{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:17:03Z","timestamp":1785417423927,"version":"3.56.0"},"reference-count":74,"publisher":"American Chemical Society (ACS)","issue":"40","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2025,10,14]]},"DOI":"10.1021\/acsomega.5c04079","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T03:08:58Z","timestamp":1759201738000},"page":"46238-46247","source":"Crossref","is-referenced-by-count":2,"title":["GPR17 in Glioblastoma: Structure, Ligand Interactions, and Therapeutic Targeting"],"prefix":"10.1021","volume":"10","author":[{"given":"Ramalakshmi","family":"Satyanarayana","sequence":"first","affiliation":[{"name":"Faculty of Clinical Research","place":["Chennai, India"]},{"name":"Sri Ramachandra Institute of Higher Education and Research","place":["Chennai, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sree Somala","family":"Chaitanya","sequence":"additional","affiliation":[{"name":"B Aatral Biosciences Private Limited","place":["Bengaluru, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0505-3848","authenticated-orcid":true,"given":"Iswarya","family":"Suresh Kumar","sequence":"additional","affiliation":[{"name":"B Aatral Biosciences Private Limited","place":["Bengaluru, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Thiyagarajan","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, College of Medicine","place":["Al-Kharj, Saudi Arabia"]},{"name":"Prince Sattam Bin Abdulaziz University","place":["Al-Kharj, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sureka","family":"Chandrabose","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, College of Medicine","place":["Al-Kharj, Saudi Arabia"]},{"name":"Prince Sattam Bin Abdulaziz University","place":["Al-Kharj, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasim S.","family":"Abass","sequence":"additional","affiliation":[{"name":"Department of Physiology, Biochemistry, and Pharmacology, College of Veterinary Medicine","place":["Kirkuk, Iraq"]},{"name":"University of Kirkuk","place":["Kirkuk, Iraq"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5541-234X","authenticated-orcid":true,"given":"Saravanan","family":"Konda Mani","sequence":"additional","affiliation":[{"name":"B Aatral Biosciences Private Limited","place":["Bengaluru, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Thirunavukarasou","sequence":"additional","affiliation":[{"name":"Faculty of Clinical Research","place":["Chennai, India"]},{"name":"Sri Ramachandra Institute of Higher Education and Research","place":["Chennai, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4986-055X","authenticated-orcid":true,"given":"Meenakshisundaram","family":"Kandhavelu","sequence":"additional","affiliation":[{"name":"Molecular Signaling Group, Faculty of Medicine and Health Technology","place":["Tampere, Finland"]},{"name":"Tampere University","place":["Tampere, Finland"]},{"name":"BioMeditech and Tays Cancer Center","place":["Tampere, Finland"]},{"name":"Tampere University Hospital","place":["Tampere, Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601341"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.105668"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.02.060"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.683953"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003579"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.10.011"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2024.111959"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094574"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.3390\/cells11152369"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108335"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2024.176755"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/5584_2017_92","volume-title":"Protein Reviews","volume":"19","author":"Fumagalli M.","year":"2017"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1841029"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01427-2"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.3390\/cells10081975"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13153773"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2016.00103"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2021.1977707"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02958-9"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01946"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04738-6"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.31557\/apjcb.2023.8.1.75-89"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14020443"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24087047"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00021.2020"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1186\/s43556-023-00156-w"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1178"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2020.07.003"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-2632"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21051852"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.159"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22452-0"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23807"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00435-w"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/nature14287"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2023.2299945"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201600453"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1349097"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-263"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00277"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.08.088"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.30388"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2410"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1394516"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/glia.24356"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-008-9127-x"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.3390\/ph16101501"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.629618"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2024.02.023"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905364106"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00633.x"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa971"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv951"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2022.07.009"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28124691"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbae281"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.902048"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2004350"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.06.003"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01768"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15969"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2018.03.012"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.REV119.005601"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.135"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2014.02.016"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-023-01144-4"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.178715"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23015"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.3390\/cimb44050149"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1002\/9781119564782.ch8"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13335"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.20517\/cdr.2020.79"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7849890"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106315"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c04079","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c04079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T09:10:41Z","timestamp":1760433041000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.5c04079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,29]]},"references-count":74,"journal-issue":{"issue":"40","published-print":{"date-parts":[[2025,10,14]]}},"alternative-id":["10.1021\/acsomega.5c04079"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.5c04079","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"value":"2470-1343","type":"print"},{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,29]]}}}