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When cellular redox homeostasis is chronically affected by ROS overproduction or insufficient antioxidant activity (i.e., oxidative stress), different pathologies develop as a result of inflammation. Bioactive antioxidant compounds have been widely used to counter oxidative stress. However, the analytical methods available to explore their ROS scavenging capacity do not allow a comparison between different ROS species for a compound. In this work, we present an optical approach to evaluate the ROS-specific neutralization capacity of bioactive compounds as a function of the pH value, carrier system, and synergy among several compounds. We analyzed the profile of 11 natural antioxidants against four different ROS of physiological relevance: 1O2, OH\u2013, H2O2\u00b7, and O2\u2022\u2212. Our results show a specific antioxidant signature for each compound. We also found that liposomes have a great influence on the ROS neutralization properties of the compound together with the structural state driven by pH. Moreover, we observed both positive and negative synergistic effects for some dyads. The relevance and versatility of this method may lead to significant improvements in the drug delivery and formulation of antioxidants in the cosmetic and food industries.<\/jats:p>","DOI":"10.1021\/acsomega.5c01738","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T19:35:54Z","timestamp":1749843354000},"page":"26857-26870","source":"Crossref","is-referenced-by-count":4,"title":["ROS-Specific Neutralization\nof Bioactive Compounds:\nAn Optical Approach"],"prefix":"10.1021","volume":"10","author":[{"given":"Toma\u0301s\nJ.","family":"Buenfil-Chi","sequence":"first","affiliation":[{"name":"CINVESTAV - Monterrey, Parque PIIT , Autopista al Aeropuerto, km. 9.5 , , ,","place":["Apodaca, Nuevo Leo\u0301n, Me\u0301xico, 66600"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilda","family":"Mercado-Uribe","sequence":"additional","affiliation":[{"name":"CINVESTAV - Monterrey, Parque PIIT , Autopista al Aeropuerto, km. 9.5 , , ,","place":["Apodaca, Nuevo Leo\u0301n, Me\u0301xico, 66600"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7803-9701","authenticated-orcid":true,"given":"Francisco J.","family":"Sierra-Valdez","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey , , Ave. Eugenio Garza Sada 2501 Sur, Col: Tecnologico , , ,","place":["Monterrey, Nuevo Leo\u0301n, Mexico, 64700"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,6,13]]},"reference":[{"key":"2026081811265411900_cit1","doi-asserted-by":"publisher","first-page":"4642","DOI":"10.3390\/ijms22094642","article-title":"The chemistry\nof reactive oxygen species (ROS) revisited: Outlining their role in\nbiological macromolecules (DNA, lipids and proteins) and induced pathologies","volume":"22","author":"Juan","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"2026081811265411900_cit2","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1186\/cc3992","article-title":"Reactive oxygen\nspecies: Toxic molecules or spark of life","volume":"10","author":"Magder","year":"2006","journal-title":"Crit\nCare."},{"key":"2026081811265411900_cit3","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1104\/pp.106.077073","article-title":"Reactive species\nand antioxidants. Redox biology is a fundamental theme of aerobic\nlife","volume":"141","author":"Halliwell","year":"2006","journal-title":"Plant Physiol."},{"key":"2026081811265411900_cit4","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","article-title":"Reactive oxygen\nspecies, toxicity,\noxidative stress, and antioxidants: Chronic diseases and aging","volume":"97","author":"Jomova","year":"2023","journal-title":"Arch. Toxicol."},{"key":"2026081811265411900_cit5","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0000000000000373","article-title":"Novel insights in pathophysiology\nof antiblastic drugs-induced\ncardiotoxicity and cardioprotection","volume":"17","author":"Deidda","year":"2016","journal-title":"J. Cardiovasc.\nMed."},{"key":"2026081811265411900_cit6","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/978-1-4419-7347-4","volume-title":"Bio-farms\nfor nutraceuticals: Functional\nfood and safety control by biosensors","author":"Giardi","year":"2010"},{"key":"2026081811265411900_cit7","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/s41573-021-00233-1","article-title":"Targeting oxidative\nstress in disease: Promise and limitations of\nantioxidant therapy","volume":"20","author":"Forman","year":"2021","journal-title":"Nat. Rev. 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Pineal Res."},{"key":"2026081811265411900_cit49","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.jfca.2012.07.001","article-title":"Comparative\nevaluation of the antioxidant activity of melatonin and related indoles","volume":"28","author":"Rodriguez-Naranjo","year":"2012","journal-title":"J. Food Compos. Anal."},{"key":"2026081811265411900_cit50","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.jff.2017.10.047","article-title":"Antioxidant and anti-inflammatory activities of quercetin\nand its derivatives","volume":"40","author":"Lesjak","year":"2018","journal-title":"J. Funct. Foods"},{"key":"2026081811265411900_cit51","doi-asserted-by":"publisher","first-page":"4234","DOI":"10.1021\/jp0451389","article-title":"Kinetic study\nof the quenching reaction\nof singlet oxygen by flavonoids in ethanol solution","volume":"109","author":"Nagai","year":"2005","journal-title":"J. Phys. Chem. 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Photobiol."},{"key":"2026081811265411900_cit58","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1111\/1541-4337.12298","article-title":"Plant polyphenols as antioxidant\nand antibacterial\nagents for shelf-life extension of meat and meat products: Classification,\nstructures, sources, and action mechanisms","volume":"16","author":"Papuc","year":"2017","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"2026081811265411900_cit59","doi-asserted-by":"publisher","first-page":"100077","DOI":"10.1016\/j.arres.2023.100077","article-title":"Stability of aqueous\nsolutions of ascorbate for basic\nresearch and for intravenous administration","volume":"9","author":"Wagner","year":"2023","journal-title":"Adv. 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