{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T10:10:07Z","timestamp":1748945407813,"version":"3.41.0"},"reference-count":57,"publisher":"American Chemical Society (ACS)","issue":"21","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007137","name":"Helse Nord RHF","doi-asserted-by":"publisher","award":["HNF1426-18"],"award-info":[{"award-number":["HNF1426-18"]}],"id":[{"id":"10.13039\/501100007137","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007465","name":"Universitetet i Troms?","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007465","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2025,6,3]]},"DOI":"10.1021\/acsomega.5c02102","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T19:45:18Z","timestamp":1747424718000},"page":"22005-22017","source":"Crossref","is-referenced-by-count":0,"title":["Identification of Orthosteric GABA<sub>B<\/sub> Receptor Ligands by Virtual Screening and <i>In Vitro<\/i> Validation"],"prefix":"10.1021","volume":"10","author":[{"given":"Linn S. M.","family":"Evenseth","sequence":"first","affiliation":[{"name":"Pharmacology and Toxicology, Department of Medical Biology, Faculty of Health Sciences","place":["Troms\u00f8, Norway"]},{"name":"UiT The Arctic University of Norway","place":["Troms\u00f8, Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clizia","family":"Russotto","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology, Department of Medical Biology, Faculty of Health Sciences","place":["Troms\u00f8, Norway"]},{"name":"UiT The Arctic University of Norway","place":["Troms\u00f8, Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imin","family":"Wushur","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology, Department of Medical Biology, Faculty of Health Sciences","place":["Troms\u00f8, Norway"]},{"name":"UiT The Arctic University of Norway","place":["Troms\u00f8, Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawid","family":"Warszycki","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Maj Institute of Pharmacology","place":["Krak\u00f3w, Poland"]},{"name":"Polish Academy of Sciences","place":["Krak\u00f3w, Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel S.","family":"Moldes-Anaya","sequence":"additional","affiliation":[{"name":"Cyclotron and Radiochemistry Unit, Section for Radiopharmaceutical Production, The PET Imaging Center","place":["Troms\u00f8, Norway"]},{"name":"University Hospital of North Norway (UNN)","place":["Troms\u00f8, Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1417-6333","authenticated-orcid":true,"given":"Andrzej J.","family":"Bojarski","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Maj Institute of Pharmacology","place":["Krak\u00f3w, Poland"]},{"name":"Polish Academy of Sciences","place":["Krak\u00f3w, Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Gabrielsen","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology, Department of Medical Biology, Faculty of Health Sciences","place":["Troms\u00f8, Norway"]},{"name":"UiT The Arctic University of Norway","place":["Troms\u00f8, Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3290-3736","authenticated-orcid":true,"given":"Ingebrigt","family":"Sylte","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology, Department of Medical Biology, Faculty of Health Sciences","place":["Troms\u00f8, Norway"]},{"name":"UiT The Arctic University of Norway","place":["Troms\u00f8, Norway"]},{"name":"Center for Research and Education","place":["Troms\u00f8, Norway"]},{"name":"University Hospital of North Norway (UNN)","place":["Troms\u00f8, Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R112.386664"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abg3362"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2011.186"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3390\/membranes13030301"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-032112-135923"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00128"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/nature20566"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25133093"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/386239a0"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2004.10.013"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/nature12725"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3133"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10834-5"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1002\/0471250953.bi0506s15"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173889"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1124\/mol.60.5.881"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2020.09.023"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0350-5"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2469-4"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2452-0"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2408-4"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.70188"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3249"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00262-1"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000000880"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/syn.21973"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.01.007"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2005.41.11.904728"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(10)58014-1"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12506"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-199212000-00008"},{"key":"ref32\/cit32","first-page":"97","author":"Bittiger H.","year":"1996","journal-title":"Pharmacology"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-0348-8990-2_33"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24050935"},{"key":"ref35\/cit35","first-page":"127","volume":"8","author":"Froestl W.","year":"1996","journal-title":"Pharmacology"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/jm00017a016"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.5b00559"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21859"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-013-9644-8"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/jm0306430"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/jm051256o"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/j.1538-7305.1956.tb03809.x"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2021.108537"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2020.127443"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmgm.2010.05.008"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23168898"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-317-6_12"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-317-6_10"},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/978-3-031-67148-7_9","volume-title":"GABAB Receptor","volume":"36","author":"Evenseth L. S. M.","year":"2024","edition":"2"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/ct500189s"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.9b00751"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyy071"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1008"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(02)01658-1"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-016-0137-3"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.9b01025"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2020.110541"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c02102","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c02102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T09:31:26Z","timestamp":1748943086000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.5c02102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,16]]},"references-count":57,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2025,6,3]]}},"alternative-id":["10.1021\/acsomega.5c02102"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.5c02102","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"type":"print","value":"2470-1343"},{"type":"electronic","value":"2470-1343"}],"subject":[],"published":{"date-parts":[[2025,5,16]]}}}