{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:17:13Z","timestamp":1791685033157,"version":"4.3.4"},"reference-count":105,"publisher":"American Chemical Society (ACS)","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Merck Sharp and Dohme LLC"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"DOI":"10.1021\/acsomega.5c02571","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T05:35:47Z","timestamp":1763962547000},"source":"Crossref","is-referenced-by-count":3,"title":["Engineering Extended Release Profiles for Biologic Formulations via Chemical Cross-Linking of Poloxamer 407 Hydrogels"],"prefix":"10.1021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6144-003X","authenticated-orcid":true,"given":"Jungsoo","family":"Park","sequence":"first","affiliation":[{"name":"Discovery Pharmaceutical Sciences","place":["West Point, United States"]},{"name":"Merck & Co., Inc.","place":["West Point, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0655-9580","authenticated-orcid":true,"given":"Yu-Jiun","family":"Lin","sequence":"additional","affiliation":[{"name":"Materials and Biophysical Characterization","place":["Rahway, United States"]},{"name":"Merck & Co., Inc.","place":["Rahway, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1402-9934","authenticated-orcid":true,"given":"Kingshuk","family":"Dutta","sequence":"additional","affiliation":[{"name":"Discovery Pharmaceutical Sciences","place":["West Point, United States"]},{"name":"Merck & Co., Inc.","place":["West Point, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth","family":"Forster","sequence":"additional","affiliation":[{"name":"Discovery Pharmaceutical Sciences","place":["West Point, United States"]},{"name":"Merck & Co., Inc.","place":["West Point, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Okoh","sequence":"additional","affiliation":[{"name":"Discovery Pharmaceutical Sciences","place":["West Point, United States"]},{"name":"Merck & Co., Inc.","place":["West Point, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Tian","sequence":"additional","affiliation":[{"name":"Materials and Biophysical Characterization","place":["Rahway, United States"]},{"name":"Merck & Co., Inc.","place":["Rahway, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8981-7951","authenticated-orcid":true,"given":"Yingkai","family":"Liang","sequence":"additional","affiliation":[{"name":"Discovery Pharmaceutical Sciences","place":["West Point, United States"]},{"name":"Merck & Co., Inc.","place":["West Point, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,11,23]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2399"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4363"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-021-00698-w"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2007.07.011"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1039\/D1CB00067E"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.183"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/185117a0"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200501612"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c01177"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2016.71"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.6b01604"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.03.052"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2004.03.019"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2008.01.057"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.03.007"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.0c02009"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics10030159"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-006-9104-4"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.03.050"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120316"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1002\/jps.24693"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055925"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/la400268p"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.3390\/polym14173624"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(97)01648-9"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(99)00119-2"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-012-0843-0"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.07.055"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1163\/156856207782246803"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.04.032"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-020-2763-8"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/biot.200700251"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2009.06.002"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3935(200207)203:10\/11<1466::AID-MACP1466>3.0.CO;2-P"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2003.12.015"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2009.04.026"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2010.07.004"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.7b00587"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2006.03.001"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2004.10.029"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/bm100137q"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.35545"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/bm049607o"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1177\/0022034518810213"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(58)90014-6"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32134"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2014.05.023"},{"issue":"4","key":"ref48\/cit48","first-page":"110","volume":"60","author":"Peppas N. A.","year":"1985","journal-title":"Pharm. Acta Helv."},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(02)00271-7"},{"key":"ref50\/cit50","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780198520597.001.0001","volume-title":"Polymer Physics","author":"Rubinstein M.","year":"2003"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2010.07.016"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1063\/1.1723791"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1039\/C5BM00256G"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(05)80083-X"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abo0502"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c01306"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.200900304"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.9b00598"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.4676"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1007\/s40268-023-00437-3"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1007\/s40259-016-0184-3"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-011-0538-y"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-021-03119-4"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1021\/ac100575n"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2004.12.033"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201100186"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200700958"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22083952"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-021-03103-y"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1080\/19768354.2021.1943709"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1080\/19420862.2016.1259046"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2022.12.027"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26113332"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.0c02677"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1480"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14757-4"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0737381100"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.06.061"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.20091"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.05.045"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1186\/1754-1611-9-1"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-013-1195-0"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-011-0460-3"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(98)00025-8"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34701"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000505"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.637209"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-022-00377-1"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.5.785"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.07.029"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abn5315"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.05.012"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abn8264"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-55904-z"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1021\/acspolymersau.1c00049"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.3390\/polym13020266"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707090104"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.1021\/ja8053805"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.4c00084"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.07.052"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120750"},{"key":"ref102\/cit102","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2024.122173"},{"key":"ref103\/cit103","doi-asserted-by":"publisher","DOI":"10.1039\/D2BM01113A"},{"key":"ref104\/cit104","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201500005"},{"key":"ref105\/cit105","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2014.10.001"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c02571","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c02571","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T11:15:49Z","timestamp":1765278949000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.5c02571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,23]]},"references-count":105,"alternative-id":["10.1021\/acsomega.5c02571"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.5c02571","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"value":"2470-1343","type":"print"},{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,23]]},"article-number":"acsomega.5c02571"}}