{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:02:49Z","timestamp":1787000569228,"version":"build-2736575974"},"reference-count":59,"publisher":"American Chemical Society (ACS)","license":[{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008968","name":"Istanbul Kalkinma Ajansi","doi-asserted-by":"publisher","award":["TR10\/21\/YEP\/0133"],"award-info":[{"award-number":["TR10\/21\/YEP\/0133"]}],"id":[{"id":"10.13039\/501100008968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015732","name":"Bah?esehir ?niversitesi","doi-asserted-by":"publisher","award":["BAP.2024.01.42 and BAP.2022.01-12"],"award-info":[{"award-number":["BAP.2024.01.42 and BAP.2022.01-12"]}],"id":[{"id":"10.13039\/501100015732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"DOI":"10.1021\/acsomega.5c03150","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:29:46Z","timestamp":1760970586000},"source":"Crossref","is-referenced-by-count":2,"title":["Targeting Ubiquitin-Specific Protease 7 (USP7): A Pharmacophore-Guided Drug Repurposing and Physics-Based Molecular Simulation Study"],"prefix":"10.1021","author":[{"given":"Duaa","family":"Kanan","sequence":"first","affiliation":[{"name":"Department of Internal Medicine","place":["Peoria, United States"]},{"name":"University of Illinois College of Medicine","place":["Peoria, United States"]},{"name":"Computational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine","place":["Istanbul, T\u00fcrkiye"]},{"name":"Bahcesehir University","place":["Istanbul, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Kanan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine","place":["Peoria, United States"]},{"name":"University of Illinois College of Medicine","place":["Peoria, United States"]},{"name":"Computational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine","place":["Istanbul, T\u00fcrkiye"]},{"name":"Bahcesehir University","place":["Istanbul, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berna","family":"Dogan","sequence":"additional","affiliation":[{"name":"Computational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine","place":["Istanbul, T\u00fcrkiye"]},{"name":"Bahcesehir University","place":["Istanbul, T\u00fcrkiye"]},{"name":"Department of Chemistry","place":["Istanbul, T\u00fcrkiye"]},{"name":"Istanbul Technical University","place":["Istanbul, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8256-6283","authenticated-orcid":true,"given":"Ismail","family":"Erol","sequence":"additional","affiliation":[{"name":"Computational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine","place":["Istanbul, T\u00fcrkiye"]},{"name":"Bahcesehir University","place":["Istanbul, T\u00fcrkiye"]},{"name":"Department of Analytical Chemistry, School of Pharmacy","place":["Istanbul, T\u00fcrkiye"]},{"name":"Bahcesehir University","place":["Istanbul, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serdar","family":"Durda\u011f\u0131","sequence":"additional","affiliation":[{"name":"Computational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine","place":["Istanbul, T\u00fcrkiye"]},{"name":"Bahcesehir University","place":["Istanbul, T\u00fcrkiye"]},{"name":"Molecular Therapy Lab, Department of Pharmaceutical Chemistry, School of Pharmacy","place":["Istanbul, T\u00fcrkiye"]},{"name":"Bahcesehir University","place":["Istanbul, T\u00fcrkiye"]},{"name":"Laboratory for Innovative Drugs (Lab4IND), Computational Drug Design Center (H\u0130TMER)","place":["\u0130stanbul, T\u00fcrkiye"]},{"name":"Bah\u00e7e\u015fehir University","place":["\u0130stanbul, T\u00fcrkiye"]},{"name":"Systems Biology Lab, Biruni University Scientific Research Center","place":["Istanbul, T\u00fcrkiye"]},{"name":"Biruni University","place":["Istanbul, T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00427"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00233"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.650165"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-020-1109-2"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03732-6"},{"key":"ref6\/cit6","first-page":"299","volume":"10","author":"Zheng N.","year":"2020","journal-title":"Am. J. Cancer Res."},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1172\/JCI120518"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-018-0012-y"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-2773-4"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16348"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/nature07290"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.2A1017-420RR"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-20-0184"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12030629"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.648491"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.08.007"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13071513"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2020.10.028"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.7b00512"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/nature24451"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2528"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2017.09.003"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202000675"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.168"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.07.013"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-012-9390-1"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.12793\/tcp.2019.27.2.59"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.3906\/biy-2005-112"},{"key":"ref29\/cit29","volume-title":"Schrodinger: Phase","author":"Schrodinger","year":"2015"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1063\/1.467468"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevA.31.1695"},{"key":"ref32\/cit32","volume-title":"Desmond Molecular Dynamics System","author":"D. E. Shaw Research","year":"2016"},{"key":"ref33\/cit33","volume-title":"Schrodinger: Prime","author":"Schrodinger","year":"2016"},{"key":"ref34\/cit34","volume-title":"Schrodinger: Maestro-Desmond Interoperability Tools","author":"Schrodinger","year":"2016"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21144842"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003273"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1208446110"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/prot.23106"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/ct300418h"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/ci100050t"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/jm401411z"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/ci9803381"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmgm.2018.09.014"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11040582"},{"key":"ref45\/cit45","volume-title":"The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances 2011","author":"WHO Document Production Services","year":"2011"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.4c00570"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1039\/D4MD00495G"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48156-w"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.4c04456"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c10182"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2022.23.5.1803"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14225539"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abo0789"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.9b00367"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-82483-8"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20593"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-013-0791-2"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.737776"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.0c00154"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c03150","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c03150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T09:49:29Z","timestamp":1762249769000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.5c03150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,20]]},"references-count":59,"alternative-id":["10.1021\/acsomega.5c03150"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.5c03150","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.04.07.647568","asserted-by":"object"}]},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"value":"2470-1343","type":"print"},{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,20]]},"article-number":"acsomega.5c03150"}}