release\nprofile for hypertrophic scar therapy","volume":"6","author":"Yang","year":"2021","journal-title":"Bioact.\nMater."},{"issue":"3","key":"2026081812071277600_cit5","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1667\/rade-23-00229.1","article-title":"Relative Biological\nEffectiveness of Carbon Ion Beams for Induction of Medulloblastoma\nwith Radiation-specific Chromosome 13 Deletion in Ptch1\u00b1 Mice","volume":"202","author":"Tsuruoka","year":"2024","journal-title":"Radiat. 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Oral Maxillofac Surg."},{"key":"2026081812071277600_cit9","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/765832","article-title":"Resveratrol oligomers\nfor the prevention and treatment of cancers","volume":"2014","author":"Xue","year":"2014","journal-title":"Oxid Med. Cell Longev."},{"issue":"2","key":"2026081812071277600_cit10","doi-asserted-by":"publisher","first-page":"142","DOI":"10.2174\/18755666MTA2pODE0z","article-title":"Resveratrol Induces\nApoptosis and Attenuates Proliferation of MCF-7 Cells in Combination\nwith Radiation and Hyperthermia","volume":"21","author":"Amini","year":"2021","journal-title":"Curr. Mol.\nMed."},{"issue":"29","key":"2026081812071277600_cit11","doi-asserted-by":"publisher","first-page":"2634","DOI":"10.2174\/1568026621666211105093658","article-title":"Resveratrol and Colorectal\nCancer: A Molecular Approach to Clinical Research","volume":"21","author":"Vernousfaderani","year":"2021","journal-title":"Curr. Top Med. 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Med. Rep."},{"issue":"1","key":"2026081812071277600_cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11320-y","article-title":"Physical and Pharmacokinetic\nCharacterizations of trans-Resveratrol (t-Rev) Encapsulated with Self-Assembling\nLecithin-based Mixed Polymeric Micelles (saLMPMs)","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"key":"2026081812071277600_cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104265","article-title":"Pterostilbene:Mechanisms\nof its action as oncostatic agent in cell models and in vivo studies","volume":"145","author":"Ma","year":"2019","journal-title":"Pharmacol. 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Macromol."},{"key":"2026081812071277600_cit25","doi-asserted-by":"publisher","first-page":"192","DOI":"10.3389\/fvets.2019.00192","article-title":"Hyaluronic Acid:Molecular\nMechanisms and Therapeutic Trajectory","volume":"l6","author":"Gupta","year":"2019","journal-title":"Front.\nVet. Sci."},{"issue":"2","key":"2026081812071277600_cit26","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1097\/PRS.0000000000005274","article-title":"A Novel\nModel for Cutaneous\nWound Healing and Scarring in the Rat","volume":"143","author":"Zhou","year":"2019","journal-title":"Plast\nReconstr Surg."},{"issue":"2","key":"2026081812071277600_cit27","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1097\/00004630-199803000-00019","article-title":"Reliability\nof photographic\nanalysis in determining change in scar appearance","volume":"19","author":"Crowe","year":"1998","journal-title":"J. Burn Care Rehabil."},{"issue":"1","key":"2026081812071277600_cit28","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.burns.2011.09.021","article-title":"A systematic review\nof the quality of burn scar rating scales for clinical and research\nuse","volume":"38","author":"Tyack","year":"2012","journal-title":"Burns."},{"issue":"15","key":"2026081812071277600_cit29","doi-asserted-by":"publisher","first-page":"17936","DOI":"10.1021\/acsami.9b21528","article-title":"Injectable and in situ-formable thiolated chitosan-coated\nliposomal hydrogels as curcumin carriers for prevention of in vivo\nbreast cancer recurrence","volume":"12","author":"Li","year":"2020","journal-title":"ACS Appl. Mater. 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